DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sbr and Nxf1

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_058093.2	Gene:	Nxf1 / 53319	MGIID:	1858330	Length:	618	Species:	Mus musculus

Alignment Length:	687	Identity:	213/687 - (31%)
Similarity:	330/687 - (48%)	Gaps:	122/687 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GSSQRYNNNVGNGGGRYNAPEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKKDIKLRPEDLRR 71
            |...|.:...|:|.......||..|..:.|.|     :..||.:.|         ...||.  ||
Mouse    33 GEGNRRSGRGGSGVQSSRFEEDDGDVAMNDPQ-----DGPRVRYNP---------YTNRPN--RR 81

  Fly    72 WDEDDDMSDMTTAVKDR--PTSRRRGSPIPRGKFGKLMPNSF-GWYQVTLQNAQIYEKETLLSAL 133
            .|...|        :||  .|.||..:|..||..|.....:. .|:::|:...:.|:|..|||.:
Mouse    82 GDGWHD--------RDRIHITVRRDRAPAERGGAGTSQDGTTKNWFKITIPYGRKYDKTWLLSMI 138

  Fly   134 LAAMS-PHVFIPQYWRVERNCVIFFTDDYEAAERIQHLGKNGHLPD--GYRLMPRVRSGIPLVAI 195
            .:..| |  |.|..:..|.....||.:|...|..::  |.|..:.|  ..|:...:.:..|...:
Mouse   139 QSKCSVP--FNPIEFHYENTRAHFFVEDATTASALK--GVNHKIQDRENRRISIIINASAPPYTV 199

  Fly   196 DDAFK----EKMKVTMAKRYNIQTKALDLSRFHADPDL--KQVFCPLFRQNVMGAAIDIMCDNIP 254
            .:..|    |::|:.|:|||:...:||||....:||||  :.:...|.|::.|.|.:.|:.:|||
Mouse   200 QNELKPEQIEQLKLIMSKRYDGNQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIP 264

  Fly   255 DLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELVLKNNPCRSR 319
            :|.:|||:.|.:..::....:.::.||||.|.|..|::.:...|..::.|.:.||.|..||....
Mouse   265 ELLSLNLSSNRLYKLDDMSSIVQKAPNLKTLNLSGNELKTERELDKIKGLKLEELWLDRNPMCDN 329

  Fly   320 YKDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQGRLLETKASYLCDVAGAE----VVRQFL 380
            :.|...:||.:|.:||||::|||..|.|.|:||:.....|...|.||.    |.|    :|.:||
Mouse   330 FGDQSSYISAIRERFPKLLRLDGHELPPPISFDVEAPTMLPPCKGSYF----GTENLKSLVLRFL 390

  Fly   381 DQYFRIFDSGNRQALLDAYHEKAMLSISMPSASQ---AGRLNSFWKFNRNLRRLLNGEENRTRNL 442
            .||:.|:|||:||.||.|||:.|..|:|:|...|   ...|..:.|.:||:::|....: |.|.|
Mouse   391 QQYYVIYDSGDRQGLLYAYHDGACCSLSIPYNPQNPVRKNLAEYVKDSRNVKKLKEPTQ-RFRLL 454

  Fly   443 KYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASMELYDVRHF 507
            |:.||..|:.|:|.||||||...|.||::...::::.|:|.|:|||::.::.:       .:|.|
Mouse   455 KHTRLNVVAFLNELPKTQHDVNAFVVDISAQTSTLLCFSVNGVFKEVDGKSRD-------SLRAF 512

  Fly   508 ARTYVVVP-QNNGFCIRNETIFITNATHEQV-REFKRSQHQPAPGAMPSTSSAVTSPQAGAAAGL 570
            .||::.|| .|:|.||.|:.:|:.||:.|:: |.|..|    ||  .||:|
Mouse   513 TRTFIAVPASNSGLCIVNDELFVRNASPEEIQRAFAMS----AP--TPSSS-------------- 557

  Fly   571 QGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTKMQMIEAMSAQSQMNV 635
                        ||..||.:                             :.:|::|.|.||.||:
Mouse   558 ------------PVPTLSPE-----------------------------QQEMLQAFSTQSGMNL 581

  Fly   636 IWSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAFMK 672
            .||:|||::.|||:..:|..|..|..:.:||..||||
Mouse   582 EWSQKCLQDNNWDYTRSAQAFTLLKAKGEIPEVAFMK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	20/81 (25%)
		leucine-rich repeat	215..255	CDD:275382	15/41 (37%)
		LRR_RI	<223..341	CDD:238064	39/119 (33%)
		LRR_8	256..315	CDD:290566	17/58 (29%)
		LRR_4	256..298	CDD:289563	12/41 (29%)
		leucine-rich repeat	256..281	CDD:275382	5/24 (21%)
		leucine-rich repeat	282..305	CDD:275382	6/22 (27%)
		leucine-rich repeat	306..336	CDD:275382	10/29 (34%)
		NTF2	372..531	CDD:238403	64/166 (39%)
		Big_3_5	<578..>614	CDD:293246	4/35 (11%)
		TAP_C	609..671	CDD:197882	21/61 (34%)
Nxf1	NP_058093.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		27/103 (26%)
		Interaction with ALYREF/THOC4 and LUZP4. /evidence=ECO:0000250\|UniProtKB:Q9UBU9	2..197		48/191 (25%)
		RNA-binding (RBD). /evidence=ECO:0000250	2..117		27/107 (25%)
		Minor non-specific RNA-binding. /evidence=ECO:0000250	2..59		7/25 (28%)
		Major non-specific RNA-binding. /evidence=ECO:0000250	60..117		20/80 (25%)
		RNA binding. /evidence=ECO:0000250	60..117		20/80 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	66..99		14/51 (27%)
		Nuclear export signal. /evidence=ECO:0000250	82..109		10/34 (29%)
		Tap-RNA_bind	115..197	CDD:286271	21/85 (25%)
		leucine-rich repeat	223..265	CDD:275382	15/41 (37%)
		LRR_8	264..326	CDD:290566	19/61 (31%)
		LRR 1	265..290		5/24 (21%)
		leucine-rich repeat	266..291	CDD:275382	5/24 (21%)
		LRR_4	290..328	CDD:289563	14/37 (38%)
		LRR 2	291..314		7/22 (32%)
		leucine-rich repeat	292..315	CDD:275382	6/22 (27%)
		LRR 3	315..342		8/26 (31%)
		leucine-rich repeat	316..346	CDD:275382	10/29 (34%)
		LRR 4	343..370		12/26 (46%)
		NTF2	381..537	CDD:238403	62/163 (38%)
		TAP_C	555..617	CDD:197882	27/116 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6110
eggNOG	1	0.900	-	-		E1_KOG3763
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38176
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	1	1.000	-	-		otm43388
orthoMCL	1	0.900	-	-		OOG6_102057
Panther	1	1.100	-	-	LDO	PTHR10662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R710
SonicParanoid	1	1.000	-	-		X1267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.850