DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lama4

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_002936983.2 Gene:lama4 / 100489161 XenbaseID:XB-GENE-1004770 Length:1913 Species:Xenopus tropicalis


Alignment Length:2769 Identity:557/2769 - (20%)
Similarity:891/2769 - (32%) Gaps:1070/2769 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   767 FLSVLVSL-------DAVLIRAAFHTD-QGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTG 823
            |:.:|:||       ...:..:|||.| :|.||:.           .|:...|::....||....
 Frog     9 FICMLMSLWRYLCVCSGSMEGSAFHLDSEGSTSIP-----------SGQDMVQLQHVYIPARLVP 62

  Fly   824 LSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYY 888
             ..:.|..||.        :.:..:|:||.|||::..|...||.|.||..||.|.:|:||..||.
 Frog    63 -PAQRCHMGFY--------YSVSGECLPCNCNGNAQKCLDGSGECLDCQRNTTGKQCDRCPPGYL 118

  Fly   889 GNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHC 953
            ||.::|.|..|..|.|||....|||:.:|.:||.:...:                |.:.|.|.:|
 Frog   119 GNVVRGVPKSCLPCPCPLPFSPNNFAIACGVKSGSVRCI----------------CKDNYAGPNC 167

  Fly   954 QVCDDGYFGNPRQPGSSCQRCDCAGG--------PCNVTTGECITCRGNTEGWHCERCKLGYWGD 1010
            :.|..||:|||...||:|::|||:|.        .||..||:|..|..||.|::||||.|||:||
 Frog   168 ERCAPGYYGNPLLKGSTCKKCDCSGNSDPNLIFEDCNELTGQCNNCMRNTTGFNCERCALGYYGD 232

  Fly  1011 PAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQ 1075
            ..|                               .:.|.||         ||..|.        .
 Frog   233 ARV-------------------------------AKNCKEC---------RCSKCG--------T 249

  Fly  1076 DRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPN 1140
            :.|:..||.|.||.||.|..|..|:.||:|..                                 
 Frog   250 ETCNDITGTCQCKPGVTGVFCDHCEAGYYGYT--------------------------------- 281

  Fly  1141 SESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHG 1205
              |.:.|::|.||. .||.::||..|.||.|.....|.:|::|:||:||                
 Frog   282 --SCLGCQKCMCSP-ASLDNNCDPETRQCNCKPGAGGLKCERCKPGYWN---------------- 327

  Fly  1206 SRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFT 1270
                                           :|.|                              
 Frog   328 -------------------------------YGPS------------------------------ 331

  Fly  1271 RGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYP 1335
                               ||::|:|            |||.|.                     
 Frog   332 -------------------GCQKCDC------------GDGPCN--------------------- 344

  Fly  1336 ECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGR 1400
                                                                           .:
 Frog   345 ---------------------------------------------------------------NK 346

  Fly  1401 SGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSL 1465
            :|||...|                    |.|..|||           .||..:......::||.:
 Frog   347 TGECLLED--------------------PESPSSSD-----------CSFDCDKCIWDLIDDLRI 380

  Fly  1466 V------PKSTG-NVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNIL 1523
            .      .|:|. |:|.|.                                   .|||.|.    
 Frog   381 AALLGDETKTTALNISTGV-----------------------------------AAHKHLN---- 406

  Fly  1524 GQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHI 1588
                    :.:|.|                            :|.|....|:|.     |:|   
 Frog   407 --------YINSTL----------------------------FHLTEMLEDKNN-----QSI--- 427

  Fly  1589 FIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTT 1653
                     |.::::.|....... ::...|.:|.                              
 Frog   428 ---------FTDLMIDNAESKVEA-LQTKVNELAD------------------------------ 452

  Fly  1654 IVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTG---GDHCHQCAEGFYGDPNSPHGC 1715
                                                :||..   |...|:               
 Frog   453 ------------------------------------KGNLAEMKGSRFHK--------------- 466

  Fly  1716 QACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGI 1780
                  ||.....|.                      :..||...|              ..|||
 Frog   467 ------ETMETMKRA----------------------KMTAGQVND--------------IEDGI 489

