DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and me3

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001082825.1	Gene:	me3 / 492719	ZFINID:	ZDB-GENE-041111-294	Length:	603	Species:	Danio rerio

Alignment Length:	597	Identity:	323/597 - (54%)
Similarity:	418/597 - (70%)	Gaps:	26/597 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSLCGTVGKLCRCGTSATGKTAVAAATVPTARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFT 69
            |::.|.| ::|..|.::.|       ||.|.:               ||.|..|:|.||||:|||
Zfish    24 PAMVGAV-RVCHTGVNSKG-------TVFTRK---------------RGYDITRNPHLNKGMAFT 65

  Fly    70 LEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTEPLNKYLYLSDLYDRNERLFFRFLSENIED 134
            ||||..||||||.|..|.:|:.|:.....:....:.||:||:.|..|.||||:||:|.|:.:||:
Zfish    66 LEERLQLGIHGLLPPCFLSQDVQVLRVMKSYETRSNPLDKYILLMTLQDRNEKLFYRVLTSDIEE 130

  Fly   135 LMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGD 199
            .||||||||||||||::||.:|||.|||||.:|:|||..::.:|||.:::||.||||||||||||
Zfish   131 FMPIVYTPTVGLACQQYGLAFRRPRGLFITIHDKGHIATMLNSWPEEDIKAIVVTDGERILGLGD 195

  Fly   200 LGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFID 264
            ||..||||||||||||||..|:.|.||||:::||||:|..||:||||:||:.|||.|:|||:.||
Zfish   196 LGGYGMGIPVGKLALYTACGGVPPQQCLPVLLDVGTDNQTLLDDPLYIGLKHKRVRGKEYDDLID 260

  Fly   265 EFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKS 329
            |||:||..:||.|.|||||||.|.||||.|:||||.||||||||||||||||||:.|:.:||...
Zfish   261 EFMQAVTDKYGMNCLIQFEDFANSNAFRILNKYRNRYCTFNDDIQGTASVAVAGILAALKITKNK 325

  Fly   330 FKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHY 394
            ..|:.|:|.||||||:|||.|.:.||.::|:|..||..||:|||..||:.|.|  .:|:..|..:
Zfish   326 LSDHKFVFQGAGEAALGIAHLLIMAMAKEGIPHAEAAQRIWMVDSKGLIVKGR--SHLNHEKEEF 388

  Fly   395 AKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAED 459
            |.|...:..|.|:|.||||:.:||.:|..|.||.:|::.||.|||||::|||||||||||||||.
Zfish   389 AHDHPHIKTLEEVVETIKPTAIIGVAAIGGAFTEKIIKNMAANNERPIIFALSNPTSKAECTAEQ 453

  Fly   460 AYKHTDARVIFSSGSPFPPVQIGD-KTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQE 523
            .|..|:.|.||:|||||..|.:.| ::||||||||||:||||.||||..|..||.|::||..|:.
Zfish   454 CYTLTEGRGIFASGSPFKKVTLADGRSFYPGQGNNAYVFPGVALGVIACGVRHISDDIFLTTAEA 518

  Fly   524 LANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNY 588
            ::..|....:..|.|||||.:||.||..|||.:...||.:|:||.||||:||..::.:.:||.:|
Zfish   519 ISEMVTEEHLAEGRLYPPLKTIREVSFKIAVKIVDHAYKQGIASWYPEPKDKEAFILSHVYNSDY 583

  Fly   589 ESSMPASWVWPR 600
            :|....|:.||:
Zfish   584 DSFTLDSYSWPK 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	310/539 (58%)
		malic	117..298	CDD:278802	121/180 (67%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	144/277 (52%)
me3	NP_001082825.1	PLN03129	47..587	CDD:215594	311/556 (56%)
		malic	113..294	CDD:278802	121/180 (67%)
		NAD_bind_1_malic_enz	304..580	CDD:133454	144/277 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595262
Domainoid	1	1.000	270	1.000	Domainoid score	I1786
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100773
Inparanoid	1	1.050	641	1.000	Inparanoid score	I796
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm6390
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800