DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment or and AP3S2

DIOPT Version :9

Sequence 1:	NP_536793.1	Gene:	or / 43943	FlyBaseID:	FBgn0003008	Length:	191	Species:	Drosophila melanogaster
Sequence 2:	NP_005820.1	Gene:	AP3S2 / 10239	HGNCID:	571	Length:	193	Species:	Homo sapiens

Alignment Length:	193	Identity:	147/193 - (76%)
Similarity:	169/193 - (87%)	Gaps:	7/193 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKAILVFNNHGKPRLSKFYQYFDESLQQQIIKETFQLVSKRDDNVCNFLEGGSLIGGSDYKLIY 65
            ||:|||||||||||||.:|||.|.|.:||||::|||.||.|||||:|||||||||||||||||||
Human     1 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIY 65

  Fly    66 RHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHADAVHHILSELVMGGMVL 130
            |||||||||||||||||||||||||||||||||||||||||||||||.|.||:||.|:|||||||
Human    66 RHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVL 130

  Fly   131 QTNMNDIMARIEEQNKIVKQEAGISAAPARAVSAVKSMNIPQ-----QIKD--IKLPDLPQAI 186
            :||||:|:|:||.||::.|.|.|:||||||||||||::|:|:     .|.|  ||:|:|.|.:
Human   131 ETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQFV 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
or	NP_536793.1	AP3_sigma	1..146	CDD:341438	122/144 (85%)
AP3S2	NP_005820.1	AP3_sigma	1..146	CDD:341438	122/144 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148029
Domainoid	1	1.000	259	1.000	Domainoid score	I2003
eggNOG	1	0.900	-	-		E1_COG5030
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100592
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53551
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002758
OrthoInspector	1	1.000	-	-		otm40337
orthoMCL	1	0.900	-	-		OOG6_102376
Panther	1	1.100	-	-	LDO	PTHR11753
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R65
SonicParanoid	1	1.000	-	-		X1844
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790