  Fly  1781 QTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHN 1845
            |                                                   ||:|         
 Frog   490 Q---------------------------------------------------ELLG--------- 494

  Fly  1846 MDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQ-DYDSADILKLEAHAENLKFQSRKAVA 1909
                       ||..|||                  || |..:||.:|....||.:         
 Frog   495 -----------KLEYYES------------------LQGDLSAADRVKSVKQAEQM--------- 521

  Fly  1910 TIGKREFAIKSMRE-DAVTQ--------QHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQA 1965
                    :|.|.| |..||        ::...||| |||.....:....:|.    ||..|:: 
 Frog   522 --------LKEMEELDFSTQRIALEEEEEYVEELLR-EILDEWQQVQNNTRSL----LPNVLEK- 572

  Fly  1966 RFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQT--NHRVVDMR 2028
                  |.|||                        |...|....||....|:|||  .::....:
 Frog   573 ------IAEHD------------------------DELADLYEALEEARHDINQTREKNKANIAK 607

  Fly  2029 LQVDRVQEVE--NEAEDVLEHVRNLSIRVGESH---QELDELNQRISDH---LDPGYL---EQGE 2082
            |.:..:|.|:  .|.|:|.|.:...:|.:..:|   .::.::.:.:|.|   :|..|.   |:.|
 Frog   608 LHMSNIQTVKLTKEVENVSETLTQANITLNGTHMLISDISDITKNMSGHHAEVDGAYTGLKERLE 672

  Fly  2083 GLLR-------------LTVQRQIM-LNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEK 2133
            .|.|             ||:||:.. |...|..:|                              
 Frog   673 NLSRNVENIVEEAVAHSLTLQREASGLTSDLKGID------------------------------ 707

  Fly  2134 HASHLLARSNEYARKFQPTRNGARIAMLASSAHS---NITEAINDARLASILAKERVYEAQRTLY 2195
                    :|.:.:|          |:.||:.|.   |:.||.|:....::...|||.:|     
 Frog   708 --------ANGFVQK----------AIDASNVHESIVNMIEAANETSFIALSTAERVIDA----- 749

  Fly  2196 PSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISG 2260
             :||  |..:.|:.:..|                  :||..|.::::|...:..|.|     ||.
 Frog   750 -TDG--MDNQIKYQMTES------------------EKLLVQAKELKGASDSSKDLG-----ISE 788

  Fly  2261 QLQGLSDGSARRQA-KDSLEMA-----DRTGEQMRAELQKAK-DMQKSIQNMRNSFSNLEPDWEI 2318
            ..|.::..:.|:.| .|.:|.|     ....|..|..|:|:| |.:::: |:....|.:......
 Frog   789 TKQHVNSATLRKDALSDKIENAISQIEVHEDENTRKRLEKSKLDAEEAL-NITAIISKVTDPMSK 852

  Fly  2319 KLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV--------------W-NNSMAQQLQQ 2368
            ...:..||:|.|..:....|   ..:....|..:.:.||              | .|:::..:.:
 Frog   853 NAKIWSENLSNTDFDASAYN---KVVNSAGEAVRNLTEVVPLLLNKLRTVDYKWPTNNISSSILR 914

  Fly  2369 LRDQIAKARHAAEAIDVSLESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHL---- 2429
            :|:.||:.|..|..:.||:...|...:      ...|.| |...::...|..|..:|:.|.    
 Frog   915 IRELIAQTRSVASKVQVSMRFGGKSAV------DVNLKT-NAADLNAFSSISLYLNPIAHQEKPH 972

  Fly  2430 ---------ASSEGRHITLELYKRRVRLVWNLGGTTATVTHPMVVHTRDPKYDDAW--YHVEANR 2483
                     .:|...::.|.:....:..|:|||  :..|..|:     |.|..::|  |.     
 Frog   973 DKFIMYFGNKNSTSDYMGLAIKSNNLVYVYNLG--SGDVEIPL-----DSKPVNSWPGYF----- 1025

