DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamb2

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_004914156.1 Gene:lamb2 / 100485566 XenbaseID:XB-GENE-5935962 Length:1793 Species:Xenopus tropicalis


Alignment Length:2339 Identity:508/2339 - (21%)
Similarity:809/2339 - (34%) Gaps:821/2339 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 GGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGICNAHS---------SDRAK 201
            |..||...: :|.|| ::...:|||...|:.||   .....|.|.:|::..         |.|  
 Frog    33 GSCYPATGDLLVGRADKLKATSTCGLRRAQPYCIVSHLQDEKKCFVCDSRKPYNPLYNPISHR-- 95

  Fly   202 QRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPA 266
               |:::|::.:...     ::.||||   :.|  ...|||.|||:..|. |:..:.:..:.|||
 Frog    96 ---IENVITTFAPHR-----KKAWWQS---ENG--VSAVTIQLDLEAEFH-FTHLIMTFKTFRPA 146

  Fly   267 SWILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGPLENG- 328
            :.::|:|.| |..::.::|||   .||...: |:|    :...:...|:||.:::|...|...| 
 Frog   147 AMLVERSADFGRTWQAYRYFG---HDCASSFPNVS----RSALRKVDEVICESRYSDIEPSTEGE 204

  Fly   329 VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQ 393
            |::..|....|......|.:...:....:||....:|:..  ||.||..::   :::..:|:|.:
 Frog   205 VIYRVLDPAIPIRDPYGPNIQNLLKITNLRINFTKLHTLG--DNLLDSRVE---IKEKYYYALYE 264

  Fly   394 LKVSARLDCNGHANR----SHESPDDPLM---QCICQHNTCGAQCEQCCPLFQDRPYQMG----- 446
            |.|.....|.|||:.    ...|.|...|   :|:|:|||.|..||||...|.|.|::..     
 Frog   265 LVVRGNCFCYGHASECAPIQGVSRDVEGMVHGRCVCKHNTKGLNCEQCDSSFNDLPWRPAEGRST 329

  Fly   447 GECEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP-- 502
            ..|:.|.|..|:..|.:|..       :..|:|..|.:||.|..||.|:..||::....|.|.  
 Frog   330 NACKKCNCNNHSRKCHFDMAVYLSTGNVSGGVCDDCVHNTMGRNCELCKPFFYKDPSKDLRDSAV 394

  Fly   503 CLPCSCNPARSTGG--CQS--------DGGSCNCLEGFQGKNCEECAPGYYG------DDCKRCE 551
            |..|.|:|..|..|  |.|        ..|.|.|.:..:|..|:.|..|::|      ..|:||:
 Frog   395 CKACDCDPDGSLDGGLCDSLDNPALGLIAGQCRCKDYVEGPRCDRCKTGFFGLSTNNFQGCQRCQ 459

  Fly   552 CDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCS-GVSQTCHSA 612
            ||.||::.....|   ||.|.||..|.|.||::|.|.::.|| .:..||.||.|. |.:...|.|
 Frog   460 CDPRGTISDGAQCDPISGDCFCKRFVTGRTCNQCLPEFWALS-HDLHGCRSCDCDIGGAWDNHCA 523

  Fly   613 KLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYGS 677
                           |:..:.:..|..|..:.|                |...||....|..|..
 Frog   524 ---------------TETGQCRCRSHMVGRQCN----------------QVKSGYYRIHLDHYTY 557

  Fly   678 RLQLVL---SWDVIRGDR-SGKPT--TGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGW- 735
            ..:..|   ...|:..:| .|:|.  |||...||.:.|:               |...::.:.: 
 Frog   558 EAESALHRQGCSVLERERLIGRPATWTGPGFALVPEGGI---------------LEFQISNIPYS 607

  Fly   736 --YHV--------PPTVVDIKTRLRR-----------------------TEGGDYH--------- 758
              |.|        |.|...:|..:.|                       ...|..|         
 Frog   608 MEYDVIIRYEPQLPATWEQVKISVIRPGPIPTSSPCGNTIPADDLMVASLPPGTRHVVLPQPVCL 672

  Fly   759 --GESVT----------RSQFLSVLVSLDAVLIRAAFH-----------TDQGETSLERAVIYSG 800
              |.|.|          |.:..|..:.:|::::...:.           :.|.:.:.||...:|.
 Frog   673 ERGVSYTIRLEFSRYSLREKIPSANILIDSLVLVPRYSSMEMFIAGDPASIQRKETFERYRCHSN 737

  Fly   801 GVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGH---SNSCD 862
            ...:...|:::|             |.|.......|        |....:||.|:..   |:.||
 Frog   738 SGNVIKSSTTEV-------------CSGLITSMSAI--------IHEGALPCSCDPQGSLSSECD 781

