DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sbr and LOC100490733

DIOPT Version :9

Sequence 1:	NP_524660.1	Gene:	sbr / 43944	FlyBaseID:	FBgn0003321	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	XP_004914856.2	Gene:	LOC100490733 / 100490733	-ID:	-	Length:	658	Species:	Xenopus tropicalis

Alignment Length:	672	Identity:	168/672 - (25%)
Similarity:	281/672 - (41%)	Gaps:	128/672 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KRRVSFKPSQCLHNKKDIKLRPEDLRR-------WDEDDD-----MSDMTTAVKDRPTSRRRGSP 97
            |::..|:.....| ::.::|..:..||       .|.|..     ..|.:..::|........:|
Frog    65 KKKKRFRKQSWFH-RRSVQLSVDGRRRVKCNFIECDRDSQGQCPLSLDESNEIEDPYEGGSHLNP 128

  Fly    98 IPRGKFGKLMPNSFGWYQVTLQNAQIYEKETLLSALLAAMSPHVFIPQYWRVERNCVIFFTDDYE 162
            .....:.....|:..|:::|:...:.|.|:.||:|:...........|:..|::..| ||.|.:.
Frog   129 SNGQLYRAKNDNTQVWFKITIPYGKDYNKDWLLNAIREECGLFFRAEQFHYVKKKAV-FFVDKFA 192

  Fly   163 AAERIQHLGKNGHLPDGYRLMPRV------RSGIPLVAIDDAFKEKM------------KVTMAK 209
            .|:.:.:..:.......::::..|      ..|.|.:...||   ||            :..:.|
Frog   193 TAKALLNASRKIQADQYFKIVINVTPSMYRHHGNPTLCHRDA---KMGSLCPGDSLYCIQACLQK 254

  Fly   210 RYNIQTKALDLSRFHADPDLK---QVFCPLFRQNVMGAAIDIMCDNIPDLEALNLNDNSISSMEA 271
            ||:.:|.:||||....||:|:   :..| |.:.:.....:.::.::.|.|.:|:|:.|::||:..
Frog   255 RYDDRTASLDLSNLSIDPELQSTNKCLC-LNQASDAELILQLIAEHFPQLLSLDLSYNNLSSLTD 318

  Fly   272 FKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELVLKNNPCRSRYKDSQQFISEVRRKFPK 336
            |.|:....|.|:.:.|..|:|.....:.||..|.:.||.|:.||..:..:.:..:...|...||.
Frog   319 FSGLSALAPQLQSMNLSYNQICQAQEINVLHKLELKELWLEGNPFLASLESTSTYYRIVMNHFPS 383

  Fly   337 LVKLDGETLEPQITFDLSEQGRLLETKASYLCDVAGAEVVRQFL----DQYFRIFDSGNRQALLD 397
            :..|||...:|...|....:. |.:.|.|:..:    |.:|.||    .:||.|:||..||.||.
Frog   384 VQILDGHFFKPGCFFGKVPRS-LPQIKGSFFVN----EDLRAFLVPFVSRYFTIYDSTQRQQLLP 443

  Fly   398 AYHEKAMLSISMPS-------ASQAGRLNSFWKFNRNLRRLLNGEENRTRNLKYGRLACVSTLDE 455
            .|||....|.|:|:       ..||   ..:.|.||||.|:... ..|.:.:||.||..|..|..
Frog   444 LYHENCCCSFSLPNVLLPHICVEQA---KEYLKENRNLLRVKRA-ALRQQLMKYNRLQVVGFLCN 504

  Fly   456 WPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASMELYDVRHFARTYVVVPQNNGF 520
            .|:|:||..:||:|:.....|::.|:|.|:|||     .:|...:|  .|.|.|::::||....
Frog   505 LPRTEHDLSSFTLDVWFQTPSLIGFSVAGIFKE-----ESPKWKKL--CRSFRRSFLIVPAMEA- 561

  Fly   521 C--IRNETIFITNATHEQVREFKRSQHQPAPGAMPSTSSAVTSPQAGAAAGLQGRLNALGVATGP 583
            |  |.|:.:.|.|:..:|. |.|.....|.||:..|.
Frog   562 CAQILNDQLVIINSYVDQY-EDKCGPASPDPGSPGSN---------------------------- 597

  Fly   584 VAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTKMQMIEAMSAQSQMNVIWSRKCLEETNWD 648
            ||:..|:                              |.::...|..:.|.|.|:.||||:.||:
Frog   598 VALCDGN------------------------------MAVLRNFSESTGMKVEWALKCLEDNNWN 632

  Fly   649 FNHAAFVFEKLFKENKIPPEAF 670
            ...|..||..|.::..||.:||
Frog   633 VEQAQDVFSLLKEKGTIPQDAF 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sbr	NP_524660.1	Tap-RNA_bind	112..191	CDD:286271	16/84 (19%)
		leucine-rich repeat	215..255	CDD:275382	10/42 (24%)
		LRR_RI	<223..341	CDD:238064	30/120 (25%)
		LRR_8	256..315	CDD:290566	19/58 (33%)
		LRR_4	256..298	CDD:289563	13/41 (32%)
		leucine-rich repeat	256..281	CDD:275382	8/24 (33%)
		leucine-rich repeat	282..305	CDD:275382	6/22 (27%)
		leucine-rich repeat	306..336	CDD:275382	7/29 (24%)
		NTF2	372..531	CDD:238403	59/171 (35%)
		Big_3_5	<578..>614	CDD:293246	3/35 (9%)
		TAP_C	609..671	CDD:197882	19/62 (31%)
LOC100490733	XP_004914856.2	Tap-RNA_bind	144..220	CDD:401194	15/76 (20%)
		LRR	258..>362	CDD:227223	30/104 (29%)
		leucine-rich repeat	260..302	CDD:275382	10/42 (24%)
		LRR_8	<299..339	CDD:404697	13/39 (33%)
		leucine-rich repeat	303..328	CDD:275382	8/24 (33%)
		leucine-rich repeat	329..352	CDD:275382	6/22 (27%)
		leucine-rich repeat	353..383	CDD:275382	7/29 (24%)
		NTF2_like	425..574	CDD:415585	55/160 (34%)
		UBA_TAP-C	606..654	CDD:270527	16/47 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3032
OMA	1	1.010	-	-		QHG46704
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	1	1.000	-	-		otm48532
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080