  Fly  2484 TLNLGSLV-VRRMNNYGE--LTPPNPVIITGSTDTEHTRFYQ-----SRSDRISL---------- 2530
                 ||: :.|:..:|:  ||.|:|      :.|...:|.:     .|...:.|          
 Frog  1026 -----SLIKIERLGRHGKVLLTVPSP------SSTAEEKFIKKGEATGRDSVLDLDPSSMVFYVG 1079

  Fly  2531 ---GGF---ASKDLQFTPGLNVVVHQVEVDNKPLGLWNF-------VTSEGSCGGSMVGAKESSA 2582
               .||   ||.||   ||....:....|::..:.|:||       ..:...|..:.:...:|.|
 Frog  1080 GVPSGFQLPASLDL---PGFVGCLELSTVNDDVVSLYNFKNIYNLNTATAPPCARNKLAFTQSRA 1141

  Fly  2583 SSTARHFNGLGYAQL--MKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGR 2645
            :|  ..|:|.|||.:  |:.|.|.|:...|.:::  ||..:|||:||.|:  ..:..|:.|..|.
 Frog  1142 AS--YFFDGTGYAVIRNMERRGRFTQVTRFDIEV--RTPVDNALIFLMVN--GTKFFSMELQDGY 1200

  Fly  2646 IMFRIDYG---DESKLEINTTKKYNVGQWIKIEAAR--EFSAKRSTENGMLRVNNDRPISGAPTL 2705
            :....|:|   ....|| ::.||:.|..      ||  |.|........|:.|.:.|.:...   
 Frog  1201 LRLHYDFGFAKGPVLLE-DSAKKFQVND------ARYHEISVIYHNSKKMILVVDRRHVKSV--- 1255

  Fly  2706 PVNIHLLPDLSKTV-----YYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQVNGETYDPLESSSY 2765
                    |..||.     .|:||.|...........|||..|.||:|..|...:.::.||....
 Frog  1256 --------DNEKTSIPFSDIYIGGAPSLVLQSVKSHLGADIAFKGCIKGFQFQKKDFNLLEEPDT 1312

  Fly  2766 YGVEPSCKN---MITKAGFSGNGYLELPSQSLRKRSN--TALVFRTLQPDCLLLLAAYPPEILGD 2825
            .|:...|..   |..:|.|:|..:: ..||.|....:  ....|:||||..|||..:        
 Frog  1313 LGISYGCPEESLMSRRAYFNGQSFI-ASSQKLAPFDSFEGGFSFKTLQPSGLLLYHS-------- 1368

  Fly  2826 YDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQ 2890
             :..|:   ||:|:..|.:.:.:..    ||:.|.:.:.:||:.|.|....:..:.:|:||:...
 Frog  1369 -EGADV---FSVSMDKGSVVLRIKD----IKVQSKNRKYSDGQSHFVVASVSPTRYQLLVDETDA 1425

  Fly  2891 EIRNLNGNPTVVSLPRDAGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFN--NRTINFNDALT 2953
            .::: ...|...||.  |...|.||       ||:..:..|..|.|.:..|.  :|.:...|...
 Frog  1426 SVQD-RQKPGASSLV--ARTFYFGG-------TPVGISQANFTGCISNAYFTRVDRDVEVEDFQK 1480

  Fly  2954 FA-NVQ---------------IGRNGPLMGSLKGGL-----YDVLLKTEPMIGKSFTASPEGCKR 2997
            :. .||               ..:||......||.|     .|..|::....|...|........
 Frog  1481 YTEKVQSSLYGCPVESPPVALFQKNGKNSSKDKGKLRKSVGMDKTLESHAAFGSKETEEDSEEVT 1545

  Fly  2998 IGSYSYEPNAFKFGDDIYSYSQLKLPERHF------WQRNFHLSFDFRSFYPNGMLYLSPGSKEK 3056
            :.|.|..|.|.:   ..:.|..:....:.|      :.....|....::...|||::..  |.::
 Frog  1546 LCSLSSRPKAAR---QAHLYGGIANSRQEFNHIPNGFNEKSELFVRLKTHSSNGMIFYV--SDKE 1605

