DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Chrna10

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_006229953.1	Gene:	Chrna10 / 64574	RGDID:	620142	Length:	492	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	81/407 - (19%)
Similarity:	148/407 - (36%)	Gaps:	80/407 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 FDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHM 263
            |..|.|.:.|:...:            |..|.::...||.|        :..::.:.:|...:.:
  Rat    83 FANYTSALRPVADTD------------QTLNVTLEVTLSQI--------IDMDERNQVLTLYLWI 127

  Fly   264 MMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYA 328
            ...|.|:.|.|.|:.:|.|::...|...:|:|.:.:.|.| .:......|..::|..:|::...|
  Rat   128 RQEWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKA-DTQPPASASTNVVVRHDGAVRWDA 191

  Fly   329 QNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSFTQ 393
            ..:..:|..||.:. :|.:...|.:..|.....|.:.      |.|           |.|   |.
  Rat   192 PAITRSSCRVDVSA-FPFDAQRCGLTFGSWTHGGHQL------DVR-----------PRG---TS 235

  Fly   394 MSVV-LVEN--------DSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLI 449
            .|:. .|||        .::||....|...:...||.....|:|..:.|:....||.:...:...
  Rat   236 ASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAP 300

  Fly   450 LSFVL--RSTRRSSL-ILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYCYILHICII 511
            |:|.|  .|..:.|| :.:.|.:..:.|:..........||.:...|...|...|:...|.|.|:
  Rat   301 LAFHLPADSGEKVSLGVTVLLALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIM 365

  Fly   512 WLDLYPPRS-KAPGWLVRVINSNVLRCILGLRFSDSTDYCDIQE----------------NPWH- 558
            .|....|.: ..|.|...::..::.:   ||...:..:.|...:                .|.|
  Rat   366 NLHYCGPNAHPVPAWARVLLLGHLAK---GLCVRERGEPCGQSKPLESAPSLQPPPASPAGPCHE 427

  Fly   559 -----HMAKILNNLSSI 570
                 |...:|::::||
  Rat   428 PRCLCHQEALLHHIASI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	44/225 (20%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:273305	81/407 (20%)
		Neur_chan_LBD	77..280	CDD:280998	48/238 (20%)
		Neur_chan_memb	288..482	CDD:280999	31/160 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810