DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and me2

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001015690.1	Gene:	me2 / 548395	XenbaseID:	XB-GENE-943055	Length:	583	Species:	Xenopus tropicalis

Alignment Length:	555	Identity:	290/555 - (52%)
Similarity:	395/555 - (71%)	Gaps:	12/555 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HIRD--------PRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTEPLNKYLY 112
            |.:|        ||.|||:||||:|||.||:.||.|.:.::|:.|.......:::..:||.||:|
Frog    20 HTKDKGKALLLNPRTNKGMAFTLQERQILGLQGLLPPKVESQDIQAARFHRNLSKMEDPLQKYIY 84

  Fly   113 LSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKN 177
            :..:.:|||:||:|.|.::||.||||||||||||||.::|..:|||.||:|:..|||||..::.:
Frog    85 IMGIQERNEKLFYRILLDDIEHLMPIVYTPTVGLACSQYGHTFRRPKGLYISILDRGHIRSILDH 149

  Fly   178 WPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLE 242
            |||.:|:|:.|||||||||||:||..|||||||||.||||.|||:|.:|||:|:||||:|..||:
Frog   150 WPETDVKAVVVTDGERILGLGNLGVYGMGIPVGKLCLYTACAGIRPQKCLPVVIDVGTDNPTLLK 214

  Fly   243 DPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDD 307
            ||.|:||.|||...:.||:.|||||:||..||||||||||||||||||||||.|||..|||||||
Frog   215 DPFYMGLYQKRDRTQLYDDLIDEFMDAVTDRYGQNTLIQFEDFGNHNAFRFLRKYREKYCTFNDD 279

  Fly   308 IQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNRIYMV 372
            ||||||||:||:.|:::..||...::..||.||||||:|||:|.|.:|:::|:..|.|..||:|.
Frog   280 IQGTASVALAGMLAAQKAIGKPITEHKILFLGAGEAALGIANLIVMSMMENGISAEAARERIWMF 344

  Fly   373 DIDGLLTKSRKVGNLDGHKIHYAKDI--NPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMA 435
            |..|||.:.|..| :|.::..:|...  ..:....:.|..::|:.:||.:.|..:||.::::.||
Frog   345 DKFGLLIQGRGEG-IDSNQESFAHSAPEQAVGSFLDAVKVLQPTAIIGVAGAGKLFTEDVIKEMA 408

  Fly   436 DNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGD-KTFYPGQGNNAYIFPG 499
            ..||||::|||||||.|||||||:||..|:.:.:|:|||||..|.:.| ::|.||||||||||||
Frog   409 SINERPIIFALSNPTVKAECTAEEAYTWTEGQCLFASGSPFDTVTLSDGRSFKPGQGNNAYIFPG 473

  Fly   500 VGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYDRG 564
            |.|.||.:|..||.|.:||.||:.||..:...::.:|.||||||:||.||:.|||.|.:..|..|
Frog   474 VALAVILSGVRHISDRVFLEAAKALAEQLTAEELGQGRLYPPLSNIREVSICIAVKVMEFVYRNG 538

  Fly   565 LASTYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            :|..||||..|..::.:::::.:|:|..|..:.||
Frog   539 MAFQYPEPVGKNAYIRSKVWSTDYDSFPPDVYDWP 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	286/544 (53%)
		malic	117..298	CDD:278802	121/180 (67%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	129/279 (46%)
me2	NP_001015690.1	PLN03129	25..565	CDD:215594	284/540 (53%)
		malic	89..270	CDD:278802	121/180 (67%)
		NAD_bind_1_malic_enz	280..560	CDD:133454	129/280 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I836
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9538
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060