DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Chrnb1

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001382047.1	Gene:	Chrnb1 / 24261	RGDID:	2349	Length:	504	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	82/368 - (22%)
Similarity:	142/368 - (38%)	Gaps:	45/368 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 GSEIAPIVKEETKTEKLLSHLNIQAENASMPA----NLSSISFHF---QTRSLAYE-QTSSLLQT 259
            |:.:||..:......:||..|....:::..||    :...:|...   |..||..| :....:.|
  Rat    14 GTPLAPGARGSEAEGQLLKKLFSDYDSSVRPAQEVGDRVGVSIGLTLAQLISLVRENEKDEEMST 78

  Fly   260 RMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSI 324
            ::::.:.|.|.||.|.|.:...:||.......:|.|.:.:||.. .....|.....::|...||:
  Rat    79 KVYLDLEWTDYRLSWDPAEHDGIESLRVTAESVWLPDVVLLNNN-DGNFDVALDINVVVSFEGSV 142

  Fly   325 T-----LYAQNLQLA------SW--C--VDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQR 374
            .     ||..:..:.      .|  |  |.|:.::.|..|:.......:|||.||    ||..:.
  Rat   143 RWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGPDPDGQERQE----IYIHEG 203

  Fly   375 KPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYL 439
            ..|...:       |........|:.....||...:|..:    :|.....::|...||:.....
  Rat   204 TFIENGQ-------WEIIHKPSRLIHLPGDRRGGKEGHRE----EVIFYLIIRRKPLFYLVNVIA 257

  Fly   440 PLIACQMFLILSFVL--RSTRRSSLILIALL-IAAWGLMYMTRYASPHYVPPMMTAYKVI-MMTT 500
            |.|...:..|..|.|  .:..:..|.:.||| :..:.|:...:........|::..|.:. |:..
  Rat   258 PCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMILV 322

  Fly   501 TYCYILHICIIWLDLYPPRS-KAPGWLVRVINSNVLRCILGLR 542
            |:..||.:.::.|....|.: :.|.| ||.|..:.|...|||:
  Rat   323 TFSVILSVVVLNLHHRSPHTHQMPFW-VRQIFIHKLPPYLGLK 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	49/239 (21%)
Chrnb1	NP_001382047.1	LGIC_ECD_nAChR_B1	27..248	CDD:349825	50/236 (21%)
		Neur_chan_memb	255..490	CDD:397193	27/111 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..384		82/368 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900