DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and lamb3

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_012826649.2 Gene:lamb3 / 100125073 XenbaseID:XB-GENE-983491 Length:1157 Species:Xenopus tropicalis


Alignment Length:1468 Identity:296/1468 - (20%)
Similarity:467/1468 - (31%) Gaps:626/1468 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   852 CPCNGHSNSCDLQSG-----NCGD--------CMHNTFGDRCERCQLGYYGNPLQ----GTPNDC 899
            |.|.||::.| :.||     :.||        |.|||.|:.||||...::..|.:    ..||:|
 Frog   246 CFCYGHADRC-MPSGALDRDHYGDIQVYDKCICQHNTVGENCERCADLFHDLPWRPADDNYPNEC 309

  Fly   900 KRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNP 964
            :||.|      ||.:..|......|                                        
 Frog   310 RRCNC------NNHADKCHFDPAVY---------------------------------------- 328

  Fly   965 RQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGL 1029
                      :.:|   .|:.|.|..||..|.|.:||||:..|:.:|                  
 Frog   329 ----------EASG---RVSGGVCDNCRDGTTGRNCERCRSDYYRNP------------------ 362

  Fly  1030 CDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGA 1094
                                ..|:.:.:.   |.||:|||.||:....||..||:|:|||.|.|.
 Frog   363 --------------------NKDMSHRDA---CISCDCDPEGSIDGGSCDDLTGRCNCKENVGGE 404

  Fly  1095 KCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVG-SL 1158
            :|.:|:.||:.::|                            .:|.     .|.:|.|:..| ..
 Frog   405 RCDQCKPGYYLLSA----------------------------SNPQ-----GCTKCTCNPQGMER 436

  Fly  1159 SSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIG 1223
            ...||..||||.||.||.|:|||:|...||||.:|.||..|.|.|..|...:||..||||.|:.|
 Frog   437 DQPCDSETGQCKCLPNVLGQRCDQCATNHWNLASGRGCERCGCHPRNSYSLQCNQATGQCLCREG 501

  Fly  1224 VGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR 1288
            .||:.|.||.:..:|                                               ..:
 Frog   502 FGGRFCTECPDRMYG-----------------------------------------------SLQ 519

  Fly  1289 LGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRRCGCDAEGSFTQAD 1352
            .|||.|.||..|::.|.|...:|:|.||.|.:|.:||:|..||.. :|.||.|    ...|...|
 Frog   520 TGCRACNCDFQGTLEQGCDKANGRCLCRPGITGVRCDSCQRGYSDPFPTCRAC----HQCFHFYD 580

  Fly  1353 GSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMA 1417
            ..|.              .|:..|  ||...::               :|:.:.|||..|. |||
 Frog   581 HEIN--------------ALRSHT--QSLLNMT---------------TGQGQDSDLGLGP-RMA 613

  Fly  1418 --ESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQ 1480
              |:....||:|.. ..|..|.|           ..|.::::.||.         |:.       
 Frog   614 AVEAALQRVQRIST-GTPIPDNE-----------LSRAESKLSRMR---------GDA------- 650

  Fly  1481 FYHPLYFQLP-PQFYGDRTSSYGGFLYFTLITEGAHKPLERNI---LGQYPLVQLHAHSKLLLDF 1541
              ..|...|| |:.:.                     ||..||   .||:..:.|          
 Frog   651 --QQLNTNLPEPESFA---------------------PLSNNIHSLRGQFNRINL---------- 682

  Fly  1542 YEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIR-AFAFADFQEVVLQN 1605
                             |::|..:.|.:|.:.|.:.:..|:.:.....:. |.:.|..:.|:.|:
 Frog   683 -----------------LYQSKKEQHSSSISNDASGIFMAVNSAYQSSLESAKSIAAAEGVLSQS 730

  Fly  1606 VHMDA---AIYIKG-STNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGR 1666
              .|:   |:.::| ||.|:| .:|..|     :.||          :.|.|        ..|.|
 Frog   731 --KDSRRVALGLEGKSTELLA-DLETLK-----EELS----------YPNLT--------PTINR 769

  Fly  1667 AAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGC 1731
                              :|                ||...||.:|   :.||.|...||....|
 Frog   770 ------------------IC----------------EGVRIDPCTP---EECPGPVCQRNNNSLC 797

