DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and CHRNB4

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_000741.1	Gene:	CHRNB4 / 1143	HGNCID:	1964	Length:	498	Species:	Homo sapiens

Alignment Length:	349	Identity:	80/349 - (22%)
Similarity:	136/349 - (38%)	Gaps:	64/349 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EKLLSHL--NIQAENASMPANLSS--ISFHFQ---TRSLAYEQTSSLLQTRMHMMMHWRDSRLVW 274
            |||:..|  ..:..|...||..||  ||...|   .:.::..:...::.|.:.:...|.|.||.|
Human    28 EKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTW 92

  Fly   275 KPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVY------ANGSITLYAQNLQL 333
            ....:..:.....|..|||.|.:.:.|.|       ..:||:.||      :|||: |:......
Human    93 NSSRYEGVNILRIPAKRIWLPDIVLYNNA-------DGTYEVSVYTNLIVRSNGSV-LWLPPAIY 149

  Fly   334 ASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQR------KPIAPNEHVNTPSG-WSF 391
            .|.|....:.:|.::..|.::..          :..||...      .|.|..:.. |||| |.
Human   150 KSACKIEVKYFPFDQQNCTLKFR----------SWTYDHTEIDMVLMTPTASMDDF-TPSGEWD- 202

  Fly   392 TQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLRS 456
                  :|....:|..||:   .....||..:|.::|...||.....:|.:...:..||.|.|.|
Human   203 ------IVALPGRRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPS 258

  Fly   457 T--RRSSLILIALLIAAWGLMYMTRYASPHYVP-PMMTAYKVI-MMTTTYCYILHICIIWLDLYP 517
            .  .:.:|.:..||...:.|:.:::...|..:. |::..|.:. |:..|:..:..:|::.:....
Human   259 DCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRS 323

  Fly   518 P--RSKAPGWLVRVINSNVLRCIL 539
            |  .:.|| |        |.||.|
Human   324 PSTHTMAP-W--------VKRCFL 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	53/231 (23%)
CHRNB4	NP_000741.1	Neur_chan_LBD	5..480	CDD:332142	80/349 (23%)
CHRNB4	NP_000741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810