Protein Alignment NtR and Htr3b

DIOPT Version :10

• Sequence 1: NP_651958.2
• Gene: NtR / 43935
• FlyBaseID: FBgn0029147
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_071525.1
• Gene: Htr3b / 58963
• RGDID: 61820
• Length: 437
• Species: Rattus norvegicus
• Alignment Length: 270
• Identity: 63/270 - (23%)
• Similarity: 94/270 - (34%)
• Gaps: 78/270 - (28%)

  Fly   257 LQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYEL-MVYA 320
            |:|.|.....|.|..|.|....|..::....|...||.|.: ::|    ....|.:|.:| .||.
  Rat    74 LKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDI-IIN----EFVDVERSPDLPYVYV 133

  Fly   321 NGSITLYAQN-LQLASWCVDSARNWPSERVTC------------DIELG-LNGQEGQENVALIYD 371
            |.|.|:.... :|:.|.|......:|.:...|            ||:|| |..||..||
  Rat   134 NSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIEN------ 192

  Fly   372 DQRKPIAPNE----------HVNTPSGWSFTQM--------------------SVVLVENDSQRR 406
            |:|..:..:|          |:...|...|.|:                    |:.|:..|....
  Rat   193 DKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSF 257

  Fly   407 YNPKGMMQKMT--GDVAIEFTLQR-------NRSFYMT----VFYLPLIACQMFLILSFVLRSTR 458
            |.|.....::.  .:|.:.:|:.|       .||...|    ||:   ..|...|:||.
  Rat   258 YLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFF---TVCMALLVLSL------ 313

  Fly   459 RSSLILIALL 468
            ..|::||..|
  Rat   314 SKSILLIKFL 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	89..191	CDD:463505
		Neur_chan_LBD	212..429	CDD:460752	50/225 (22%)
Htr3b	NP_071525.1	LGIC_ECD	25..233	CDD:475126	42/169 (25%)
		LGIC_TM_5-HT3	236..432	CDD:349865	21/97 (22%)
		TM1 helix	236..260	CDD:349865	4/23 (17%)
		TM2 helix	268..289	CDD:349865	3/20 (15%)
		TM3 helix	300..322	CDD:349865	9/30 (30%)
		HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:O95264	377..409
		TM4 helix	407..429	CDD:349865