DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and Me2

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	XP_006254985.1	Gene:	Me2 / 307270	RGDID:	1310321	Length:	591	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	298/577 - (51%)
Similarity:	406/577 - (70%)	Gaps:	16/577 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AATVP---TARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQE 90
            |.|.|   |.|..|         .:.:|...:.:||.|||:||||:|||.||:.||.|.:.:||:
  Rat    14 AVTTPCTLTCRRVH---------LKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQD 69

  Fly    91 EQLQLCKIAVNRYTEPLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIY 155
            .|.......:.:.|.||.||:|:..:.:|||:||:|.|.::||.||||||||||||||.::|.|:
  Rat    70 IQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIF 134

  Fly   156 RRPHGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAG 220
            |||.||||:.:||||:..::.||||.:|:|:.||||||||||||||..|||||||||.||||.||
  Rat   135 RRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAG 199

  Fly   221 IKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDF 285
            |:|.:|||:.:||||:|:.||:||.|:||.|||...:.||:.:||||:|:..|||:|||||||||
  Rat   200 IQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDF 264

  Fly   286 GNHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADL 350
            |||||||||.||:..||||||||||||:||::||.|::|:..|...::..||.||||||:|||.|
  Rat   265 GNHNAFRFLKKYQEKYCTFNDDIQGTAAVALSGLLAAQRVINKPISEHRILFLGAGEAALGIAKL 329

  Fly   351 TVKAMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHY--AKDINPMSDLAEIVSTIKP 413
            .|.:|::.|:..|||..:|:|.|.:|||.|.| ...:|.::..|  |...|..:...:.|:.:||
  Rat   330 IVISMMESGLSEEEAQRKIWMFDKNGLLVKGR-TARIDSNQEPYAHAASENIPATFEDAVNKLKP 393

  Fly   414 SVLIGASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPP 478
            ||:||.:.|..:|||.:::.||..||||::|||||||::|||||||||..|:.|.:|:|||||.|
  Rat   394 SVIIGVAGAGPLFTPGVIKAMAAINERPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFEP 458

  Fly   479 VQIGD-KTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPL 542
            |::.| :.|.|||||||||||||.|.||.....||.|.:||.||:.|.:.:...::.:|.|||.|
  Rat   459 VRLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTSQLTDEELAQGRLYPSL 523

  Fly   543 SSIRNVSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            ::|:.||.|||:.:.:..|...:|..||||:||.|:::.:::..||.|.:|..:.||
  Rat   524 ANIQEVSANIAIKIAEYLYANKMAFRYPEPEDKAKYVKERIWRSNYVSLLPDVYDWP 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	288/541 (53%)
		malic	117..298	CDD:278802	120/180 (67%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	131/279 (47%)
Me2	XP_006254985.1	PLN03129	35..573	CDD:215594	288/538 (54%)
		malic	96..277	CDD:278802	120/180 (67%)
		NAD_bind_1_malic_enz	287..565	CDD:133454	131/278 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353171
Domainoid	1	1.000	42	1.000	Domainoid score	I12101
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9123
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.620