DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and NADP-ME3

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_197960.1	Gene:	NADP-ME3 / 832657	AraportID:	AT5G25880	Length:	588	Species:	Arabidopsis thaliana

Alignment Length:	543	Identity:	283/543 - (52%)
Similarity:	371/543 - (68%)	Gaps:	2/543 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTEPLNKYLYL 113
            |...|...:||||.|||||||.:||....|.||.|....:|:.|.:.....:.:||.||.:|:.|
plant    45 SVASGYTLMRDPRYNKGLAFTDKERDAHYITGLLPPVVLSQDVQERKVMHNLRQYTVPLQRYMAL 109

  Fly   114 SDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKNW 178
            .||.:||||||::.|.:|:|:|:|:|||||||.|||::|.|||||.||:|:..::|.|.:|:|||
plant   110 MDLQERNERLFYKLLIDNVEELLPVVYTPTVGEACQKYGSIYRRPQGLYISLKEKGKILEVLKNW 174

  Fly   179 PEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLED 243
            |:..::.|.||||||||||||||..|||||||||:|||||.||:|..||||.:||||||..||.:
plant   175 PQRGIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGIRPSACLPITIDVGTNNEKLLNN 239

  Fly   244 PLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDDI 308
            ..|:||:|||..|.||.||:.|||.||.|.||:..|:|||||.||:||..|.||.:::..|||||
plant   240 EFYIGLKQKRANGEEYAEFLQEFMCAVKQNYGEKVLVQFEDFANHHAFELLSKYCSSHLVFNDDI 304

  Fly   309 QGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADL-TVKAMVQDGVPIEEAYNRIYMV 372
            ||||||.:|||.|::::.|||..|:||||.|||||..|||:| .:|...:.|.||:|...:|::|
plant   305 QGTASVVLAGLIAAQKVLGKSLADHTFLFLGAGEAGTGIAELIALKISKETGKPIDETRKKIWLV 369

  Fly   373 DIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADN 437
            |..||:...|| .:|...|..:|.|..|:.:|...|:.|||:||||.|.....||.|::..||..
plant   370 DSKGLIVSERK-ESLQHFKQPWAHDHKPVKELLAAVNAIKPTVLIGTSGVGKTFTKEVVEAMATL 433

  Fly   438 NERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGDKTFYPGQGNNAYIFPGVGL 502
            ||:|::.|||||||:||||||:||..|..|.||:|||||.|||...|.|.|||.||.|||||:||
plant   434 NEKPLILALSNPTSQAECTAEEAYTWTKGRAIFASGSPFDPVQYDGKKFTPGQANNCYIFPGLGL 498

  Fly   503 GVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYDRGLAS 567
            |:|.:|...:.|:|.|.|::.||:.|...:...|.:|||.::||.:|.|||..|....|:.||||
plant   499 GLIMSGAIRVRDDMLLAASEALASQVTEENFANGLIYPPFANIRKISANIAASVGAKTYELGLAS 563

  Fly   568 TYPEPQDKRKWLENQLYNFNYES 590
            ..|.|:|..|..|:.:|:..|.:
plant   564 NLPRPKDLVKMAESCMYSPVYRN 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	282/539 (52%)
		malic	117..298	CDD:278802	112/180 (62%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	135/277 (49%)
NADP-ME3	NP_197960.1	PLN03129	20..588	CDD:215594	283/543 (52%)
		malic	113..293	CDD:278802	111/179 (62%)
		NAD_bind_1_malic_enz	304..582	CDD:133454	136/278 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	263	1.000	Domainoid score	I469
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I249
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm1109
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840