Protein Alignment Men-b and ME1

DIOPT Version :10

• Sequence 1: NP_001163750.1
• Gene: Men-b / 43936
• FlyBaseID: FBgn0029155
• Length: 624
• Species: Drosophila melanogaster
• Sequence 2: NP_002386.1
• Gene: ME1 / 4199
• HGNCID: 6983
• Length: 572
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 318/572 - (55%)
• Similarity: 401/572 - (70%)
• Gaps: 22/572 - (3%)

  Fly    33 PTARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCK 97
            |..||.|:           ||....|:|.|||.|||||||||.|.||||.|..|.:||  :|:.:
Human     6 PRRRHTHQ-----------RGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQE--IQVLR 57

  Fly    98 IAVNRYTEPLN----KYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRP 158
            :..|  .|.||    :||.|.||.||||:||:|.|:.:||..||||||||||||||::.|::|:|
Human    58 VVKN--FEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKP 120

  Fly   159 HGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKP 223
            .|||||.:|||||..|:..|||..::||.||||||||||||||..||||||||||||||..|:.|
Human   121 RGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNP 185

  Fly   224 HQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNH 288
            .:|||:::||||.|.:||:||||:||||:||.|.|||:|:|||||||..:||.|.|||||||.|.
Human   186 QECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANV 250

  Fly   289 NAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVK 353
            ||||.|:||||.|||||||||||||||||||.|:.|||.....|.|.||.||||||:|||.|.|.
Human   251 NAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVM 315

  Fly   354 AMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIG 418
            |:.::|:|.|:|..:|::||..||:.|.|  .:|...|..:|.:...|.:|..||..|||:.|||
Human   316 ALEKEGLPKEKAIKKIWLVDSKGLIVKGR--ASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIG 378

  Fly   419 ASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQI-G 482
            .:|..|.|:.:||:.||..||||::||||||||||||:||..||.|..|.||:|||||.||.: .
Human   379 VAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPN 443

  Fly   483 DKTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRN 547
            .:|.|||||||:|:||||.|||:..|...|.|.:||..|:.:|..|....:|.|.|||||::||:
Human   444 GQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRD 508

  Fly   548 VSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            ||:.||..:.|.||....|:.|||||:|..::.:|:|:.:|:..:|..:.||
Human   509 VSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWP 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	311/543 (57%)
ME1	NP_002386.1	PLN03129	11..551	CDD:215594	312/556 (56%)