DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-23

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_510016.2	Gene:	lgc-23 / 182622	WormBaseID:	WBGene00007594	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	64/359 - (17%)
Similarity:	128/359 - (35%)	Gaps:	74/359 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 KEETKTEKLLSHLNIQAE-----NASMPANL-----SSISFHFQTRSLAYEQTSSLLQTRMHMMM 265
            :|..:.:..|.|..::.:     :.|||:.|     :.:.....:|   .::.:..|...:.:..
Worm    23 EESERHQAYLDHRKLKEDVLGPLDGSMPSELPVFIGAQLKLDHISR---VDEKTGFLTLALTVKF 84

  Fly   266 HWRDSRLVWKPEDFGS-----LESFEHPDLRIWKPHMNVLNGALQSMGQVLQ-----SYELMVYA 320
            .|.|.||.|.|..:..     ||..:....:||||.:.:.|...:...:.:.     ..|:.:::
Worm    85 MWSDERLQWDPSHYSGFTRTRLEFVDFWLYQIWKPRIYMTNTYERRQSKTIDLLSNTLVEMDIHS 149

  Fly   321 NGSITLYAQNLQLASWCVDSARNWPSERVTC-----------DIELGLNGQEGQ--------ENV 366
            .|.: :....:.|.::|....:.:|.:...|           ||.||.:..:.:        :.|
Worm   150 KGFV-MTTTKILLKTFCFLDFKGYPHDFQNCSFSFIPNMNANDIFLGSSMLKAKFTKDFTDPQQV 213

  Fly   367 ALIYDDQRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRS 431
            ..:.|.|...:.      |...:.|...   :|.:|..|  .|:.:::..   |:....|||...
Worm   214 VRVQDFQINDVV------TEDLYLFMNR---IVLHDLTR--EPRSLVRSF---VSFTIVLQRKNV 264

  Fly   432 FYMTVFYLPLIACQMFLILSFVLRSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVI 496
            :.....|.|:|.....||:|..|.|.....|::..|:..     |:..:.....:|........|
Worm   265 YVHLQLYAPMIFICTCLIISGFLPSEYALPLLVFNLISE-----YLYFHNIKDVLPTDFDGTPTI 324

  Fly   497 MMTTTYCYILHICIIWLDLYPPRSKAPGWLVRVI 530
            .:..|:.....:.||            ||.:.:|
Worm   325 ALIATFTLAETMSII------------GWKMFII 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	44/255 (17%)
lgc-23	NP_510016.2	Neur_chan_LBD	34..262	CDD:367255	42/245 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900