DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NtR and Chrnb3

DIOPT Version :9

Sequence 1:	NP_651958.2	Gene:	NtR / 43935	FlyBaseID:	FBgn0029147	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_775304.1	Gene:	Chrnb3 / 108043	MGIID:	106212	Length:	464	Species:	Mus musculus

Alignment Length:	469	Identity:	84/469 - (17%)
Similarity:	160/469 - (34%)	Gaps:	151/469 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 FDGYGSEIAPIVKEETKTEKLLSHLNIQAENASMPANLSSISFHFQTRSLA-YEQTSSLLQTRMH 262
            |.||...:.|::                  |:|   ::..:.|..:...|. .::.:.|:.|.:.
Mouse    43 FQGYQKCVRPVL------------------NSS---DIIKVYFGLKISQLVDVDEKNQLMTTNVW 86

  Fly   263 MMMHWRDSRLVWKPEDFGSLESFEHPDLRIWKPHMNVLNGALQSMGQVLQSYELMVYANGSITLY 327
            :...|.|.:|.|.|||:|.:.|.:.|...:|.|.:.:...|.......|.: :.:|.::|::: :
Mouse    87 LKQEWTDQKLRWNPEDYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMT-KAIVKSSGTVS-W 149

  Fly   328 AQNLQLASWCVDSARNWPSERVTCDIELGLNGQEGQENVALIYDDQRKPIAPNEHVNTPSGWSF- 391
            .......|.|......:|.::..|.::.|                               .|::
Mouse   150 TPPASYKSSCTMDVTFFPFDKQNCSMKFG-------------------------------SWTYD 183

  Fly   392 -TQMSVVLVENDSQRR----------YNPKGMM-QKMTG-----DVAIEFTLQRNRSFYMTVFYL 439
             |.:.::|:..:..|:          .|.|||. .:..|     .|...|.|:|...||.....:
Mouse   184 GTMVDLILINENVDRKDFFDNGEWEILNAKGMKGNRREGFYSYPFVTYSFVLRRLPLFYTLFLII 248

  Fly   440 PLIACQMFLILSFVLRSTRRSSL-----ILIALLIAAWGLMYMTRYASPHYVPPMMTAYKV-IMM 498
            |.:......:|.|.|.|.....|     :|::|.:  :.|:......|...|.|::..|.: ||:
Mouse   249 PCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTV--FLLVIEEIIPSSSKVIPLIGEYLLFIMI 311

  Fly   499 TTTYCYILHICII---------------------------WLDLYPP----------------RS 520
            ..|...|:.:.:|                           ||.:..|                |.
Mouse   312 FVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLEKLPRWLCMKDPRDRFSFPDGTESKGTVRG 376

  Fly   521 KAPGWLVRVINSNVLRCILGL--RFSDSTDYCD------------IQENPWHHMAKILNN----- 566
            |.||...:...|:..|.::..  :.|:|..|..            :|:  |..:|::|:.
Mouse   377 KFPGKKKQTPTSDGERVLVAFLEKASESIRYISRHVKKEHFISQVVQD--WKFVAQVLDRIFLWL 439

  Fly   567 ------LSSILVII 574
                  |.|:|:.|
Mouse   440 FLTASVLGSVLIFI 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NtR	NP_651958.2	Methyltransf_FA	90..191	CDD:289052
NtR	NP_651958.2	Neur_chan_LBD	212..429	CDD:280998	39/235 (17%)
Chrnb3	NP_775304.1	LIC	6..455	CDD:273305	84/469 (18%)
		Neur_chan_LBD	35..239	CDD:280998	44/249 (18%)
		Neur_chan_memb	246..452	CDD:280999	37/209 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..387		4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810