DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Men-b and Me3

DIOPT Version :9

Sequence 1:	NP_001163750.1	Gene:	Men-b / 43936	FlyBaseID:	FBgn0029155	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_852072.2	Gene:	Me3 / 109264	MGIID:	1916679	Length:	604	Species:	Mus musculus

Alignment Length:	558	Identity:	316/558 - (56%)
Similarity:	408/558 - (73%)	Gaps:	11/558 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTE----PLN 108
            |.:.||.|..|:|.||||:|||||||..||||||.|..|.:|:.||    :.:.||.|    .|:
Mouse    45 PLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQL----LRIMRYYENQQSDLD 105

  Fly   109 KYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFD 173
            ||:.|..|.||||:||:|.|:.::|..||||||||||||||.:||.:|||.|||||.:|:|||..
Mouse   106 KYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHIAT 170

  Fly   174 VMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNI 238
            ::.:|||.|::|:.||||||||||||||..||||||||||||||..|:.|.||||:::||||||.
Mouse   171 MLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNE 235

  Fly   239 DLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCT 303
            :||.||||:||:.:||.|.|||:.:||||:||..::|.|.|||||||.|.||||.|:||||.||.
Mouse   236 ELLRDPLYIGLKHQRVRGEEYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM 300

  Fly   304 FNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNR 368
            |||||||||||||||:.|:.|||.....::.|:|.||||||:|||.|.|.|:.::|:|..||..:
Mouse   301 FNDDIQGTASVAVAGILAALRITKNRLSNHVFVFQGAGEAAMGIAHLLVMALEKEGIPKTEAIKK 365

  Fly   369 IYMVDIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRT 433
            |:|||..||:.|.|  .:|:..|..:|:|...::.|.|:|..:||:.:||.:|.||.||.:|||.
Mouse   366 IWMVDSKGLIVKGR--SHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRD 428

  Fly   434 MADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGD-KTFYPGQGNNAYIF 497
            ||..:|||:||||||||||||||||..|:.|:.|.||:|||||..|.:.| :||.||||||||:|
Mouse   429 MASFHERPIVFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGRTFTPGQGNNAYVF 493

  Fly   498 PGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYD 562
            |||.||||..|..|||||:||:.|:::|..|....:.:|.||||||:||:||:.|||.|...||.
Mouse   494 PGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAVKVLDYAYK 558

  Fly   563 RGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWPR 600
            ..|||.||||:||..::::.:|..:|:|....::.||:
Mouse   559 HNLASYYPEPKDKEAFVKSLIYTPDYDSFSLDTYSWPK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	312/543 (57%)
		malic	117..298	CDD:278802	118/180 (66%)
		NAD_bind_1_malic_enz	308..585	CDD:133454	148/277 (53%)
Me3	NP_852072.2	PLN03129	9..587	CDD:215594	313/547 (57%)
Me3	NP_852072.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..50		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849533
Domainoid	1	1.000	269	1.000	Domainoid score	I1830
eggNOG	1	0.900	-	-		E1_COG0281
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100773
Inparanoid	1	1.050	629	1.000	Inparanoid score	I848
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60768
OrthoDB	1	1.010	-	-		D334471at33208
OrthoFinder	1	1.000	-	-		FOG0000475
OrthoInspector	1	1.000	-	-		mtm8876
orthoMCL	1	0.900	-	-		OOG6_100205
Panther	1	1.100	-	-	O	PTHR23406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2182
SonicParanoid	1	1.000	-	-		X340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800