DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and CHRNB2

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_000739.1	Gene:	CHRNB2 / 1141	HGNCID:	1962	Length:	502	Species:	Homo sapiens

Alignment Length:	380	Identity:	87/380 - (22%)
Similarity:	147/380 - (38%)	Gaps:	79/380 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 EETKTEKLL--SHLNIQAENASMPANLSSISFHFQTRSL-AYEQTSSLLQTRMHMMMHWRDSRLV 273
            ||...|.||  |..|.....|:..:.|.::........| :..:...::.|.:.:...|.|.||.
Human    29 EERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLT 93

  Fly   274 WKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYAN------GSI-----TLY 327
            ||||:|.:::....|...||.|.:.:.|.| ..|      ||:..|:|      |||     .:|
Human    94 WKPEEFDNMKKVRLPSKHIWLPDVVLYNNA-DGM------YEVSFYSNAVVSYDGSIFWLPPAIY 151

  Fly   328 --AQNLQLASW------CVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVN 384
              |..:::..:      |....|:|..:|...|:.|       :..||.:.|            .
Human   152 KSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL-------KSEVASLDD------------F 197

  Fly   385 TPSG-WSFTQMSVVLVENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFL 448
            |||| |.       :|....:|..||.   .....|:..:|.::|...||.....:|.:......
Human   198 TPSGEWD-------IVALPGRRNENPD---DSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLA 252

  Fly   449 ILSFVLRST--RRSSLILIALLIAAWGLMYMTRYASPHYVP-PMMTAYKVI-MMTTTYCYILHIC 509
            ||.|.|.|.  .:.:|.:..||.....|:.:::...|..:. |::..|.:. |:..|:..:..:|
Human   253 ILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVC 317

  Fly   510 IIWLDLYPP--RSKAPGWLVRVINSNVLRCILGLRFSDSTDYCDIQENPWHHMAK 562
            ::.:....|  .:.|| | |:|:....|..:|            ..:.|.||.|:
Human   318 VLNVHHRSPTTHTMAP-W-VKVVFLEKLPALL------------FMQQPRHHCAR 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	56/239 (23%)
CHRNB2	NP_000739.1	LIC	29..479	CDD:273305	87/380 (23%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	55/238 (23%)
		Cys-loop	155..169	CDD:349826	0/13 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810