DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and MAE1

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_012896.1	Gene:	MAE1 / 853839	SGDID:	S000001512	Length:	669	Species:	Saccharomyces cerevisiae

Alignment Length:	622	Identity:	221/622 - (35%)
Similarity:	323/622 - (51%)	Gaps:	67/622 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KTAVA--AATVPTARHYH----EVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQ 82
            ||.|.  |..:..|.|.|    .|.|.|.||  :.....:..|..|||.|||.|||:...:..|.
Yeast    67 KTPVGSRARKIFEAPHPHATRLTVEGAIECP--LESFQLLNSPLFNKGSAFTQEEREAFNLEALL 129

  Fly    83 PARFKTQEEQL-----QLCKIAVNRYTEPLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTP 142
            |.:..|.:|||     |||.:..     ||.|..:::.|..:|:.|:|..:..:|::|:||:|||
Yeast   130 PPQVNTLDEQLERSYKQLCYLKT-----PLAKNDFMTSLRVQNKVLYFALIRRHIKELVPIIYTP 189

  Fly   143 TVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKNW-PEPNVRAICVTDGERILGLGDLGACGMG 206
            |.|.|...:...:|:|.|:|:...:...|...:..: .:.:|..|.|:|.|.|||:||.|..|:.
Yeast   190 TEGDAIAAYSHRFRKPEGVFLDITEPDSIECRLATYGGDKDVDYIVVSDSEGILGIGDQGIGGVR 254

  Fly   207 IPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVV 271
            |.:.||||.|...||.|.:.||:.:||||||..|..|.||:|.:..|:.|::||:|:::|::||.
Yeast   255 IAISKLALMTLCGGIHPGRVLPVCLDVGTNNKKLARDELYMGNKFSRIRGKQYDDFLEKFIKAVK 319

  Fly   272 QRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFL 336
            :.| .:.::.|||||..||.|.|:|||....:||||||||.:|.:|.|.|:.:.|.:..||...|
Yeast   320 KVY-PSAVLHFEDFGVKNARRLLEKYRYELPSFNDDIQGTGAVVMASLIAALKHTNRDLKDTRVL 383

  Fly   337 FAGAGEAAIGIADLTVKAMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYAKD---- 397
            ..|||.|.:||||..|..||..||..|||..:|:::|..||:.:|.:..:.....: |||.
Yeast   384 IYGAGSAGLGIADQIVNHMVTHGVDKEEARKKIFLMDRRGLILQSYEANSTPAQHV-YAKSDAEW 447

  Fly   398 --INPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDA 460
              ||..| |.::|..:||:.|:|.|..||.||.:::..|..:|.||::|.|||||...|....|.
Yeast   448 AGINTRS-LHDVVENVKPTCLVGCSTQAGAFTQDVVEEMHKHNPRPIIFPLSNPTRLHEAVPADL 511

  Fly   461 YKHTDARVIFSSGSPFPPVQIGDKTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELA 525
            .|.|:...:.::|||||||.    .:...:.||.|.|||:|||.:.:....|.|:|...|..:||
Yeast   512 MKWTNNNALVATGSPFPPVD----GYRISENNNCYSFPGIGLGAVLSRATTITDKMISAAVDQLA 572

  Fly   526 NFVEPSDIERG----SLYPPLSSIRNVSMNIAVGVTKCAYDRGLA-------------STYPEPQ 573
               |.|.:..|    .|.|.|.:|.|.|..:|..|...|.:.|.|             .|...|:
Yeast   573 ---ELSPLREGDSRPGLLPGLDTITNTSARLATAVILQALEEGTARIEQEQVPGGAPGETVKVPR 634

  Fly   574 D---KRKWLENQLYNFNYESSMPASWVWPRMPYIKTR 607
            |   ..:|::.|::...|.            |.||.:
Yeast   635 DFDECLQWVKAQMWEPVYR------------PMIKVQ 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	206/570 (36%)
		malic	117..298	CDD:278802	71/181 (39%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	105/302 (35%)
MAE1	NP_012896.1	PRK13529	91..658	CDD:237414	212/595 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346254
Domainoid	1	1.000	155	1.000	Domainoid score	I893
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I422
Isobase	1	0.950	-	0	Normalized mean entropy	S996
OMA	1	1.010	-	-		QHG60768
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		otm46745
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
TreeFam	1	0.960	-	-
	13	12.640