DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Chrnb1

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_033731.3	Gene:	Chrnb1 / 11443	MGIID:	87890	Length:	501	Species:	Mus musculus

Alignment Length:	370	Identity:	79/370 - (21%)
Similarity:	141/370 - (38%)	Gaps:	52/370 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 GSEIAPIVK----EETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLAYEQTSSL------L 257
            |:.:||..:    |....:||.|:.:.....|....:...:|.     .|...|..||      :
Mouse    14 GTPLAPGARGSEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSI-----GLTLAQLISLNEKDEEM 73

  Fly   258 QTRMHMMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANG 322
            .|::::.:.|.|.||.|.|.:...::|.......:|.|.:.:||.. .....|.....::|...|
Mouse    74 STKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNN-DGNFDVALDINVVVSFEG 137

  Fly   323 SIT-----LYAQNLQLA------SW--C--VDSARNWPSERVTCDIELGLNGQEGQENVALIYDD 372
            |:.     ||..:..:.      .|  |  |.|:.::.|..|:....|...|:|.||    :|..
Mouse   138 SVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQE----VYIH 198

  Fly   373 QRKPIAPNEHVNTPSGWSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVF 437
            :...|...:       |........|::....:|...:|..:    :|.....::|...||:...
Mouse   199 EGTFIENGQ-------WEIIHKPSRLIQLPGDQRGGKEGHHE----EVIFYLIIRRKPLFYLVNV 252

  Fly   438 YLPLIACQMFLILSFVL--RSTRRSSLILIALL-IAAWGLMYMTRYASPHYVPPMMTAYKVI-MM 498
            ..|.|...:..|..|.|  .:..:..|.:.||| :..:.|:...:........|::..|.:. |:
Mouse   253 IAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMV 317

  Fly   499 TTTYCYILHICIIWLDLYPPRS-KAPGWLVRVINSNVLRCILGLR 542
            ..|:..||.:.::.|....|.: :.|.| ||.|..:.|...|||:
Mouse   318 LVTFSVILSVVVLNLHHRSPHTHQMPFW-VRQIFIHKLPPYLGLK 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	46/237 (19%)
Chrnb1	NP_033731.3	LIC	24..488	CDD:273305	76/360 (21%)
		Neur_chan_LBD	27..245	CDD:280998	47/238 (20%)
		Neur_chan_memb	252..487	CDD:280999	27/111 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..382		79/370 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900