DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Htr3b

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_071525.1	Gene:	Htr3b / 58963	RGDID:	61820	Length:	437	Species:	Rattus norvegicus

Alignment Length:	270	Identity:	63/270 - (23%)
Similarity:	94/270 - (34%)	Gaps:	78/270 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 LQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYEL-MVYA 320
            |:|.|.....|.|..|.|....|..::....|...||.|.: ::|    ....|.:|.:| .||.
  Rat    74 LKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDI-IIN----EFVDVERSPDLPYVYV 133

  Fly   321 NGSITLYAQN-LQLASWCVDSARNWPSERVTC------------DIELG-LNGQEGQENVALIYD 371
            |.|.|:.... :|:.|.|......:|.:...|            ||:|| |..||..||
  Rat   134 NSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIEN------ 192

  Fly   372 DQRKPIAPNE----------HVNTPSGWSFTQM--------------------SVVLVENDSQRR 406
            |:|..:..:|          |:...|...|.|:                    |:.|:..|....
  Rat   193 DKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSF 257

  Fly   407 YNPKGMMQKMT--GDVAIEFTLQR-------NRSFYMT----VFYLPLIACQMFLILSFVLRSTR 458
            |.|.....::.  .:|.:.:|:.|       .||...|    ||:   ..|...|:||.
  Rat   258 YLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFF---TVCMALLVLSL------ 313

  Fly   459 RSSLILIALL 468
            ..|::||..|
  Rat   314 SKSILLIKFL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	50/225 (22%)
Htr3b	NP_071525.1	LIC	30..431	CDD:273305	63/270 (23%)
		Neur_chan_LBD	30..233	CDD:280998	42/169 (25%)
		Neur_chan_memb	242..>313	CDD:280999	16/73 (22%)
		HA-stretch	377..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900