  Fly  3057 PKHYVALVLKDGQLVLVV-RGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTSA 3120
            ..:::.|.|..|:|..:. .|:::..::...|.|||.||.|.......|..:.:...|..:.:.:
 Frog  1606 EDNFMTLFLSHGRLTFMFNNGQQKLRIKSQEKYNDGLWHSVLCIREKNKGRLIINGLRVLEDSIS 1670

  Fly  3121 QMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVR-LEPFKGCLRRVSINNNTQDLARPGKHSNVGQ 3184
            ...:...:.|.  ..:||:  :|.:...::.:. ...|.|||..:.:|...  |..|.:..:|..
 Frog  1671 AAAVTWTVDAP--FYLGGV--APGRAIKNVQINSAYSFNGCLSNLQLNGRA--LTSPSQTFSVTP 1729

  Fly  3185 CFP-TVERGSYFPGD-AYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNG 3247
            ||. .:|.|:|...: .|.|...:|:.|...:...|.|....||:|:.:.:.|| ..|:|.:..|
 Frog  1730 CFEGPMESGTYISSEGGYVILDDSFSTGLTFEFALEVRPRNNSGVLIHIQNVNG-EYLNLHMKQG 1793

  Fly  3248 NIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQGNAGKV 3312
            .:|.....||   ....:.:..|.::||.:||.|:.:.||..:.|.:|.  .:..|....|...:
 Frog  1794 QVIVKVKNGN---REFSTRVIPKQSICDGQWHRIAVIRDGNVVQLDVDS--EINHVVGPINTKVL 1853

  Fly  3313 QTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNER 3351
            ..:.|:::||:|.|....:|.:|.:|.||||:..| :||
 Frog  1854 DLKEPVFVGGVPGSLLGPTLTTRNSFTGCIRNFVI-DER 1891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481 11/38 (29%)
EGF_Lam 851..900 CDD:238012 23/48 (48%)
Laminin_EGF <943..971 CDD:278482 12/27 (44%)
VSP 953..1414 CDD:146106 87/468 (19%)
Laminin_EGF 974..1018 CDD:278482 23/51 (45%)
EGF_Lam 1017..1065 CDD:238012 5/47 (11%)
Laminin_EGF 1065..>1105 CDD:278482 14/39 (36%)
EGF_Lam 1150..1197 CDD:238012 18/46 (39%)
Laminin_EGF 1199..1247 CDD:278482 2/47 (4%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 6/47 (13%)
Laminin_EGF 1340..1392 CDD:278482 0/51 (0%)
Laminin_B 1486..1611 CDD:278481 14/124 (11%)
EGF_Lam 1669..1716 CDD:238012 4/49 (8%)
Laminin_EGF 1718..1767 CDD:278482 6/48 (13%)
EGF_Lam 1772..1819 CDD:238012 4/46 (9%)
CrfC <1933..2267 CDD:223771 74/363 (20%)
Laminin_II 2277..2400 CDD:283628 28/143 (20%)
LamG 2399..>2492 CDD:304605 21/108 (19%)
Laminin_G_2 2616..2755 CDD:280389 40/148 (27%)
Laminin_G_2 2804..2944 CDD:280389 36/141 (26%)
Laminin_G_2 3038..3169 CDD:280389 27/132 (20%)
LamG 3192..3347 CDD:238058 43/155 (28%)
lama4XP_002936983.2 EGF_Lam 81..120 CDD:238012 19/38 (50%)
EGF_Lam 131..186 CDD:238012 22/70 (31%)
EGF_Lam 188..240 CDD:238012 23/82 (28%)
EGF_Lam 242..286 CDD:214543 19/95 (20%)
EGF_Lam 289..333 CDD:214543 20/140 (14%)
Laminin_I 393..649 CDD:310534 86/613 (14%)
SCP-1 <519..>837 CDD:114219 92/449 (20%)
Laminin_II 829..958 CDD:368703 25/139 (18%)
LamG 975..1106 CDD:214598 32/156 (21%)
LamG 1143..1299 CDD:238058 50/179 (28%)
LamG 1329..1466 CDD:238058 41/163 (25%)
LamG 1582..1714 CDD:238058 27/137 (20%)
LamG 1743..1889 CDD:238058 42/152 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10734
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.