Protein Alignment Men-b and Me2

DIOPT Version :10

• Sequence 1: NP_001163750.1
• Gene: Men-b / 43936
• FlyBaseID: FBgn0029155
• Length: 624
• Species: Drosophila melanogaster
• Sequence 2: XP_006525559.1
• Gene: Me2 / 107029
• MGIID: 2147351
• Length: 596
• Species: Mus musculus
• Alignment Length: 594
• Identity: 301/594 - (50%)
• Similarity: 412/594 - (69%)
• Gaps: 23/594 - (3%)

  Fly    29 AATVP---TARHYHEVVGDIICPSQVRGIDHIRDPRLNKGLAFTLEERQTLGIHGLQPARFKTQE 90
            |.|.|   |.|..|         .:.:|...:.:||.|||:||||:|||.||:.||.|.:.:||:
Mouse    14 AVTTPCTLTCRRVH---------LKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQD 69

  Fly    91 EQLQLCKIAVNRYTEPLNKYLYLSDLYDRNERLFFRFLSENIEDLMPIVYTPTVGLACQRFGLIY 155
            .|.......:.:.|.||.||:|:..:.:|||:||:|.|.::||.||||||||||||||.::|.|:
Mouse    70 IQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACCQYGHIF 134

  Fly   156 RRPHGLFITYNDRGHIFDVMKNWPEPNVRAICVTDGERILGLGDLGACGMGIPVGKLALYTALAG 220
            |||.||||:.:||||:..::.||||.:|:|:.||||||||||||||..|||||||||.||||.||
Mouse   135 RRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAG 199

  Fly   221 IKPHQCLPIVVDVGTNNIDLLEDPLYVGLRQKRVVGREYDEFIDEFMEAVVQRYGQNTLIQFEDF 285
            |:|.:|||:.:||||:|:.||:||.|:||.|||...:.||:.:||||:|:..|||:|||||||||
Mouse   200 IQPEKCLPVCIDVGTDNMALLKDPFYMGLYQKRDRSQLYDDLMDEFMKAITDRYGRNTLIQFEDF 264

  Fly   286 GNHNAFRFLDKYRNTYCTFNDDIQGTASVAVAGLYASKRITGKSFKDYTFLFAGAGEAAIGIADL 350
            |||||||||.||:..||||||||||||:||::||.|::|:..|...::..||.||||||:|||:|
Mouse   265 GNHNAFRFLRKYQQKYCTFNDDIQGTAAVALSGLLAAQRVINKPVSEHKILFLGAGEAALGIANL 329

  Fly   351 TVKAMVQDGVPIEEAYNRIYMVDIDGLLTKSRKVGNLDGHK---IHYAKDINPMSDLAEIVSTIK 412
            .|.:||:.|:..|||..:|:|.|..|||.|.| ..::|.::   .|.|.:..| :...:.|:.:|
Mouse   330 IVLSMVESGLSEEEAQRKIWMFDKSGLLVKGR-TASIDSNQEPYAHAAPESIP-ATFEDAVNKLK 392

  Fly   413 PSVLIGASAAAGIFTPEILRTMADNNERPVVFALSNPTSKAECTAEDAYKHTDARVIFSSGSPFP 477
            |||:||.:.|..:||..:::.||..||||::|||||||::|||||||||..|:.|.:|:|||||.
Mouse   393 PSVIIGVAGAGPLFTHGVIKAMASINERPIIFALSNPTAQAECTAEDAYTLTEGRCLFASGSPFE 457

  Fly   478 PVQIGD-KTFYPGQGNNAYIFPGVGLGVICTGTHHIPDEMFLIAAQELANFVEPSDIERGSLYPP 541
            ||::.| :.|.|||||||||||||.|.||.....||.|.:||.||:.|...:..:::.:|.|||.
Mouse   458 PVKLQDGRVFTPGQGNNAYIFPGVALAVILCEARHISDTVFLEAAKALTTQLTDAELAQGRLYPS 522

  Fly   542 LSSIRNVSMNIAVGVTKCAYDRGLASTYPEPQDKRKWLENQLYNFNYESSMPASWVWPRM----P 602
            |::|:.||.|||:.:.:..|...:|..||||:||.:::..:::..||.|.:|..:.||..    |
Mouse   523 LANIQEVSANIAIKLAEYLYANKMAFRYPEPEDKARYVRERIWRSNYVSLLPDVYDWPESSLTPP 587

  Fly   603 YIKTRDLVP 611
            .| |.:.:|
Mouse   588 QI-TEEKLP 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Men-b	NP_001163750.1	PLN03129	51..590	CDD:215594	287/542 (53%)
Me2	XP_006525559.1	PLN03129	35..573	CDD:215594	287/539 (53%)