DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbr and Nxf3

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001287064.2	Gene:	Nxf3 / 317878	FlyBaseID:	FBgn0263232	Length:	615	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	141/625 - (22%)
Similarity:	253/625 - (40%)	Gaps:	115/625 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NAPEDFDDFDVEDRQRRKDRN-KRRVSFKPSQCLHNKKDIKLRPEDLRRWDEDDDMSDMTTAVKD 87
            |:....||.       ||:.| |.::.....:.:.|::.:....:.:...:||..::.:|
  Fly    25 NSQSPLDDL-------RKNLNEKSKIREYVQELIGNEQQMGSVLDTISSTEEDHRVATVT----- 77

  Fly    88 RPTSRRRGSPIPRGKFGKLMPNSFGWYQVTLQNAQIYEKETLLSALLAAMSP---HVFIPQYWRV 149
                                    ||..|.:.|.......::..||...|.|   .:|..:....
  Fly    78 ------------------------GWSTVNIANCAGVSNSSIFVALKWVMMPIKVEIFNFKRSGP 118

  Fly   150 ERNCV--IFFTDDYEAAERIQHLGKN-GHLPDGYRLMPRVRSGIP----LVAIDDAFKEKMKVTM 207
            |.|..  .|..|:..:|.|::.|.:. ..:....::..||..|:|    ...|.|.|...::..:
  Fly   119 EDNMARGQFLLDNLLSANRLKRLQEEVAVINTCQKIEVRVTPGLPKSMMCAQITDEFTTAIQEAL 183

  Fly   208 AKRYNIQTKALDLSRFHADPDLKQVFCPLFRQNVMGAAIDIMCDNIPDLEALNLNDNSISSMEAF 272
            ..||.:.::.||||||||.|:|...||||....::...:.:.....|.:.:|.|::|.:.|::||
  Fly   184 RSRYEVDSRTLDLSRFHASPELSLHFCPLHMVKLLETVLVLSNHLFPHVTSLVLSNNYLCSLKAF 248

  Fly   273 KGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELVLKNNPCRSRYKDSQQFISEVRRKFPKL 337
            .|..:...:|:.|.:..|:|..|..|..:..||...:.|..|..      ::..:..:|:..|:|
  Fly   249 AGNSQSFASLERLDISANRIQDLGELNYINKLSCKTIFLAGNGL------AKLSVDVIRKMLPQL 307

  Fly   338 ------VKLDGETLEPQITFDLSEQGRLLETKASYLCDVAGAEVVRQFLDQYFRIFDSGNRQALL 396
                  |:| ||:.|.......|:|.:...|.....|        :.|:..|:..||....:..|
  Fly   308 KNVHGCVQL-GESTEAVDNIPKSQQLQGGGTNGLKFC--------QDFISSYYTFFDDTEERFKL 363

  Fly   397 DAYH-EKAMLSISMPSASQAGRLNSFWKFNRNLRRLLNGEENRTRNLKYGRLACVSTLDEWPKTQ 460
            ..|: ::||.|:|:|  .|...:..:..:|||.:| .:....:...|:.||.|.:..|...|...
  Fly   364 KKYYDDQAMFSLSVP--VQLNYVYGYKLYNRNQKR-QHSSFAQNAKLQVGRAALLLALSRLPLMH 425

  Fly   461 HDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASMELYDVRHFARTYVVVPQNN-GFCIRN 524
            .|.....:|:.::.:|:.:||:||.|||::.:|..|        |.|.||:|:...|: |:.|.|
  Fly   426 TDLENVGLDIQVFTSSLRIFTLTGYFKEISSDTLEP--------RRFQRTFVLQTSNSPGWLITN 482

  Fly   525 ETIFITNATHEQVREFK--------------RSQHQPAPGAMPSTSS---AVTSPQAGAAAGLQG 572
            :.:.||:...:..:..|              ...::||...:...|.   .::.|.:|.
  Fly   483 DMLCITSTMPDPKKTIKFKPETNMINTDPSVEKINKPAVTVLDRKSKEDVQISRPLSGK------ 541

  Fly   573 RLNALGVATGPVAILSGD-----------PLAATAPVNSG 601
            .||.|..|...:::...|           ||.|..|:.:|
  Fly   542 ELNPLNKAVQKMSLSQVDHLPSENFNDMPPLVAIGPLTTG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	19/84 (23%)
		leucine-rich repeat	215..255	CDD:275382	14/39 (36%)
		LRR_RI	<223..341	CDD:238064	31/123 (25%)
		LRR_8	256..315	CDD:290566	16/58 (28%)
		LRR_4	256..298	CDD:289563	12/41 (29%)
		leucine-rich repeat	256..281	CDD:275382	7/24 (29%)
		leucine-rich repeat	282..305	CDD:275382	6/22 (27%)
		leucine-rich repeat	306..336	CDD:275382	3/29 (10%)
		NTF2	372..531	CDD:238403	44/160 (28%)
		Big_3_5	<578..>614	CDD:293246	7/35 (20%)
		TAP_C	609..671	CDD:197882
Nxf3	NP_001287064.2	leucine-rich repeat	191..231	CDD:275382	14/39 (36%)
		PPP1R42	<192..296	CDD:411060	32/109 (29%)
		leucine-rich repeat	232..257	CDD:275382	7/24 (29%)
		leucine-rich repeat	258..281	CDD:275382	6/22 (27%)
		NTF2_like	338..489	CDD:415585	45/169 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	1	1.000	-	-		otm47194
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950