DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Chrna2

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_659052.1	Gene:	Chrna2 / 110902	MGIID:	87886	Length:	512	Species:	Mus musculus

Alignment Length:	327	Identity:	67/327 - (20%)
Similarity:	129/327 - (39%)	Gaps:	32/327 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 EKLLSHL----NIQAENASMPANLSSISFHFQTRSLA-YEQTSSLLQTRMHMMMHWRDSRLVWKP 276
            ::|..||    |..|......:::..:.|......|. .::.:.::.|.:.:...|.|.:|.|.|
Mouse    37 DRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDP 101

  Fly   277 EDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLYAQNLQLASWCVDSA 341
            .:||::.|...|...||.|.:.:.|.| .....|....:..::..|::......:..:|..:| .
Mouse   102 AEFGNITSLRVPSEMIWIPDIVLYNNA-DGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSID-V 164

  Fly   342 RNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEH-VNTPSGWSFTQMSVVLVENDSQR 405
            ..:|.::..|.::.|          :..||..:..:...|. |:....|...:.:::    ::..
Mouse   165 TFFPFDQQNCKMKFG----------SWTYDKAKIDLEQMERTVDLKDYWESGEWAII----NATG 215

  Fly   406 RYNPK--GMMQKMTGDVAIEFTLQRNRSFYMTVFYLP--LIACQMFLILSFVLRSTRRSSLILIA 466
            .||.|  ....::..||...|.::|...||.....:|  ||:|...|:.........:.:|.:..
Mouse   216 TYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISV 280

  Fly   467 LLIAAWGLMYMTR-YASPHYVPPMMTAYKVIMMTTTYCYILHICIIWLDLY---PPRSKAPGWLV 527
            ||.....|:.:|. ..|...|.|::..|.:..|......|: |.:..|:::   |.....|.| |
Mouse   281 LLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIV-ITVFVLNVHHRSPSTHNMPNW-V 343

  Fly   528 RV 529
            ||
Mouse   344 RV 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	40/219 (18%)
Chrna2	NP_659052.1	LIC	15..505	CDD:273305	67/327 (20%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	41/220 (19%)
		Cys-loop	160..174	CDD:349816	2/14 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900