DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and acr-23

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_504024.2	Gene:	acr-23 / 191606	WormBaseID:	WBGene00000062	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	62/354 - (17%)
Similarity:	118/354 - (33%)	Gaps:	112/354 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 TRSLAYEQTSSLLQTRMHMMMH------WRDSRLVWKPEDFGSLESF--EHPDLRIWKPHMNVLN 301
            |.||...|...:.:.:.:::::      |.|..|.|.|.:|.:....  .|.|  ||.|...:.|
Worm    55 TLSLQLYQIIQVNEPQQYLLLNAWAVERWVDQMLGWDPSEFDNETEIMARHDD--IWLPDTTLYN 117

  Fly   302 G--------------ALQSMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCD 352
            .              .|.::|:...:...::|.    |:|..:      |:.:.:.:|.:..||.
Worm   118 SLEMDDSASKKLTHVKLTTLGKNQGAMVELLYP----TIYKIS------CLLNLKYFPFDTQTCR 172

  Fly   353 IELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSG---------WSFTQMSVVLVENDSQRRYN 408
            :..|          :..:|:......|....|.|.|         ||.....|    |..:::|.
Worm   173 MTFG----------SWSFDNSLIDYFPRTFTNGPIGLANFLENDAWSVLGTKV----NREEKKYT 223

  Fly   409 --PKGMMQKMTGDVAIEFTL-------QRNRSFYMTVFYLPLIACQMFLILSFV----------- 453
              |            :.:||       ||...:|:.....|........|:.|.
Worm   224 CCP------------VNYTLLHYDVVIQRKPLYYVLNLIAPTAVITFISIIGFFTSVNPFTNFCN 276

  Fly   454 ----LRSTRRSSLIL-IALLIAAWGLMYMT--RYASPHYVPPMMTAYKVIMMTTTYCYILHI--- 508
                :...|:..:.| |..|::...:::|.  :..|.....|::..:..:|:|     |:.:
Worm   277 VSSSVHDLRQEKITLGITTLLSMSIMIFMVSDKMPSTSTCVPLIALFYTLMIT-----IISVGTL 336

  Fly   509 ---CIIWLDLY-----PPRSKAPGWLVRV 529
               .:|::...     ||.||...|..|:
Worm   337 AASSVIFVQKLGSIGNPPASKTMKWTHRI 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	40/223 (18%)
acr-23	NP_504024.2	Neur_chan_LBD	27..242	CDD:280998	41/224 (18%)
acr-23	NP_504024.2	Neur_chan_memb	249..529	CDD:280999	20/122 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810