DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sbr and NXF3

DIOPT Version :9

Sequence 1:NP_524660.1 Gene:sbr / 43944 FlyBaseID:FBgn0003321 Length:672 Species:Drosophila melanogaster
Sequence 2:NP_071335.1 Gene:NXF3 / 56000 HGNCID:8073 Length:531 Species:Homo sapiens


Alignment Length:587 Identity:141/587 - (24%)
Similarity:245/587 - (41%) Gaps:134/587 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PKRGGGSSQRYNNNVGNGGGRYNAPEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKKDIKLRP 66
            |.....|.|:.:.:....|...::|..:..:.:....|:....|:                    
Human    39 PGMHSSSHQQQDGDAAMHGAHMDSPVRYTPYTISPYNRKGSFRKQ-------------------- 83

  Fly    67 EDLRRWDEDDDMSDMTTAVKDRPTSRRRGSPIPRGKFGKLMPNSFGWYQVTLQNAQIYEKETLLS 131
                      |.:.:....:.:|..||....:|.|..|       .|:::|:.....|.::.||:
Human    84 ----------DQTHVNMEREQKPPERRMEGNMPDGTLG-------SWFKITVPFGIKYNEKWLLN 131

  Fly   132 ALLAAMS-PHVFIPQYWRVERNCVIFFTDDYEAAERIQHLGKNGHLPDGYRLMPRVR-SGIPLVA 194
            .:....| |  |:|..:..|.....||.::...|..::::.......|..::...|. :|||...
Human   132 LIQNECSVP--FVPVEFHYENMHASFFVENASIAYALKNVSGKIWDEDNEKISIFVNPAGIPHFV 194

  Fly   195 IDDAFKEK---MKVTMAKRYNIQTKALDLSRFHADPDL-----KQVFCPLFRQNVMGAAIDIMCD 251
            ..:...||   :|:.|.::.::..:|||:.|....||:     |....|   :..|.|::|:..:
Human   195 HRELKSEKVEQIKLAMNQQCDVSQEALDIQRLPFYPDMVNRDTKMASNP---RKCMAASLDVHEE 256

  Fly   252 NIPDLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELVLKNNPC 316
            |||.:       .|...|:.:||:|                |.             |.....:|.
Human   257 NIPTV-------MSAGEMDKWKGIE----------------PG-------------EKCADRSPV 285

  Fly   317 RSRYKDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQGRLLET-KASYLCDVAGAEVVR--- 377
            .:.:.|:...|:.:...||||:.|||:. .|:.|...:|..:.|.| |.|:.    |:|:::   
Human   286 CTTFSDTSSNINSILELFPKLLCLDGQQ-SPRATLCGTEAHKRLPTCKGSFF----GSEMLKNLV 345

  Fly   378 -QFLDQYFRIFDSGNRQALLDAYHEKAMLSISMPSASQAGRLNSFWKF---NRNLRRL----LNG 434
             |||.||:.|:|||:||.||.|||::|..|:|:|...:....:||.||   :||::.|    |.|
Human   346 LQFLQQYYLIYDSGDRQGLLSAYHDEACFSLSIPFNPEDSAPSSFCKFFKDSRNIKILKDPYLRG 410

  Fly   435 EENRTRNLKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASM 499
            |     .||:.:|..|.:|...||||||..:|.||:......|:.|:|.|:|||:..::..    
Human   411 E-----LLKHTKLDIVDSLSALPKTQHDLSSFLVDMWYQTEWMLCFSVNGVFKEVEGQSQG---- 466

  Fly   500 ELYDVRHFARTYVVVP-QNNGFCIRNETIFITNATHE----------------QVREFKRSQHQP 547
               .|..|.||::..| .::..||.|:.:|:.:.:|:                .|..|.:.|.:.
Human   467 ---SVLAFTRTFIATPGSSSSLCIVNDKLFVRDTSHQGTQSALFTLVPTAFSSSVPAFSQEQQKM 528

  Fly   548 AP 549
            .|
Human   529 LP 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sbrNP_524660.1 Tap-RNA_bind 112..191 CDD:286271 16/80 (20%)
leucine-rich repeat 215..255 CDD:275382 13/44 (30%)
LRR_RI <223..341 CDD:238064 24/122 (20%)
LRR_8 256..315 CDD:290566 7/58 (12%)
LRR_4 256..298 CDD:289563 6/41 (15%)
leucine-rich repeat 256..281 CDD:275382 5/24 (21%)
leucine-rich repeat 282..305 CDD:275382 1/22 (5%)
leucine-rich repeat 306..336 CDD:275382 5/29 (17%)
NTF2 372..531 CDD:238403 62/170 (36%)
Big_3_5 <578..>614 CDD:293246
TAP_C 609..671 CDD:197882
NXF3NP_071335.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 33..59 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..106 4/52 (8%)
Tap-RNA_bind 110..192 CDD:312616 18/90 (20%)
noncanonical RNP-type RNA-binding (RBD) domain 115..192 16/78 (21%)
leucine-rich repeat (LRR) domains 193..329 38/175 (22%)
leucine-rich repeat 218..260 CDD:275382 13/44 (30%)
leucine-rich repeat 275..305 CDD:275382 6/42 (14%)
nuclear transport factor 2 (NTF2)-like domain 339..461 52/126 (41%)
NTF2 341..496 CDD:238403 60/166 (36%)
ubiquitin-associated domain 524..531 2/7 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 112 1.000 Domainoid score I6196
eggNOG 1 0.900 - - E1_KOG3763
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 277 1.000 Inparanoid score I2942
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1051093at2759
OrthoFinder 1 1.000 - - FOG0000862
OrthoInspector 1 1.000 - - otm41330
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10662
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1267
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.930

Return to query results.
Submit another query.