DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-30

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_500015.3	Gene:	lgc-30 / 186551	WormBaseID:	WBGene00019069	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	320	Identity:	61/320 - (19%)
Similarity:	122/320 - (38%)	Gaps:	56/320 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 EQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYE 315
            :|.::|.....::.:||.|..:.||||.||.:|....|...||||...:.:.....:........
Worm   105 DQRNNLATVSAYLDVHWNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSVYGRVPDYAPDAS 169

  Fly   316 LMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELG--------LNGQEGQENVAL--IY 370
            ..::.||.:.::. ::...|:|..:.:.:|.:..||....|        :|....::.:||  .|
Worm   170 AELHYNGLVRMFV-SISSKSFCPINFKRFPFDSQTCSFSCGSWAYQSNIVNLVAAKQEIALEDFY 233

  Fly   371 DDQRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMT 435
            |:|.              |..|...:.   |.:.|..:.......|   |.::..|:|...:|:.
Worm   234 DNQE--------------WLLTDARLF---NGTTRNVSAANESFSM---VYMQLDLKRQSFYYVF 278

  Fly   436 VFYLPLIACQMFLILSF---VLRSTRRSS------LILIALLIAAWGLMYMTRYASPHYVPPMMT 491
            ....|.....:..::.|   :..:.||.|      :.|:::.:....|:...::|. ..||....
Worm   279 NLVFPTTLVSLVAVIGFHAPINATGRRESKFRLGIMTLLSMSVMLLMLVGEMKFAM-ESVPGQRG 342

  Fly   492 AYKVIMMTTTYCYILHICIIWL--------------DLYPPRSKAPGWLVRVINSNVLRC 537
            ::..:.:...| |:..|||:.:              .|..|..::..|.:|.:.:..|.|
Worm   343 SFSDVPLMGIY-YMTLICIVSIATCTSSIFVHLEKFALRNPSWQSVPWYIRWLAAKKLFC 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	38/187 (20%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:367255	38/187 (20%)
		LGIC_TM_cation	274..>374	CDD:349853	16/101 (16%)
		TM1 helix	278..298	CDD:349853	2/19 (11%)
		TM2 helix	310..338	CDD:349853	3/28 (11%)
		TM3 helix	352..374	CDD:349853	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5703
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900