DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Men-b and ME1

DIOPT Version :9

Sequence 1:NP_001163750.1 Gene:Men-b / 43936 FlyBaseID:FBgn0029155 Length:624 Species:Drosophila melanogaster
Sequence 2:NP_002386.1 Gene:ME1 / 4199 HGNCID:6983 Length:572 Species:Homo sapiens


Alignment Length:572 Identity:318/572 - (55%)
Similarity:401/572 - (70%) Gaps:22/572 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 PTARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCK 97
            |..||.|:           ||....|:|.|||.|||||||||.|.||||.|..|.:||  :|:.:
Human     6 PRRRHTHQ-----------RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQE--IQVLR 57

  Fly    98 IAVNRYTEPLN----KYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRP 158
            :..|  .|.||    :||.|.||.||||:||:|.|:.:||..||||||||||||||::.|::|:|
Human    58 VVKN--FEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP 120

  Fly   159 HGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKP 223
            .|||||.:|||||..|:..|||..::||.||||||||||||||..||||||||||||||..|:.|
Human   121 RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNP 185

  Fly   224 HQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNH 288
            .:|||:::||||.|.:||:||||:||||:||.|.|||:|:|||||||..:||.|.|||||||.|.
Human   186 QECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANV 250

  Fly   289 NAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVK 353
            ||||.|:||||.|||||||||||||||||||.|:.|||.....|.|.||.||||||:|||.|.|.
Human   251 NAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVM 315

  Fly   354 AMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIG 418
            |:.::|:|.|:|..:|::||..||:.|.|  .:|...|..:|.:...|.:|..||..|||:.|||
Human   316 ALEKEGLPKEKAIKKIWLVDSKGLIVKGR--ASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIG 378

  Fly   419 ASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQI-G 482
            .:|..|.|:.:||:.||..||||::||||||||||||:||..||.|..|.||:|||||.||.: .
Human   379 VAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPN 443

  Fly   483 DKTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRN 547
            .:|.|||||||:|:||||.|||:..|...|.|.:||..|:.:|..|....:|.|.|||||::||:
Human   444 GQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRD 508

  Fly   548 VSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            ||:.||..:.|.||....|:.|||||:|..::.:|:|:.:|:..:|..:.||
Human   509 VSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWP 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Men-bNP_001163750.1 PLN03129 51..590 CDD:215594 311/543 (57%)
malic 117..298 CDD:278802 122/180 (68%)
NAD_bind_1_malic_enz 308..585 CDD:133454 142/277 (51%)
ME1NP_002386.1 PLN03129 11..551 CDD:215594 312/556 (56%)
malic 79..260 CDD:278802 122/180 (68%)
NAD_bind_1_malic_enz 270..547 CDD:133454 143/278 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159168
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0281
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S996
OMA 1 1.010 - - QHG60768
OrthoDB 1 1.010 - - D334471at33208
OrthoFinder 1 1.000 - - FOG0000475
OrthoInspector 1 1.000 - - mtm8644
orthoMCL 1 0.900 - - OOG6_100205
Panther 1 1.100 - - LDO PTHR23406
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2182
SonicParanoid 1 1.000 - - X340
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.700

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