DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and ME2

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_002387.1	Gene:	ME2 / 4200	HGNCID:	6984	Length:	584	Species:	Homo sapiens

Alignment Length:	577	Identity:	302/577 - (52%)
Similarity:	410/577 - (71%)	Gaps:	15/577 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VAAATVPTARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEE 91
            |:.......||.|         .:.:|...:.:||.|||:||||:|||.||:.||.|.:.:||:.
Human     8 VSTTCTLACRHLH---------IKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDI 63

  Fly    92 QLQLCKIAVNRYTEPLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYR 156
            |.......:.:.|.||.||:|:..:.:|||:||:|.|.::||.||||||||||||||.::|.|:|
Human    64 QALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFR 128

  Fly   157 RPHGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGI 221
            ||.||||:.:||||:..::.||||.:|:|:.||||||||||||||..|||||||||.||||.|||
Human   129 RPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGI 193

  Fly   222 KPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFG 286
            :|.:|||:.:||||:||.||:||.|:||.|||...::||:.|||||:|:..|||:||||||||||
Human   194 RPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFG 258

  Fly   287 NHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLT 351
            ||||||||.|||..||||||||||||:||:|||.|::::..|...::..||.||||||:|||:|.
Human   259 NHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLI 323

  Fly   352 VKAMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHK---IHYAKDINPMSDLAEIVSTIKP 413
            |.:||::|:..:||..:|:|.|..|||.|.|| ..:|.::   .|.|.:..| ....:.|:.:||
Human   324 VMSMVENGLSEQEAQKKIWMFDKYGLLVKGRK-AKIDSYQEPFTHSAPESIP-DTFEDAVNILKP 386

  Fly   414 SVLIGASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPP 478
            |.:||.:.|..:|||:::|.||..|||||:|||||||::||||||:||..|:.|.:|:|||||.|
Human   387 STIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGP 451

  Fly   479 VQIGD-KTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPL 542
            |::.| :.|.||||||.||||||.|.||...|.||.|.:||.||:.|.:.:...::.:|.|||||
Human   452 VKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPL 516

  Fly   543 SSIRNVSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            ::|:.||:|||:.||:..|...:|..||||:||.|:::.:.:...|:|.:|..:.||
Human   517 ANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWP 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	294/542 (54%)
		malic	117..298	CDD:278802	122/180 (68%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	135/280 (48%)
ME2	NP_002387.1	PLN03129	28..566	CDD:215594	294/539 (55%)
		malic	89..270	CDD:278802	122/180 (68%)
		NAD_bind_1_malic_enz	280..558	CDD:133454	135/279 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159163
Domainoid	1	1.000	269	1.000	Domainoid score	I1852
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.650