DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NtR and Htr3b

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_064670.1	Gene:	Htr3b / 57014	MGIID:	1861899	Length:	437	Species:	Mus musculus

Alignment Length:	408	Identity:	77/408 - (18%)
Similarity:	132/408 - (32%)	Gaps:	110/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LLSHLNIQAENASMPANLSSISFHFQTRSLAY-------------EQTSSLLQTRMHMMMH---- 266
            |::.:.|.......|.|   .|.|..||.|..             |.|:..|...:|.::.
Mouse     9 LVAVVGILGTATPQPGN---SSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQ 70

  Fly   267 -------------WRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYEL-M 317
                         |.|..|.|....|..::....|...:|.|.: ::|    ....|.:|.:| .
Mouse    71 NQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDI-IIN----EFVDVERSPDLPY 130

  Fly   318 VYANGSITLYAQN-LQLASWCVDSARNWPSERVTC------------DIELG-LNGQEGQEN--V 366
            ||.|.|.|:.... :|:.|.|......:|.:...|            ||:|| |..:|..||  .
Mouse   131 VYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKR 195

  Fly   367 ALIYDD--QRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRN 429
            |.:.|.  |...::...|:...|...|.|:           |:|               ..::|.
Mouse   196 AFMNDSEWQLLSVSSTYHIRQSSAGDFAQI-----------RFN---------------VVIRRC 234

  Fly   430 RSFYMTVFYLPLIACQMFLILSFVLRSTRRSSLILIALLIAAWGLMYMTRYASPHYVP------P 488
            ...|:....:|.|...:..:.||.|....|:.::....::..:.:.   |......||      |
Mouse   235 PLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVF---RVNMSDEVPRSAGCTP 296

  Fly   489 MMTAYKVIMMTTTYCYILHICIIWLDLYPPRSKAPGWLVRVINSNVLRCILGLRFSDSTD----- 548
            ::..:..:.|......:....::...||..|...        ....|.|:.|  .||:.:
Mouse   297 LIGVFFTVCMALLVLSLSKSILLIKFLYEERHSG--------QERPLMCLQG--DSDAEESRLYL 351

  Fly   549 ---YCDIQENPWHHMAKI 563
               ..|:.|:|.|...::
Mouse   352 GAPRADVTESPVHQEHRV 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	52/258 (20%)
Htr3b	NP_064670.1	LIC	30..431	CDD:273305	71/384 (18%)
		Neur_chan_LBD	30..233	CDD:280998	46/233 (20%)
		Neur_chan_memb	242..>313	CDD:280999	11/73 (15%)
		HA-stretch	377..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900