DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbr and nxf-1

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_001129880.1	Gene:	nxf-1 / 191736	WormBaseID:	WBGene00003834	Length:	609	Species:	Caenorhabditis elegans

Alignment Length:	705	Identity:	166/705 - (23%)
Similarity:	282/705 - (40%)	Gaps:	147/705 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NNVGNGGGRYNAPEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKKDIKLRPEDLRRWDEDDDM 78
            |..|.||.|          |.:...|.|:|..|                 |.|:...|:::||:.
Worm     2 NRKGFGGHR----------DAKQLSRTKNRFAR-----------------LDPDTQSRYEDDDEP 39

  Fly    79 SDMTTAVKDRPTSRRRGSPIPRGKFGKLMPNSFGWYQVTLQNAQIYEKETLLSA--------LLA 135
            :....|.....:||.||.. .|| ||:   ::.......::||.|..|.....|        |:.
Worm    40 AVPVRASLTSASSRGRGGS-SRG-FGQ---SAASIANTGVRNADIVYKCRATGAAKKVDAKWLIK 99

  Fly   136 AMSPHV--FIPQYWRVE-RNCVIFFTDDYEAAERIQHLGKN-GHLPDGYRL-----------MPR 185
            .::..:  |.|..|... |....::..|.:.|..|:...:. .|...|.|:           |..
Worm   100 QLNQIIENFKPLLWTDNARGDFEWYVRDEDTASTIRANNRRVVHKESGTRVEFYTSKVPAPWMKL 164

  Fly   186 VRSGIPLV--AIDDAFKEKMKVTMAKRYNIQTKALDLSRFHADPDL--KQVFCPLFRQNVMGAAI 246
            .|..|.::  .:|            ||:|.:.:.||||.||.|.:.  |.:...|.:.|||...:
Worm   165 KREEIEIIHRVVD------------KRHNAENRVLDLSNFHEDEEFKAKDMMMNLTKGNVMLTVL 217

  Fly   247 DIMCDNIPDLEALNLNDNSISSME---AFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILE 308
            |.:.|...::.||:|::|.|..::   |...:.|.:..|.   |..|.|.:...|.....|.:..
Worm   218 DHIDDKYGNIVALSLSNNRIRHLDYASALVSIAKFVMELD---LSHNHISTEKELEKFAGLPVER 279

  Fly   309 LVLKNNPCRSRYKDSQQFISEVRRKFPKLVKLDGETLEPQIT---FDLSEQGRLLETKASYLCDV 370
            ...:.||....:.....:||.:.:.||:...|||..::|.:.   .|:.:   .:..:|.|..:.
Worm   280 FFFEGNPVVESFTQRAAYISYIHQSFPRCNMLDGVEVQPLVVGPDLDIHD---AMPFRAGYYPNP 341

  Fly   371 AGAEVVRQFLDQYFRIFDSGN----RQALLDAYHEKA---MLSIS-MPSASQAGRLNS--FWKF- 424
            ....:|.||:..||..:|..:    |:.|.:||...|   .|:|. :..:|.|...|.  |.::
Worm   342 QIRVLVEQFVTSYFDFYDGPDGQRTRRNLHNAYDADASTFSLTIEHLRGSSHARHHNDECFAQYA 406

  Fly   425 --NRNLRRLLNGEENRTRNLKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFK 487
              :.|:.:......:|......|.:.....|.:.|.:.|.|.||.||:.:.:..::.|||.|||.
Worm   407 GVSHNVLKQERFARHRASRSARGAMDIAVALSKLPTSSHMRDTFIVDVFLQSNDLLGFTVQGLFC 471

  Fly   488 ELNDETNNPASMELYDVRHFARTYVVVP-QNNGFCIRNETIFITNATHEQVREFKRSQHQP-APG 550
            : .|.|..|:.      ..|:|:::|.| :|:...:.::.:|||.|:.:::.:||:...|. |.|
Worm   472 D-GDLTQTPSP------SFFSRSFLVSPRENDSVAVISDQLFITVASLDRLEKFKKLYDQSIANG 529

  Fly   551 AMPSTSSAVTSPQAGAAAGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQ 615
            |.....|||...|.|        :|.:|....|           ..|:
Worm   530 AAVEQVSAVQIAQIG--------VNGMGFDGAP-----------ALPI----------------- 558

  Fly   616 DESTKMQMIEAMSAQSQMNVIWSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAF 670
                :.:||:||...|.|...:|.|||.:..|:|:.|...|.::  ::.:|.|||
Worm   559 ----REEMIKAMCQFSGMIPPFSEKCLADCAWNFDFACQKFNEI--KSSVPAEAF 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	18/101 (18%)
		leucine-rich repeat	215..255	CDD:275382	14/41 (34%)
		LRR_RI	<223..341	CDD:238064	29/122 (24%)
		LRR_8	256..315	CDD:290566	13/61 (21%)
		LRR_4	256..298	CDD:289563	11/44 (25%)
		leucine-rich repeat	256..281	CDD:275382	7/27 (26%)
		leucine-rich repeat	282..305	CDD:275382	5/22 (23%)
		leucine-rich repeat	306..336	CDD:275382	5/29 (17%)
		NTF2	372..531	CDD:238403	44/172 (26%)
		Big_3_5	<578..>614	CDD:293246	3/35 (9%)
		TAP_C	609..671	CDD:197882	18/62 (29%)
nxf-1	NP_001129880.1	leucine-rich repeat	184..226	CDD:275382	14/41 (34%)
		leucine-rich repeat	227..252	CDD:275382	6/24 (25%)
		leucine-rich repeat	253..276	CDD:275382	5/25 (20%)
		leucine-rich repeat	277..307	CDD:275382	5/29 (17%)
		TAP_C	550..608	CDD:197882	20/92 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38176
Inparanoid	1	1.050	117	1.000	Inparanoid score	I3370
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46704
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	1	1.000	-	-		otm14803
orthoMCL	1	0.900	-	-		OOG6_102057
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R710
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010