DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and chrna10a

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_021337092.1	Gene:	chrna10a / 556507	ZFINID:	ZDB-GENE-060503-725	Length:	532	Species:	Danio rerio

Alignment Length:	354	Identity:	69/354 - (19%)
Similarity:	124/354 - (35%)	Gaps:	73/354 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 FDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHM 263
            |:.|.|.:.|:    ..||.:|        |.::...||.|        :..::.:.:|...:.:
Zfish    38 FNNYTSALRPV----EDTEDIL--------NVTLQITLSQI--------IDMDERNQILTAYLWI 82

  Fly   264 MMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYA 328
            ...|.|..|.|..|::..|::...|...:|:|.:.:.|.|.......:.: .:::..:|.|...|
Zfish    83 RQVWIDKYLTWNKENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDT-NVVIRHDGQIMWDA 146

  Fly   329 QNLQLASWCVDSARNWPSERVTCDIELG-----------LNGQEGQENVALIYDDQRKPIAPNEH 382
            ..:..:|..|| ...:|.:...|.:..|           ||..|..:...|:           ::
Zfish   147 PAITKSSCKVD-VSFFPFDAQQCRLTYGSWTYNGNQLDILNAMESADLADLV-----------DN 199

  Fly   383 VNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMF 447
            |.    |....|       .::|.....|.......||.....|:|..|||:....:|.:.....
Zfish   200 VE----WEVLGM-------PAKRNIILYGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFL 253

  Fly   448 LILSFVL--RSTRRSSL-ILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMT--------TT 501
            ..|.|.|  .|..:.|| :.:.|.:..:.|: :.....|....|::..|.:..||        |.
Zfish   254 APLGFYLPADSGEKVSLGVTVMLALTVFQLL-VAEIMPPSENVPLIGKYYIATMTMITASTALTI 317

  Fly   502 YCYILHICIIWLDLYPPRSKAPGWLVRVI 530
            :...:|.|      .|.....|.|..:.|
Zfish   318 FVMNIHHC------GPDAKPVPDWAKKFI 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	40/227 (18%)
chrna10a	XP_021337092.1	Neur_chan_LBD	31..422	CDD:332142	69/354 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900