DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbr and Nxf2

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001276664.1	Gene:	Nxf2 / 83454	MGIID:	1933192	Length:	691	Species:	Mus musculus

Alignment Length:	760	Identity:	181/760 - (23%)
Similarity:	307/760 - (40%)	Gaps:	218/760 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRG----GGSSQRYNNNVGNGGGRYNAPEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKKDIK 63
            |||    .....|.||:..:.|..|          ....:||::|           |.::.:..
Mouse    57 KRGVNYIWSQFDRKNNHFDHYGAPY----------AMGMKRRRER-----------CSYDDQYF- 99

  Fly    64 LRPEDLRRWDEDDDMSDMTTAVKDRPTSRRRGSPIPRGKFGKLMPNSFGWYQVTLQNAQIYEKET 128
                 |..||:.......|....:..|..:                   ||:||:.:.:.|||..
Mouse   100 -----LNVWDDSKTEEGETDLDAENETEEK-------------------WYKVTIPSGRKYEKTW 140

  Fly   129 LLSALLAAMSPHVFIPQYWRVERNCVIFFTDDYEAAERIQHLGKNGHLPDGYRLMPRVRSGIPL- 192
            |:.::....| ..|||..:..::....||..:.:.|..::.:        .||:.......|.:
Mouse   141 LMRSIQNFCS-EPFIPVDFHYDKTQARFFVQNAKTASALKDV--------SYRICDETSRKIAIF 196

  Fly   193 -------VAIDDAF----KEKMKVTMAKRYNIQTKALDLSRFHADPDL--KQVFCPLFRQNVMGA 244
                   .::.:.|    .|.::.:|..||:...|||||.:|..|.||  |.:...|.|::.|.|
Mouse   197 VSPSVVPYSVQNKFTSEQMEYIRESMMNRYDASQKALDLEKFRFDQDLMDKDIDMMLNRRSCMVA 261

  Fly   245 AIDIMCDNIPDLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILEL 309
            .:.|:..:||:|.:|||.:|.:..::....:.::.|::|||.|..||:.|...|..::.|.:.||
Mouse   262 TLQIIQSDIPELLSLNLTNNKLYQLDGLSDMTEKAPHVKILNLSRNKLKSFTELEKVKELKLEEL 326

  Fly   310 VLKNNPCRSRYKDSQQFISEVRRKFPKLVKLDGE------------------------------- 343
            .|:.||..:.:.|..::||.:...||||::||||
Mouse   327 WLEGNPFCNCFLDHFEYISTIHDLFPKLLRLDGEDIIVPKRNLQNGKGLIVPTRNLQNGKDLIVP 391

  Fly   344 -------------TLEPQITFDL------SEQGR--LLETK--------ASYLCDVAGAEVVR-- 377
                         |..||...||      .:.|:  ::.||        ....|:.  :||::
Mouse   392 TGNPQDGKDLIVPTGNPQDGKDLIVPTGNPQDGKDLIVPTKMDIEVPQPCKESCNT--SEVIKNL 454

  Fly   378 --QFLDQYFRIFDSGNRQALLDAYHEKAMLSISMP---SASQAGRLNSFWKFNRNLRRLLNGEEN 437
              |||.:|:..:|:|:|..||||||::|..|:|:|   |......|..::|::|:|:| ......
Mouse   455 VLQFLKEYYLFYDNGDRLRLLDAYHDQACFSLSVPFDVSDPNLNNLEEYFKYSRDLKR-QQDSSM 518

  Fly   438 RTRNLKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASMELY 502
            |.:.||:.:...|::|...||||||..:|.|||.::...|:.|:|.|||.|:..:...
Mouse   519 RMQLLKHTKHDIVNSLSLLPKTQHDLCSFLVDLFLHTEMMLCFSVNGLFMEVEGKCRG------- 576

  Fly   503 DVRHFARTYVVVPQNNG-------FCIRNETIFITNATHEQVREFKRSQHQPAPGAMPSTSSAVT 560
            .:|.|.|.::.:|.::.       .||.|:.:.:.||:.::::  |.....|||
Mouse   577 CIRAFTRIFIAIPCSDSRVHSSFRICIMNDELIVRNASPKEIQ--KAFTSLPAP----------- 628

  Fly   561 SPQAGAAAGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTKMQMIE 625
                                                          .|:..|...:|  :.:|::
Mouse   629 ----------------------------------------------DTSFKPLLSEE--QQEMVK 645

  Fly   626 AMSAQSQMNVIWSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAF 670
            :.|.||.|.:.||:|||::..||:..|...|..|..|.|||.|.|
Mouse   646 SFSVQSGMKLDWSQKCLQDNEWDYTKAGEAFTALQNEGKIPKEFF 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	17/78 (22%)
		leucine-rich repeat	215..255	CDD:275382	16/41 (39%)
		LRR_RI	<223..341	CDD:238064	39/119 (33%)
		LRR_8	256..315	CDD:290566	18/58 (31%)
		LRR_4	256..298	CDD:289563	13/41 (32%)
		leucine-rich repeat	256..281	CDD:275382	5/24 (21%)
		leucine-rich repeat	282..305	CDD:275382	8/22 (36%)
		leucine-rich repeat	306..336	CDD:275382	9/29 (31%)
		NTF2	372..531	CDD:238403	54/172 (31%)
		Big_3_5	<578..>614	CDD:293246	2/35 (6%)
		TAP_C	609..671	CDD:197882	23/62 (37%)
Nxf2	NP_001276664.1	Tap-RNA_bind	123..204	CDD:286271	18/108 (17%)
		leucine-rich repeat	230..272	CDD:275382	16/41 (39%)
		LRR_4	271..317	CDD:289563	15/45 (33%)
		leucine-rich repeat	273..298	CDD:275382	5/24 (21%)
		leucine-rich repeat	299..322	CDD:275382	8/22 (36%)
		leucine-rich repeat	323..353	CDD:275382	9/29 (31%)
		NTF2_like	451..606	CDD:298832	51/162 (31%)
		TAP_C	630..691	CDD:197882	24/63 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6110
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	1	1.000	-	-		otm43388
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.930