  Fly   863 LQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDL 927
            ...|.| .|..|..|.||:||..|.:|    ..|..||.|.|.:...::||   |..::      
 Frog   782 PNGGQC-QCKANVIGQRCDRCAPGTHG----FGPTGCKACECNMEGSTHNF---CDQRT------ 832

  Fly   928 NPQFELIEHAEYICTQCP--EGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG--GPCNVTTGEC 988
                          .|||  .|..|..|..|..|::|.|     :|::|.|.|  ..|:..||.|
 Frog   833 --------------GQCPCRPGAFGSRCDRCQPGHWGFP-----NCRQCQCNGHSEECDQRTGAC 878

  Fly   989 ITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHTEGSESG-----LC--DSTDGQ--CLCK 1040
            :.||.::.|..||||..|::|:|.:|    |.||.| .||..||     .|  |....|  |.||
 Frog   879 LNCRDHSTGDRCERCTAGFYGNPILGSGDHCRPCPC-PEGPNSGRHYAASCHQDPRSRQVICNCK 942

  Fly  1041 PRYAG----------QKCDECDVGYANVEL----RCPSCNCD------PLGSLVQDRCDPHTGQC 1085
            ..|.|          .:|:||..|:.....    ||..|.|:      .:|.     ||..:|||
 Frog   943 QGYTGLVKRAMGLRRPRCEECSPGFFGNPFQTGGRCLLCQCNNNIDMTDIGG-----CDRRSGQC 1002

  Fly  1086 -HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEE 1149
             .||....|..|..|:.|::|           .|.|:|                        |.:
 Frog  1003 LKCKYNTEGRFCEHCRIGFYG-----------DASRRN------------------------CRK 1032

  Fly  1150 CHCSSVGSLSSD--------CDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGS 1206
            |.|:.:|:..|.        ||:.:|||.||.||.|:.||:|.|..|||.:|:||:.|.|||:.|
 Frog  1033 CTCNYLGTEPSQCPSREDCMCDRTSGQCLCLPNVRGQNCDRCSPHFWNLASGKGCQPCNCDPNHS 1097

  Fly  1207 RGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTR 1271
            ....||.:||:|.|:.|.||..|.:|.|.:                                   
 Frog  1098 FSLSCNEFTGKCQCRPGFGGLTCTDCQENY----------------------------------- 1127

  Fly  1272 GLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YP 1335
                       || ...:.||.|:||..|....||:...|.|.||.|.||.:||.||.|:.| :|
 Frog  1128 -----------WG-NPNIQCRACDCDRRGIKAPQCNRASGHCDCRAGVSGVRCDQCARGFSGQFP 1180

  Fly  1336 ECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGR 1400
            :|:                         ||..                             ||| 
 Frog  1181 DCQ-------------------------PCHQ-----------------------------CFG- 1190

  Fly  1401 SGECEQSDLSWGHI--------RMAESRNLSVQQIRPHSVPSSDYEYIV--------VVQMEGSS 1449
                     .|..|        :....|...:||.....|...::..|.        :|....::
 Frog  1191 ---------DWDRIVQDLATRTKSLVQRGKDIQQSGVAGVYQKNFREIEKKLAKAQGIVNARNAT 1246

  Fly  1450 FHREDAEIQRMNDL-SLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEG 1513
            .......::.|:|| :.:.:||..::                 |..|:.|:..            
 Frog  1247 AESVTKLMKIMDDLRNKINESTEALT-----------------QLEGELTAVQ------------ 1282

  Fly  1514 AHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTL 1578
                 :.|....:.|.:|...::             |||:|                 |.:|:..
 Frog  1283 -----DENFDANHDLAELERDAR-------------SLNMT-----------------AKERSHQ 1312

  Fly  1579 MAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPG 1643
            :..|:|..  |:.|:.       .:|..|..:....|.:.|...               :...|.
 Frog  1313 LDVLKNSN--FLGAYD-------SIQQSHAKSRQAEKQANNATT---------------NVPSPV 1353

  Fly  1644 RSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGD 1708
            ....|.|..|       :.||        ..:..|.:|:..                        
 Frog  1354 SDSARTREKT-------QQLI--------THKRDDFNRKNA------------------------ 1379

  Fly  1709 PNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPC 1773
                          .||   |..|....:...:.......::|     |..||         .||
 Frog  1380 --------------ANR---RALNDLAAKTDTLDMKKINEKVC-----GAPGD---------APC 1413

  Fly  1774 NCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNK 1838
            :..|.|  ..||..:.|:.:|    .||.|            ||.             :....|.
 Frog  1414 SESPCG--GAGCRDDEGKRHC----GGLNC------------NGA-------------VATADNA 1447

