DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and mae2

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_587760.1	Gene:	mae2 / 2539592	PomBaseID:	SPCC794.12c	Length:	565	Species:	Schizosaccharomyces pombe

Alignment Length:	561	Identity:	201/561 - (35%)
Similarity:	307/561 - (54%)	Gaps:	23/561 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRY----TE 105
            |.||  ::|:..:..||.||..|||.||||...|....|...:|.::|:..|   .::|    .|
pombe     9 IECP--LKGVTLLNSPRYNKDTAFTPEERQKFEISSRLPPIVETLQQQVDRC---YDQYKAIGDE 68

  Fly   106 PLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLF--ITYNDR 168
            ||.|.||||.|...|:.||:..:|:::.:::||:||||.|.|.::|..|||.|.|.:  |.:||.
pombe    69 PLQKNLYLSQLSVTNQTLFYALISQHLIEMIPIIYTPTEGDAIKQFSDIYRYPEGCYLDIDHNDL 133

  Fly   169 GHIFDVMKNW-PEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVD 232
            .:|...:..: ...:|..|.:||.|.|||:||.|..|:.|.|.|..|.|..||:.|::.||||:|
pombe   134 SYIKQQLSEFGKSDSVEYIIITDSEGILGIGDQGVGGVLISVAKGHLMTLCAGLDPNRFLPIVLD 198

  Fly   233 VGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKY 297
            |||||....::..|:|||:.||.|.:||.|:|..::|:.:.:.: ..|.|||||..||.|.||.|
pombe   199 VGTNNETHRKNHQYMGLRKDRVRGEQYDSFLDNVIKAIREVFPE-AFIHFEDFGLANAKRILDHY 262

  Fly   298 RNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPI 362
            |.....||||||||.:||:|.:..:..:|.....:...:..|||.|.:|||:..|..||.||:.:
pombe   263 RPDIACFNDDIQGTGAVALAAIIGALHVTKSPLTEQRIMIFGAGTAGVGIANQIVAGMVTDGLSL 327

  Fly   363 EEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYAKDIN----PMSD--LAEIVSTIKPSVLIGASA 421
            ::|...::|:|..|||.:.......||.|....||.:    |..|  |...::.:||::|:|.|.
pombe   328 DKARGNLFMIDRCGLLLERHAKIATDGQKPFLKKDSDFKEVPSGDINLESAIALVKPTILLGCSG 392

  Fly   422 AAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGDKTF 486
            ..|.||.:.:|.|:.:.|||::|.:||||:..|...:...|.:|.:.:.::|||.||:....|.:
pombe   393 QPGKFTEKAIREMSKHVERPIIFPISNPTTLMEAKPDQIDKWSDGKALIATGSPLPPLNRNGKKY 457

  Fly   487 YPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMN 551
            ...|.|||.::|.:|:..:.:....:.|.|...|:..||...........:|.|.|::.|.:|.:
pombe   458 VISQCNNALLYPALGVACVLSRCKLLSDGMLKAASDALATVPRSLFAADEALLPDLNNAREISRH 522

  Fly   552 IAVGVTKCAYDRGLASTYPEPQDKRK---WLENQLYNFNYE 589
            |...|.|.|...|: ||...|:|..|   |:..:.:|..|:
pombe   523 IVFAVLKQAVSEGM-STVDLPKDDAKLKEWIIEREWNPEYK 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	198/555 (36%)
		malic	117..298	CDD:278802	75/183 (41%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	88/285 (31%)
mae2	NP_587760.1	PRK13529	1..565	CDD:237414	201/561 (36%)
		malic	82..263	CDD:278802	75/181 (41%)
		NAD_bind_1_malic_enz	273..559	CDD:133454	88/286 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	147	1.000	Domainoid score	I1122
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I521
OMA	1	1.010	-	-		QHG60768
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9297
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
TreeFam	1	0.960	-	-
	11	10.760