DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and nAChRbeta3

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_525098.1	Gene:	nAChRbeta3 / 33228	FlyBaseID:	FBgn0031261	Length:	441	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	90/448 - (20%)
Similarity:	161/448 - (35%)	Gaps:	134/448 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 FDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSLLQTRMHM 263
            |..|.|::.|:.:                   ..|.|   :|.......:..::.:..|.|...:
  Fly    59 FTNYDSDVQPVFQ-------------------GTPTN---VSLEMVVTYIDIDELNGKLTTHCWL 101

  Fly   264 MMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLN---GALQSMGQVLQSYE-------LMV 318
            .:.|||...||:|..:.::.........:|.|.:.:.|   |.|.:..||..|::       ..|
  Fly   102 NLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGGLMAETQVTLSHDGHFRWMPPAV 166

  Fly   319 YANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGL---------NGQEGQENVALIYDDQR 374
            |              .::|..:..|||.::.:|.:::|.         ||....|  :|.:||.
  Fly   167 Y--------------TAYCELNMLNWPHDKQSCKLKIGSWGLKVVLPENGTARGE--SLDHDDL- 214

  Fly   375 KPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYL 439
                    |.:|. |...         ||:..:    :.|...|.:....|.||..|.|..|.|.
  Fly   215 --------VQSPE-WEIV---------DSRAHF----VSQDYYGYMEYTLTAQRRSSMYTAVIYT 257

  Fly   440 PLIACQMFLILS-FVLRSTRRSSLI----LIALLIAAWGLMYMTRYASPHYVPPMM---TAYKVI 496
            | .:|.:.|.|| |.|........|    |:.::|||: |||..:      :.|::   |...||
  Fly   258 P-ASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAF-LMYFAQ------LLPVLSNNTPLVVI 314

  Fly   497 MMTTTYCY-----ILHICIIWLDLYPPRSKAPGWLVRVINSNVLRCILGLRFS------------ 544
            ..:|:..|     |:.:.:::|.....:.:.|..|.::::.::...:|...||
  Fly   315 FYSTSLLYLSVSTIVEVLVLYLATGKHKRRLPEALRKLLHGHLGTWLLLSVFSTTGESQAEKTKE 379

  Fly   545 -DSTDY--CDIQEN------------------PWHHMAKILNNLSSILVIITFAIVDI 581
             |...|  .|.||:                  .|..:|..::.:|.:...:.|.|:.|
  Fly   380 MDEHPYEEADEQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFLILAI 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	42/235 (18%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:273305	89/446 (20%)
		Neur_chan_LBD	52..247	CDD:280998	46/248 (19%)
		Neur_chan_memb	255..434	CDD:280999	38/186 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910