DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and NAD-ME2

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_191966.2	Gene:	NAD-ME2 / 828222	AraportID:	AT4G00570	Length:	607	Species:	Arabidopsis thaliana

Alignment Length:	588	Identity:	238/588 - (40%)
Similarity:	347/588 - (59%)	Gaps:	33/588 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KTAVAAATVPTARHYHEVV-GDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFK 87
            |.|.||.|..:.|.:...: |.  |....||.|.:.||..||...|.|.||..|||.||.|.|..
plant    11 KAAAAARTHGSRRCFSTAIPGP--CIVHKRGADILHDPWFNKDTGFPLTERDRLGIRGLLPPRVM 73

  Fly    88 TQEEQLQLC--------KIAVNRYTEPLN-----KYLYLSDLYDRNERLFFRFLSENIEDLMPIV 139
            |..:|   |        .:..|...||.|     |:..|:.|:||||.|::|.|.:||:|..||:
plant    74 TCVQQ---CDRFIESFRSLENNTKGEPENVVALAKWRMLNRLHDRNETLYYRVLIDNIKDFAPII 135

  Fly   140 YTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACG 204
            |||||||.||.:..:||||.|::.:..|:|.:..::.|||.|.|..|.:|||.|||||||||..|
plant   136 YTPTVGLVCQNYSGLYRRPRGMYFSAKDKGEMMSMIYNWPAPQVDMIVITDGSRILGLGDLGVQG 200

  Fly   205 MGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEA 269
            :|||:|||.:|.|.|||.|.:.|||::||||||..||::.||:|:||.|:.|.||.|.|||||||
plant   201 IGIPIGKLDMYVAAAGINPQRVLPIMLDVGTNNEKLLQNDLYLGVRQPRLEGEEYLEIIDEFMEA 265

  Fly   270 VVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYT 334
            ...|: ...::|||||....||..|::||..:|.||||:||||.||:|||..:.|..|:...|:.
plant   266 AFTRW-PKAVVQFEDFQAKWAFGTLERYRKKFCMFNDDVQGTAGVALAGLLGTVRAQGRPISDFV 329

  Fly   335 ---FLFAGAGEAAIGIADLTVKAMVQ-DGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYA 395
               .:..|||.|.:|:..:.|:|:.: .|:...||....|::|.|||:|..|.  .||...:.:|
plant   330 NQKIVVVGAGSAGLGVTKMAVQAVARMAGISESEATKNFYLIDKDGLVTTERT--KLDPGAVLFA 392

  Fly   396 K---DINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADNNE-RPVVFALSNPTSKAECT 456
            |   :|...:.:.|:|..::|.||:|.|...|||..|:|:.|.:::. :|.:||:||||..||||
plant   393 KNPAEIREGASIVEVVKKVRPHVLLGLSGVGGIFNEEVLKAMRESDSCKPAIFAMSNPTLNAECT 457

  Fly   457 AEDAYKHTDARVIFSSGSPFPPVQI-GDKTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIA 520
            |.||:||....::|:|||||..|:: ..|..:..|.||.|:|||:|||.:.:|...:.|.|...|
plant   458 AADAFKHAGGNIVFASGSPFENVELENGKVGHVNQANNMYLFPGIGLGTLLSGARIVTDGMLQAA 522

  Fly   521 AQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYDRGLASTYPE--PQDKRKWLENQL 583
            ::.||:::...::::|.|||.:::||:::..:...|.:.|....:|..:.:  |:|.....:...
plant   523 SECLASYMTDEEVQKGILYPSINNIRHITAEVGAAVLRAAVTDDIAEGHGDVGPKDLSHMSKEDT 587

  Fly   584 YNF 586
            .|:
plant   588 VNY 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	230/560 (41%)
		malic	117..298	CDD:278802	96/180 (53%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	98/287 (34%)
NAD-ME2	NP_191966.2	PLN03129	17..604	CDD:215594	234/582 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D435571at2759
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690