DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lev-8

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_509932.2	Gene:	lev-8 / 191600	WormBaseID:	WBGene00002975	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	350	Identity:	63/350 - (18%)
Similarity:	136/350 - (38%)	Gaps:	59/350 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 KLLSHLNIQAENASMPANLSSISFHFQ-----TRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPE 277
            :||.:|......|..|.:.:|.:...:     .|.:..::.:.:|.|.:.:.|.|.|.:|.|.|.
Worm    31 QLLENLLTDYNKAVRPVHNASDALKVKFGANLCRLIDVDEVNQVLTTSLWLEMQWYDKKLTWNPT 95

  Fly   278 DFGSLESFEHPDLRIWKPHMNVLNGA-------LQSMGQVLQSYELMVYANGSITLYAQNLQLAS 335
            |:|.:|....|..:||.|.:.:.|.|       :.|:.:: ..:..:|:...||        ..|
Worm    96 DWGGVEYIHIPSDQIWIPDIVLYNNADGEPHITITSLAKI-DHHGRVVWQPPSI--------YKS 151

  Fly   336 WCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNE--------------HVNTP 386
            :|..:.:.:|.:..||:::.|     |..|.....|..:.|:..::              ::...
Worm   152 FCPINIKYFPYDWQTCEMKFG-----GWSNDGETLDLYQIPVDVDDIPQVKRQDDGVEFLYLEKG 211

  Fly   387 SGWSFTQMSVV--LVENDSQR--RYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMF 447
            .|.||...|..  |:...|.|  :..|....|:...|:.....::|...|:.....:|.:.....
Worm   212 LGLSFYHESAEWDLLSATSSRYAQIYPGCCGQQYYIDIKYRIIIRRKAIFFTVTLTIPCMLIANV 276

  Fly   448 LILSFVLRSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVIMMTTTYCYI-----LH 507
            ....|::..........|::|: |:.:.|:...   ..:||...:..:|.:...:..:     :.
Worm   277 TPFVFLILPNEHKMTYSISVLV-AFSVFYLVLI---DLIPPTSLSLSLIGIYLLFTLLMVSVSII 337

  Fly   508 ICIIWLDLYPPRSKAPG------WL 526
            :.::.:::|..::.:.|      ||
Worm   338 LSVVTINMYRKQAFSSGMSHWQRWL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	48/240 (20%)
lev-8	NP_509932.2	LIC	10..499	CDD:273305	62/349 (18%)
		Neur_chan_LBD	30..258	CDD:280998	48/240 (20%)
		Neur_chan_memb	268..497	CDD:280999	12/98 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810