DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and GLRA3

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_006520.2	Gene:	GLRA3 / 8001	HGNCID:	4328	Length:	464	Species:	Homo sapiens

Alignment Length:	305	Identity:	69/305 - (22%)
Similarity:	122/305 - (40%)	Gaps:	67/305 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 GYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHMMM 265
            ||.:.|.|               |.:....::..|:...||    .|:|  :|:...:..:.:..
Human    56 GYDARIRP---------------NFKGPPVNVTCNIFINSF----GSIA--ETTMDYRVNIFLRQ 99

  Fly   266 HWRDSRLVWK--PEDFGSLESFEHPDL--RIWKPHMNVLNGALQSMGQVLQSYELM-VYANGSIT 325
            .|.|.||.:.  |:|...|:    |.:  .||||.:...|....:..:|....:|: ::.||::
Human   100 KWNDPRLAYSEYPDDSLDLD----PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNV- 159

  Fly   326 LYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWS 390
            ||:..|.|...|....:|:|.:..||.::|...|....:   ||::.|.:  ||   |....|.:
Human   160 LYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMND---LIFEWQDE--AP---VQVAEGLT 216

  Fly   391 FTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLR 455
            ..|.   |::.:...||..|.........:.:.|.|:|...:|:...|:|
Human   217 LPQF---LLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIP--------------- 263

  Fly   456 STRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMTT 500
                 ||:::   |.:|...::...|:|..|...:|.  |:.|||
Human   264 -----SLLIV---ILSWVSFWINMDAAPARVALGITT--VLTMTT 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	49/221 (22%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	69/305 (23%)
GLRA3	NP_006520.2	Strychnine-binding. /evidence=ECO:0000269\|PubMed:26416729	235..240		0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910