DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-28

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001022053.1	Gene:	lgc-28 / 3565225	WormBaseID:	WBGene00044301	Length:	397	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	71/355 - (20%)
Similarity:	116/355 - (32%)	Gaps:	135/355 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESF---EHPDLR--IWKPHM---NVLNGA---- 303
            :....:|:..:.....|.|.||:|.|.::..:.:|   .|...|  .|.|.:   :|.|..
Worm    71 QDEQGVLKMALTFTFTWMDERLMWNPSNYSGIRTFSTTRHEMWRKKFWTPTLMMTDVPNSRRPSD 135

  Fly   304 ----------LQSMGQVLQSYELMV--------------YANGSITL----YAQNLQLASW-CVD 339
                      :.|.|.|..|..:|:              |.|.:.||    ||...:.|.| ..:
Worm   136 VFKPFDMDIYISSSGMVRTSARMMLTIPCRTGFGSYPNDYKNCTFTLMSPYYADQFRFAQWGGAE 200

  Fly   340 SARNWPSERVTCDIELGLNGQE--------GQENVALIYDD--QRKPIAPNEHVNTPSGWSFTQM 394
            ..|...|.|||..::..|...:        |.|    :.||  :.||    .|..     ||.:.
Worm   201 FTRYLMSSRVTDVLDFQLINIDTRNYYMFLGSE----VVDDFSKFKP----RHCR-----SFYRY 252

  Fly   395 SVVLVENDSQRRYNP-------------------KGMMQKMTGDVAIEFTLQRNRSFYMTVFY-- 438
            ::||      :|.|.                   .|.:....|.|.....|     .|.|:|.
Worm   253 NLVL------KRVNKFVSVQLIAPISVIAVFLAISGFLPHFYGLVCAGSAL-----VYETIFTYD 306

  Fly   439 -----------LPLIACQMFLILSFVLRSTRRSSLILIALLIAAWGLMYM-TR-----YASPHYV 486
                       :|:||    ::|.|:...|         :::.||.:..: ||     .|.|.|.
Worm   307 VEQVLPKDYSGMPMIA----ILLCFLFAET---------IVLLAWKVFSINTRSHTVFTAFPEYF 358

  Fly   487 PPMMTAYKVIMMTTTYCYILHICIIWLDLY 516
            ...:|:.|..::.         .:||:|.:
Worm   359 DDEITSKKEKLLK---------FVIWVDKF 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	50/247 (20%)
lgc-28	NP_001022053.1	LGIC_ECD	62..>187	CDD:355788	23/115 (20%)
		LIC	67..>329	CDD:273305	58/285 (20%)
		Cys-loop	164..178	CDD:349787	1/13 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900