DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Htr3a

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_038589.2	Gene:	Htr3a / 15561	MGIID:	96282	Length:	489	Species:	Mus musculus

Alignment Length:	309	Identity:	66/309 - (21%)
Similarity:	116/309 - (37%)	Gaps:	40/309 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 LAYEQTSSLLQTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQ 312
            |..::.:.:|.|.:....:|.|..|.|.||||.::.....|...||.|  ::|......:|:...
Mouse    76 LNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVP--DILINEFVDVGKSPN 138

  Fly   313 SYELMVYANGSITLYAQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQE-NVALIYDDQRKP 376
            ...:.|:..|.:..| :.|||.:.|.....|:|.:...|.:.........|: |:.|    .|.|
Mouse   139 IPYVYVHHRGEVQNY-KPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITL----WRSP 198

  Fly   377 IAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFT-------LQRNRSFYM 434
                |.|.:.......|....|:|...|        .::.:.|::..:.       ::|...||.
Mouse   199 ----EEVRSDKSIFINQGEWELLEVFPQ--------FKEFSIDISNSYAEMKFYVIIRRRPLFYA 251

  Fly   435 TVFYLPLIACQMFLILSFVL---RSTRRSSLILIALLIAAWGLMYMTRYASPHYVPPMMTAYKVI 496
            ....||.|...:..|:.|.|   ...|.|..|.:.|..:.:.::......:.....|::..|.|:
Mouse   252 VSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVV 316

  Fly   497 MMTTTYCYILH-ICIIWL----DLYPPRSKAPGWLVRVINSNV--LRCI 538
            .|......:.. |.|:.|    ||..|   .|.||..::...:  :.|:
Mouse   317 CMALLVISLAETIFIVRLVHKQDLQRP---VPDWLRHLVLDRIAWILCL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	39/188 (21%)
Htr3a	NP_038589.2	LIC	5..483	CDD:273305	66/309 (21%)
Htr3a	NP_038589.2	HA-stretch	425..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900