DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and nAChRalpha6

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	81/391 - (20%)
Similarity:	141/391 - (36%)	Gaps:	86/391 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 IVKEETK---TEKLLSHLNIQAENASMP-ANLS---SISFHFQTRSLA-YEQTSSLLQTRMHMMM 265
            |:||..:   .::||:||.........| ||.|   .:.|....:.:. .::.:.:|.|...:.:
  Fly    20 IIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNL 84

  Fly   266 HWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYAQN 330
            .|.|..|.|...::|.::.......::|||.:.:.|.|.:.......: .::|..||| .||...
  Fly    85 EWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHT-NIVVKHNGS-CLYVPP 147

  Fly   331 LQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSF--TQ 393
            ....|.|......:|.:...|:::.|                               .|::  .|
  Fly   148 GIFKSTCKIDITWFPFDDQHCEMKFG-------------------------------SWTYDGNQ 181

  Fly   394 MSVVLVEND----SQRRYNPKGMMQKMTGD-------------VAIEFTLQ--RNRSFYMTVFYL 439
            :.:||...|    |....|.:..:..|.|.             |.|.||:|  |...:|.....:
  Fly   182 LDLVLNSEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIV 246

  Fly   440 PLIACQMFLILSFVLRSTRRSSLIL-IALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYC 503
            |.:......:|.|.|.......|.| :.:|::.  .:::...|..  :|....|..:|.:|
  Fly   247 PCVLISSMALLGFTLPPDSGEKLTLGVTILLSL--TVFLNLVAES--MPTTSDAVPLIGVT---- 303

  Fly   504 YILHICIIWLDL----YPPRSKAPGWLVRVIN-------SNVLRCILGLRFSDSTDYCDIQE-NP 556
             ||....::|:|    .|..|.|...|....|       |:|:..::.|.:...|  .||.| .|
  Fly   304 -ILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRT--ADIHEMPP 365

  Fly   557 W 557
            |
  Fly   366 W 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	47/245 (19%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	81/391 (21%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	38/213 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100