DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and acr-21

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001355512.1	Gene:	acr-21 / 185004	WormBaseID:	WBGene00000060	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	321	Identity:	69/321 - (21%)
Similarity:	132/321 - (41%)	Gaps:	43/321 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 NYLSFSSFGSNTARWFYDCGFDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHF 243
            |.|| |....|..|.:.|..:| |.:|:.|.|                  ::..|.|   ::|.|
Worm    21 NELS-SRADQNVMRLYRDLLYD-YNNEVRPSV------------------HSKEPIN---VTFVF 62

  Fly   244 Q-TRSLAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSM 307
            . |:.:..::.:.:|.|...:.:||.|.:|||.|..:.::.....|..:||||.:.:.|.|....
Worm    63 SLTQIIDVDERNQILTTNSWIRLHWVDYKLVWDPRLYQNVTRIHIPSDKIWKPDIILYNNADAQY 127

  Fly   308 GQVLQSYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDD 372
            .:.:.|.:::|...|:|. :..:....|.|....:::|.:|.||.::......:|.:...|:..:
Worm   128 MKSVMSTDVIVDYLGNIH-WPLSAIFTSSCPLDVKHYPFDRQTCILKYASWAYDGTKIDLLLKSE 191

  Fly   373 QRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVF 437
            |..  ..|...||.  ||       |:...:::.........:....:.:..|::|...||:...
Worm   192 QGD--LTNYITNTE--WS-------LIGIRAEKNQVIYSCCPEPYPFIDVHVTIERRAMFYVFNL 245

  Fly   438 YLPLIACQMFLILSFVL--RSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVI 496
            .||.:...:..::.|.:  .|..:.:|.:.:||.....||.:.     ..:||...|..:|
Worm   246 ILPCVLISLIALMGFYMPTDSGEKVTLGITSLLSTTVFLMMVA-----EGMPPTAEALPLI 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052	5/11 (45%)
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	41/217 (19%)
acr-21	NP_001355512.1	LGIC_ECD_nAChR	56..237	CDD:349798	40/195 (21%)
		Cys-loop	156..170	CDD:349798	3/13 (23%)
		LGIC_TM_cation	239..>327	CDD:349853	15/68 (22%)
		TM1 helix	239..263	CDD:349853	5/23 (22%)
		TM2 helix	271..292	CDD:349853	5/25 (20%)
		TM3 helix	303..325	CDD:349853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810