  Fly  1839 LRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQ-DYDSADILKLEAHAENLKF 1902
            |.|..|..:     ...:.|.|.|..::|.........:.|:|.| ..|.|:  :.:|..|    
 Frog  1448 LGRARHAEE-----ELQKALGEVEVLFQKVAEAKVKADRAKQRAQATLDRAN--ETKARVE---- 1501

  Fly  1903 QSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARF 1967
            ||.|.:..:.::   ||...........|:.::.|.:|.              |::|...||.:.
 Frog  1502 QSNKELRELIQQ---IKDFLNQEGADPDSIEMVASRVLD--------------LTIPATPKQIQR 1549

  Fly  1968 YLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESG----RLEMLWRDLNQTNHRVVD-- 2026
            ..:.|::..:.:..:                  ||..|::.    :.|.|..:..:..:|..:  
 Frog  1550 LAEEIKDRVKTLANV------------------DAILDQTAADVRKAEQLLHEAKRAKNRAENVK 1596

  Fly  2027 -----MRLQVDRVQEVENEAE--------DVLEHVRNL-SIRVGESHQELDELNQRISDHLD-PG 2076
                 ::..:|..:..:|.||        |:.:..|.| :|:...|..|    || ::|.:| .|
 Frog  1597 NTAESVKRALDDARRAQNAAEGAIQSANDDIKDTERKLTAIQTATSSAE----NQ-LNDAMDRVG 1656

  Fly  2077 YLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLAR 2141
            .|::                    |:||.::                         |.|::.|| 
 Frog  1657 NLDK--------------------QIDGLKM-------------------------KRANNSLA- 1675

  Fly  2142 SNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERA 2206
                                ||.|..:.|.|::.|..|..:.:.::.:..:|:     .::::|.
 Frog  1676 --------------------ASRAEESATAALDKANDAKKILEGQLADKYKTV-----QNVVDRK 1715

  Fly  2207 KHSLHRSK----QLQQEALKQMHKSNVLKDKLHR-QEQQVEGIKS--TIYDSGLRTNNISGQLQ 2263
            ..::..:|    |||.||.|.:..:   :|||.| |:.:||..|:  .:.|...|.|.:..:::
 Frog  1716 AKNIKEAKTKADQLQDEAKKLLENA---QDKLKRLQDLEVEYTKNEKLLQDKAKRLNGLEDKMK 1776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 66/261 (25%)
EGF_Lam 401..450 CDD:238012 20/60 (33%)
EGF_Lam 505..552 CDD:238012 18/62 (29%)
Laminin_EGF 550..597 CDD:395007 19/49 (39%)
Laminin_B 660..813 CDD:459652 36/224 (16%)
EGF_Lam 851..900 CDD:238012 18/51 (35%)
Laminin_EGF <943..971 CDD:395007 10/29 (34%)
Laminin_EGF 974..1018 CDD:395007 19/49 (39%)
EGF_Lam 1017..1065 CDD:238012 21/70 (30%)
Laminin_EGF 1065..>1105 CDD:395007 14/46 (30%)
EGF_Lam 1150..1197 CDD:238012 23/54 (43%)
Laminin_EGF 1199..1247 CDD:395007 17/47 (36%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 21/48 (44%)
Laminin_EGF 1340..1392 CDD:395007 2/51 (4%)
Laminin_B 1486..1626 CDD:459652 20/139 (14%)
EGF_Lam 1669..1716 CDD:238012 2/46 (4%)
Laminin_EGF 1718..1767 CDD:395007 8/48 (17%)
EGF_Lam 1772..1819 CDD:238012 13/46 (28%)
YhaN <1907..2141 CDD:443752 38/254 (15%)
SMC_prok_B <2123..>2390 CDD:274008 31/148 (21%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamb2XP_004914156.1 Laminin_N 35..269 CDD:459653 66/261 (25%)
EGF_Lam 271..323 CDD:238012 20/51 (39%)
Laminin_EGF 335..386 CDD:395007 16/50 (32%)
Laminin_EGF 398..455 CDD:395007 15/56 (27%)
EGF_Lam 457..508 CDD:238012 21/51 (41%)
EGF_Lam 509..549 CDD:238012 13/70 (19%)
EGF_Lam 768..813 CDD:214543 17/49 (35%)
Laminin_EGF 816..864 CDD:395007 17/75 (23%)
Laminin_EGF 862..909 CDD:395007 18/46 (39%)
EGF_Lam 911..976 CDD:238012 19/65 (29%)
EGF_Lam 981..1029 CDD:238012 17/63 (27%)
Laminin_EGF 1033..1088 CDD:395007 23/54 (43%)
Laminin_EGF 1090..1138 CDD:395007 21/94 (22%)
EGF_Lam 1138..1182 CDD:214543 20/43 (47%)
PTZ00121 <1228..1776 CDD:173412 140/861 (16%)
cc_LAMB2_C 1722..1793 CDD:411970 18/58 (31%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.