DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and Me1

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_036732.3	Gene:	Me1 / 24552	RGDID:	3074	Length:	572	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	316/570 - (55%)
Similarity:	396/570 - (69%)	Gaps:	18/570 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PTARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCK 97
            |..||.|:           ||....|||.|||.|||||||||.|.||||.|.....||  :|:.:
  Rat     6 PRRRHTHQ-----------RGYLLTRDPHLNKDLAFTLEERQQLNIHGLLPPCIVNQE--IQVLR 57

  Fly    98 IAVN--RYTEPLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHG 160
            :..|  |.....::||.|.||.||||:||:..|..|:|..||||||||||||||::.|.:|:|.|
  Rat    58 VIKNFERLNSDFDRYLLLMDLQDRNEKLFYSVLMSNVEKFMPIVYTPTVGLACQQYSLAFRKPRG 122

  Fly   161 LFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQ 225
            |||:.:|:|||..|:..|||..|:||.||||||||||||||..||||||||||||||..|:.|.|
  Rat   123 LFISIHDKGHIASVLNAWPEDVVKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQQ 187

  Fly   226 CLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNA 290
            ||||.:||||.|.:||:||||:|||.:||.|.|||.|:||||||...:||.|.|||||||.|.||
  Rat   188 CLPITLDVGTENEELLKDPLYIGLRHRRVRGPEYDAFLDEFMEAASSKYGMNCLIQFEDFANLNA 252

  Fly   291 FRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAM 355
            ||.|:||||.|||||||||||||||||||.|:.|||.....|.|.||.||||||:|||.|.|.||
  Rat   253 FRLLNKYRNKYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTVLFQGAGEAALGIAHLIVMAM 317

  Fly   356 VQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGAS 420
            .::|:..|:|..:|::||..||:.|.|  .:|...|..:|.:...|.:|..||..|||:.|||.:
  Rat   318 EKEGLSKEKARQKIWLVDSKGLIVKGR--ASLTEEKEVFAHEHEEMKNLEAIVQKIKPTALIGVA 380

  Fly   421 AAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGD-K 484
            |..|.||.:||:.||..||||::||||||||||||:||:.||.|..|.||:|||||.||.:.| :
  Rat   381 AIGGAFTEQILKDMAAFNERPIIFALSNPTSKAECSAEECYKVTKGRAIFASGSPFDPVTLPDGR 445

  Fly   485 TFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVS 549
            |.:||||||:|:||||.|||:..|..||.|.:||..|:.::..|....:|.|.|||||::||:||
  Rat   446 TLFPGQGNNSYVFPGVALGVVACGLRHINDSVFLTTAEVISQQVSDKHLEEGRLYPPLNTIRDVS 510

  Fly   550 MNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            :.|||.:.:.||...:|:.|||||:|.:::.:|:|:.||:..:|..:.||
  Rat   511 LKIAVKIVQDAYKEKMATVYPEPQNKEEFVSSQMYSTNYDQILPDCYSWP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	309/541 (57%)
		malic	117..298	CDD:278802	120/180 (67%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	143/277 (52%)
Me1	NP_036732.3	PLN03129	11..551	CDD:215594	310/554 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353176
Domainoid	1	1.000	267	1.000	Domainoid score	I1794
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm9123
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	LDO	PTHR23406
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.720