DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and lgc-21

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_510341.2	Gene:	lgc-21 / 181516	WormBaseID:	WBGene00007903	Length:	462	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	79/405 - (19%)
Similarity:	153/405 - (37%)	Gaps:	79/405 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 KTEKLLSHLNIQAENASMPANLSS---ISFHFQTRSLA-YEQTSSLLQTRMH--MMMHWRDSRLV 273
            ::.|.|:.|||....||:|.|..|   ::.:|...:|. :|....|....:|  :.:.|.|.||:
Worm    86 ESAKKLAKLNIPHAIASIPPNYLSQQPVTINFAQFTLQHFELNEHLKDISIHGYLELSWHDDRLM 150

  Fly   274 WKPEDFGS----LESFEHPDLRIWKPHMNVLN--GALQSMGQVLQSYELMVYANGSITLYAQNLQ 332
            |..:.:..    :.||.|    ||.|.:...|  ..|:: |...:..::.....|:::.... ..
Worm   151 WNQDTWKKNKLVVHSFHH----IWVPLLGSQNPENHLKN-GDAFEIRKVETTNQGNVSAKVA-FS 209

  Fly   333 LASWCVDS-ARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSFTQMSV 396
            |.::|.|: ..|:|::...|....    :..|:...:.:.....||..:.......||.   :|.
Worm   210 LRTFCDDTDFENYPNDVYKCCFSF----EPQQDREVIQFTSSGLPIFTDPKNFRDYGWG---VSG 267

  Fly   397 VLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLRSTRRSS 461
            .:.|:..    :|..:.|     :.....|:|..|.......:||.......:|..:..|.:
Worm   268 TVPESFD----DPSEIAQ-----LGFCLNLKRAHSSLKIELAIPLFITTALFLLPPLFGSVK--- 320

  Fly   462 LILIALLIAAWGLMYMTRYASPHYVPPMMTA----------------YKVIMMTTTYCYILHICI 510
             |.|.|.:...||.:||.......:.|.:::                :.:|.:||:  .|:..|:
Worm   321 -IQIYLKMFVMGLQFMTLLIFSTRIAPFLSSTASTPKPMRFLEIALVFNLISITTS--IIIFCCM 382

  Fly   511 IWLDLYPPRSKAPGWLVRVINSNVLRCILG-LRFSDSTDY----CDIQ------ENPWHHM---- 560
            ......||..:...:      :|.:...|| |..|...:|    .|.|      :..|.::
Worm   383 QVKRTLPPWGRVTQF------ANFINGFLGVLNISGVEEYNLDKYDEQVSQNSYQKDWANVFRAA 441

  Fly   561 -AKILNNLSSILVII 574
             |.::..:|:|::.:
Worm   442 HAVLMGTISAIVIFV 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	46/226 (20%)
lgc-21	NP_510341.2	LGIC_ECD	113..290	CDD:355788	36/198 (18%)
lgc-21	NP_510341.2	Cys-loop	214..229	CDD:349787	4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900