DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and men-1

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_496968.1	Gene:	men-1 / 175079	WormBaseID:	WBGene00012983	Length:	620	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	296/553 - (53%)
Similarity:	387/553 - (69%)	Gaps:	4/553 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTEPLNKYLYLS 114
            |.||||.::.|.||||:||:|.|||.||:|||.|..|.|:|:|.......:.:..:.|.||:.|.
Worm    48 QKRGIDLLKSPGLNKGMAFSLHERQYLGVHGLLPPAFMTEEQQAYRIITKLRQQPDNLAKYIQLD 112

  Fly   115 DLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDR--GHIFDVMKN 177
            .|.||||:|::|.|.:|:::|||||||||||.|||.||.|||.|.||:||.||.  ..|..::.|
Worm   113 SLQDRNEKLYYRVLCDNVKELMPIVYTPTVGQACQHFGFIYRNPKGLYITINDNSISKIHQILAN 177

  Fly   178 WPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNIDLLE 242
            ||..|||||.:|||||||||||||..|:||||||||||.|||||:|..|||:::||||:|.:||.
Worm   178 WPTENVRAIVITDGERILGLGDLGTYGIGIPVGKLALYVALAGIRPEWCLPVILDVGTDNSELLN 242

  Fly   243 DPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCTFNDD 307
            ||.|.|||:|||.|.|||..:|.||:|..:|:|::||||||||||.||:|.||:|:..||.||||
Worm   243 DPFYTGLRRKRVRGPEYDTLVDNFMKAATKRFGRDTLIQFEDFGNQNAYRLLDRYKGEYCMFNDD 307

  Fly   308 IQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNRIYMV 372
            |||||:|.||||.||.|||.|.......:|.|||.||.|:|::.|:.|:.:|:..|||..|||||
Worm   308 IQGTAAVVVAGLLASTRITKKKLSQERIVFLGAGGAATGVAEMCVRQMMDEGLSEEEACGRIYMV 372

  Fly   373 DIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRTMADN 437
            ||:||:|.||. .:|....:.:|||:....:|.|:|.|:||..|||||..||.||.:|::.||..
Worm   373 DIEGLITTSRS-KSLGERHVKFAKDLPDTKNLLEVVKTVKPGALIGASTVAGAFTEDIIKEMARL 436

  Fly   438 NERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGDKTFYPGQGNNAYIFPGVGL 502
            |.||::|||||||||||||||.||:.|:..|:|:|||||..|::..|.:.|||||||||||||.|
Worm   437 NPRPIIFALSNPTSKAECTAETAYRCTNGAVLFASGSPFENVEMNGKLYKPGQGNNAYIFPGVAL 501

  Fly   503 GVICTGTHHIPDEMFLIAAQELANFVEPSDIERGS-LYPPLSSIRNVSMNIAVGVTKCAYDRGLA 566
            |.:...|.:|||::||:||:.:|..|....:...| :||.|..||.:|:.|||.|.:..|...||
Worm   502 GAVLFRTKNIPDKLFLLAARMVAEAVSEKSLNTYSRVYPRLKDIRELSVKIAVEVGEYCYRHDLA 566

  Fly   567 STYPEPQDKRKWLENQLYNFNYESSMPASWVWP 599
            :.:|:|.|...::...||:..|:..:..::.||
Worm   567 TLHPKPDDMEMFIRQNLYSVEYDELINKTYEWP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	293/541 (54%)
		malic	117..298	CDD:278802	117/182 (64%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	137/277 (49%)
men-1	NP_496968.1	PLN03129	46..592	CDD:215594	294/544 (54%)
		malic	115..298	CDD:278802	117/182 (64%)
		Malic_M	308..560	CDD:281882	130/252 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166737
Domainoid	1	1.000	256	1.000	Domainoid score	I1094
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100773
Inparanoid	1	1.050	596	1.000	Inparanoid score	I524
Isobase	1	0.950	-	0	Normalized mean entropy	S996
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		otm14554
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	LDO	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790