  Fly  1732 NVWDGEVSCVCKPGYTGRLCERCQAGYF---GDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCY 1793
            .|              |.||.    |.|   .:.:|....|.|.                     
 Frog   798 KV--------------GSLCR----GAFPLSSNALRNTEKTSQD--------------------- 823

  Fly  1794 CREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKL 1858
                                                  ::.:.|||::....:.           
 Frog   824 --------------------------------------LQDINNKLQKNALMIQ----------- 839

  Fly  1859 SEYESAYEKWNGRHWDFSQTKRRLQDYD---SADILKLEAHAENLKFQSRKAVATIGKREFAIKS 1920
                           |..:|..::||..   :..:.:..:..|.....||:.:..:  |:|..:.
 Frog   840 ---------------DAEKTASQIQDNAKQLTEQVSRARSRMEEDMGHSRQFIQQV--RDFLTEP 887

  Fly  1921 MREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRST 1985
            ..:.|..|:.|..:|.                   |.|||   .|...|:.:.|       |||.
 Frog   888 STDPATIQEVSEYILS-------------------LKLPT---DASSILRKMNE-------IRSI 923

  Fly  1986 NDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRN 2050
                                 :|:|..:...|:||...:...:......:...|:|:||.:.|..
 Frog   924 ---------------------AGKLPNIDSVLSQTKDDIAKAKKLQSEAELARNKAKDVEDGVDG 967

  Fly  2051 LSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGV 2115
            :.:.:.::...|.|...:|                          .|..:.|             
 Frog   968 VIMNLSQAKTALQEAEDKI--------------------------RGSSSSL------------- 993

  Fly  2116 KTEQQREVRKHWLPKAEKHASHLLARSNEYARKF--------QPTRNGARIAMLASSAHSNITEA 2172
               ||.:.|.|.:.:....|...|...::..::|        :.|....|   |||.||    :|
 Frog   994 ---QQIQNRMHEIEEVLSPAERGLTDMHDQIQQFTAQVEKLREKTVENQR---LASEAH----QA 1048

  Fly  2173 INDARLASILAKERVYEAQRTLY---------PSDGSSMIERAKHSLHRSKQLQQEALKQMHKSN 2228
            ...|...::.|::.: :|.:|.|         .|:..:..|:..:....:.:|.||:::.|:|..
 Frog  1049 AQGANGKALEAQQGL-DAMKTKYALLKSRLGQSSNLGAQGEKIANIKMEADRLIQESIQMMNKMK 1112

  Fly  2229 VLKDKLHRQEQ-------QVEGIKSTIYDSGLRTNNIS 2259
            |::.:|....:       |:||::.   ::.|..:|||
 Frog  1113 VIETELQEGRETLLMKFSQLEGLEE---EAKLIRDNIS 1147

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012 21/64 (33%)
Laminin_EGF <943..971 CDD:278482 0/27 (0%)
VSP 953..1414 CDD:146106 119/462 (26%)
Laminin_EGF 974..1018 CDD:278482 14/43 (33%)
EGF_Lam 1017..1065 CDD:238012 2/47 (4%)
Laminin_EGF 1065..>1105 CDD:278482 20/39 (51%)
EGF_Lam 1150..1197 CDD:238012 24/47 (51%)
Laminin_EGF 1199..1247 CDD:278482 18/47 (38%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 21/48 (44%)
Laminin_EGF 1340..1392 CDD:278482 8/51 (16%)
Laminin_B 1486..1611 CDD:278481 21/132 (16%)
EGF_Lam 1669..1716 CDD:238012 6/46 (13%)
Laminin_EGF 1718..1767 CDD:278482 13/51 (25%)
EGF_Lam 1772..1819 CDD:238012 0/46 (0%)
CrfC <1933..2267 CDD:223771 62/351 (18%)
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
lamb3XP_012826649.2 Laminin_N 26..244 CDD:395009
EGF_Lam 245..302 CDD:238012 19/56 (34%)
EGF_Lam 311..369 CDD:238012 22/154 (14%)
Laminin_EGF 375..424 CDD:395007 22/81 (27%)
Laminin_EGF 427..474 CDD:395007 23/46 (50%)
Laminin_EGF 477..525 CDD:395007 21/94 (22%)
EGF_Lam 525..569 CDD:214543 18/43 (42%)
Smc <815..1149 CDD:224117 80/523 (15%)
cc_LAMB_C 1087..1157 CDD:424069 15/64 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11227
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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