DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NtR and CHRNA3

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_000734.2	Gene:	CHRNA3 / 1136	HGNCID:	1957	Length:	505	Species:	Homo sapiens

Alignment Length:	345	Identity:	69/345 - (20%)
Similarity:	138/345 - (40%)	Gaps:	34/345 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 IAPIVKEETKTEKLLSHLNIQAENASMP-ANLSS-ISFHFQ---TRSLAYEQTSSLLQTRMHMMM 265
            :.|:.:......:|...|.........| ||:|. :..||:   ::.:..::.:.:::|.:.:..
Human    25 LLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQ 89

  Fly   266 HWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYAQN 330
            .|.|.:|.|.|.|:|..|....|..:||||.:.:.|.|:... ||....:.::...|.:|.....
Human    90 IWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDF-QVDDKTKALLKYTGEVTWIPPA 153

  Fly   331 LQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQR-KPIAPNEHVNTPSGWSFTQM 394
            : ..|.|......:|.:...|.::.|          :..||..: ..:.....:|....|...:.
Human   154 I-FKSSCKIDVTYFPFDYQNCTMKFG----------SWSYDKAKIDLVLIGSSMNLKDYWESGEW 207

  Fly   395 SVVLV---ENDSQRRYNPKGMMQKMTGDVAIEFTLQRNRSFYMTVFYLPLIACQMFLILSFVLRS 456
            :::..   ::|.  :||   ..:::..|:.....::|...||.....:|.:......:|.|.|.|
Human   208 AIIKAPGYKHDI--KYN---CCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS 267

  Fly   457 T--RRSSLILIALLIAAWGLMYMTR-YASPHYVPPMMTAYKVIMMTTTYCYILHICIIWLDLY-- 516
            .  .:.:|.:..||.....|:.:|. ..|...|.|::..|.:..|......|: |.:..|:::
Human   268 DCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIV-ITVFVLNVHYR 331

  Fly   517 -PPRSKAPGWLVRVINSNVL 535
             |.....|.| |:.:..|:|
Human   332 TPTTHTMPSW-VKTVFLNLL 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	41/225 (18%)
CHRNA3	NP_000734.2	Neur_chan_LBD	30..496	CDD:332142	68/340 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810