Protein Alignment Men-b and ME3

DIOPT Version :10

• Sequence 1: NP_001163750.1
• Gene: Men-b / 43936
• FlyBaseID: FBgn0029155
• Length: 624
• Species: Drosophila melanogaster
• Sequence 2: NP_006671.2
• Gene: ME3 / 10873
• HGNCID: 6985
• Length: 604
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 315/558 - (56%)
• Similarity: 407/558 - (72%)
• Gaps: 11/558 - (1%)

  Fly    48 PSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQEEQLQLCKIAVNRYTE----PLN 108
            |.:.||.|..|:|.||||:|||||||..||||||.|..|.:|:.||    :.:.||.|    .|:
Human    45 PLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQL----LRIMRYYERQQSDLD 105

  Fly   109 KYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIYRRPHGLFITYNDRGHIFD 173
            ||:.|..|.||||:||:|.|:.::|..||||||||||||||.:||.:|||.|||||.:|:||:..
Human   106 KYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLAT 170

  Fly   174 VMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHQCLPIVVDVGTNNI 238
            ::.:|||.|::|:.||||||||||||||..||||||||||||||..|:.|.||||:::||||||.
Human   171 MLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNE 235

  Fly   239 DLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDFGNHNAFRFLDKYRNTYCT 303
            :||.||||:||:.:||.|:.||:.:||||:||..::|.|.|||||||.|.||||.|:||||.||.
Human   236 ELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCM 300

  Fly   304 FNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADLTVKAMVQDGVPIEEAYNR 368
            |||||||||||||||:.|:.|||.....::.|:|.||||||:|||.|.|.|:.::|||..||..:
Human   301 FNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRK 365

  Fly   369 IYMVDIDGLLTKSRKVGNLDGHKIHYAKDINPMSDLAEIVSTIKPSVLIGASAAAGIFTPEILRT 433
            |:|||..||:.|.|  .:|:..|..:|:|...::.|.|:|..:||:.:||.:|.||.||.:|||.
Human   366 IWMVDSKGLIVKGR--SHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRD 428

  Fly   434 MADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFPPVQIGD-KTFYPGQGNNAYIF 497
            ||..:|||::|||||||||||||||..|:.|:.|.||:|||||..|.:.| |||.||||||||:|
Human   429 MASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVF 493

  Fly   498 PGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPPLSSIRNVSMNIAVGVTKCAYD 562
            |||.||||..|..|||||:||:.|:::|..|....:.:|.||||||:||:||:.||:.|...||.
Human   494 PGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYK 558

  Fly   563 RGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWPR 600
            ..|||.||||:||..::.:.:|..:|:|....|:.||:
Human   559 HNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPK 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	310/543 (57%)
ME3	NP_006671.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..50		1/4 (25%)
		PLN03129	38..588	CDD:215594	312/548 (57%)