DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbr and Nxf1

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_067590.2	Gene:	Nxf1 / 59087	RGDID:	62014	Length:	618	Species:	Rattus norvegicus

Alignment Length:	695	Identity:	213/695 - (30%)
Similarity:	330/695 - (47%)	Gaps:	123/695 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRGGGSSQ----RYNNNVGNGGGRYNA---PEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKK 60
            |:|.|..:    ..|...|.||....:   .||..|..:.|.|     :..||.:.|.....|:
  Rat    22 KKGRGPFRWKCGEGNRRSGRGGSGIRSSRFEEDDGDVAMNDPQ-----DGPRVRYNPYTSRPNR- 80

  Fly    61 DIKLRPEDLRR--WDEDDDMSDMTTAVKDRPTSRRRGSPIPRGKFGKLMPNSF-GWYQVTLQNAQ 122
                     ||  |.:.|         :...|.||..:|..||..|.....:. .|:::|:...:
  Rat    81 ---------RRDTWHDRD---------RIHVTVRRDRAPQERGGAGTSQDGTTKNWFKITIPYGK 127

  Fly   123 IYEKETLLSALLAAMS-PHVFIPQYWRVERNCVIFFTDDYEAAERIQHLGKNGHLPDGYRLMPRV 186
            .|:|..|||.:.:..| |  |.|..:..|.....||.:|...|..::.:.......:..|:...:
  Rat   128 KYDKMWLLSMIQSKCSVP--FNPIEFHYENTRAQFFVEDATTASALKAVNYKIQDRENRRISIII 190

  Fly   187 RSGIPLVAIDDAFK----EKMKVTMAKRYNIQTKALDLSRFHADPDL--KQVFCPLFRQNVMGAA 245
            .|..|...:.:..|    |::|:.|:|||:...:||||....:||||  :.:...|.|:..|.||
  Rat   191 NSSAPPYIVQNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRGCMAAA 255

  Fly   246 IDIMCDNIPDLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELV 310
            :.|:.:|||:|.:|||::|.:..::....:.::.||||||.|..|::.|...|..::.|.:.||.
  Rat   256 LRIIEENIPELLSLNLSNNRLYKLDDMSSIVQKAPNLKILNLSGNELKSEWELDKIKGLKLEELW 320

  Fly   311 LKNNPCRSRYKDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQGRLLETKASYLCDVAGAE- 374
            |..||....:.|...:||.:|.:||||::|||..|.|.|.||:.....|...|.||.    |.|
  Rat   321 LDRNPMCDTFLDQSTYISTIRERFPKLLRLDGHELPPPIAFDVEAPTMLPPCKGSYF----GTEN 381

  Fly   375 ---VVRQFLDQYFRIFDSGNRQALLDAYHEKAMLSISMPSASQ---AGRLNSFWKFNRNLRRLLN 433
               :|..||.||:.|:|||:||.||||||:.|..|:|.||..|   ...|..::..:||::: :.
  Rat   382 LKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSTPSNPQNPVRHNLAKYFNDSRNVKK-IK 445

  Fly   434 GEENRTRNLKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPAS 498
            ....|.|.||:.||..|:.|:|.|||.||..:|.||::...::::.|:|.|:|||::.::.:
  Rat   446 DTTTRFRLLKHTRLNVVAFLNELPKTHHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRD--- 507

  Fly   499 MELYDVRHFARTYVVVP-QNNGFCIRNETIFITNATHEQVREFKRSQHQPAPGAMPSTSSAVTSP 562
                .:|.|.||::.|| .|:|.||.|:.:|:.||:.|   |.:|:...|||  .||:|
  Rat   508 ----SLRAFTRTFIAVPASNSGLCIVNDELFVRNASPE---EIQRAFAMPAP--TPSSS------ 557

  Fly   563 QAGAAAGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTKMQMIEAM 627
                                ||..||.:                             :..|::|.
  Rat   558 --------------------PVPTLSQE-----------------------------QQDMLQAF 573

  Fly   628 SAQSQMNVIWSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAFMK 672
            |.||.||:.||:|||::.|||:..:|..|..|..:.:||..||||
  Rat   574 STQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFMK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	18/79 (23%)
		leucine-rich repeat	215..255	CDD:275382	16/41 (39%)
		LRR_RI	<223..341	CDD:238064	42/119 (35%)
		LRR_8	256..315	CDD:290566	19/58 (33%)
		LRR_4	256..298	CDD:289563	14/41 (34%)
		leucine-rich repeat	256..281	CDD:275382	5/24 (21%)
		leucine-rich repeat	282..305	CDD:275382	8/22 (36%)
		leucine-rich repeat	306..336	CDD:275382	10/29 (34%)
		NTF2	372..531	CDD:238403	63/166 (38%)
		Big_3_5	<578..>614	CDD:293246	4/35 (11%)
		TAP_C	609..671	CDD:197882	21/61 (34%)
Nxf1	NP_067590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		27/114 (24%)
		Interaction with ALYREF/THOC4 and LUZP4. /evidence=ECO:0000250\|UniProtKB:Q9UBU9	2..197		46/200 (23%)
		RNA-binding (RBD). /evidence=ECO:0000250	2..117		27/118 (23%)
		Minor non-specific RNA-binding. /evidence=ECO:0000250	2..59		10/36 (28%)
		Major non-specific RNA-binding. /evidence=ECO:0000250	60..117		17/80 (21%)
		RNA binding. /evidence=ECO:0000250	60..117		17/80 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	66..99		11/51 (22%)
		Nuclear export signal. /evidence=ECO:0000250	82..109		9/35 (26%)
		Tap-RNA_bind	115..197	CDD:401194	19/83 (23%)
		leucine-rich repeat	223..265	CDD:275382	16/41 (39%)
		LRR_8	264..326	CDD:404697	21/61 (34%)
		LRR 1	265..290		5/24 (21%)
		leucine-rich repeat	266..291	CDD:275382	5/24 (21%)
		LRR 2	291..314		9/22 (41%)
		leucine-rich repeat	292..315	CDD:275382	8/22 (36%)
		LRR 3	315..342		8/26 (31%)
		leucine-rich repeat	316..346	CDD:275382	10/29 (34%)
		LRR 4	343..370		12/26 (46%)
		NTF2	381..537	CDD:238403	61/163 (37%)
		TAP_C	555..617	CDD:197882	27/116 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5804
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38176
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2894
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	1	1.000	-	-		otm45460
orthoMCL	1	0.900	-	-		OOG6_102057
Panther	1	1.100	-	-	LDO	PTHR10662
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1267
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830