DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prc and FLG

DIOPT Version :9

Sequence 1:	NP_524658.2	Gene:	prc / 43930	FlyBaseID:	FBgn0028573	Length:	1713	Species:	Drosophila melanogaster
Sequence 2:	NP_002007.1	Gene:	FLG / 2312	HGNCID:	3748	Length:	4061	Species:	Homo sapiens

Alignment Length:	2080	Identity:	425/2080 - (20%)
Similarity:	644/2080 - (30%)	Gaps:	592/2080 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NEVSSLNDLQR-----EKRSG------RGYSRGQTQSQYLNFGKPEED----GKAEAEATENGSR 75
            :.||..:|.:|     |:.||      .|.||.|::....:.|..:||    |.:...:.::|:.
Human  1268 SSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTH 1332

  Fly    76 STVSGTHGM---GQAQSQFSSGDCNGCSGYQTDYPSSGRILDASGSGGIG-RPDSIISLPGGVGG 136
            .|.|.:||.   ...|::.|.|:.:|....|:        .|:|...||| |..|......|..|
Human  1333 HTESSSHGQAVSSHEQARSSPGERHGSRHQQS--------ADSSRHSGIGHRQASSAVRDSGHRG 1389

  Fly   137 QTGA---GQAGYGSQLGVGAQAGAGQPGYGDQPGVGTQPGVGQPGYGS----------------- 181
            .:|:   ...|:.......:.:..||.|...|.  ..:...||.|..|
Human  1390 SSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQS--HKESARGQSGESSGRSRSFLYQVSSHEQSE 1452

  Fly   182 ------QPGIGGQTG-------------AGQPGYGSQPGIGGQTGAGQPG-YGSQPVVGAQTGTG 226
                  .|..||:.|             |.|.|..:..|..|.:..|:.| |..|.|    ..:|
Human  1453 STHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSV----DRSG 1513

  Fly   227 QPGY---GAQPGVGTQTGAGQPGYGS---------QPGIGGQ-TGARQPGYVTQPGVGAQTGIGQ 278
            ..||   ...|...:....||.|..|         |.|.|.: :|:|.....|:.|....:.:||
Human  1514 HSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQ 1578

  Fly   279 PGYGA-------QPGILGQ---------------TGAGQPGYGSQPGIGGQTGAGQPGYGTQPGV 321
             |..|       |...:.|               ..|.:..|||        ...|..:|::...
Human  1579 -GESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGS--------AREQSRHGSRNPR 1634

  Fly   322 GAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGIGGQTGAGQPG--YG----------TQPGVGA 374
            ..|......|:.|:....:.|...:...|.|.....:.....||  :|          |..|.|.
Human  1635 SHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGR 1699

  Fly   375 QTGAGQPGYGAQPGVGAQTGAGQPGYGSQPGIGGQTGAGQPG---YGSQPGIGGQTGARQPGYGS 436
            :..:...|.....|......:...|:..:......:..||.|   ...|....||:|.|....||
Human  1700 RQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSHQESTRGQSGERSGRSGS 1764

  Fly   437 --------------QPGVGAQTGAGQPGYGAQPGVGAQTGAGQPGYGSQPGIGGQTGAGQPGYGS 487
                          ....|..||..|.....|....::..|.|.|..:..|..|.:..|:.|...
Human  1765 FLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHY 1829

  Fly   488 QPGVGAQTGAGQPGYGAQPGVGAQTGAGQPGYGS---QPGIGGQTGAGQPGYGTQ---------P 540
            :..|.:...:|...........:....||.|..|   |.....|:|.|....|::         .
Human  1830 EQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEASSRADS 1894

  Fly   541 GVGAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGIGGQTGAGQPGYGTQPGVGAQTGTGQPGYG 605
            ...:|.|.||..       |.:|...|         |..........|........:|:....:.
Human  1895 SRHSQVGQGQSS-------GPRTSRNQ---------GSSVSQDSDSQGHSEDSERWSGSASRNHL 1943

  Fly   606 AQPGVGTQTGAGQPG--YGSQPGYGTQPGVGAQTGT-----GQPGYGAQPGVGGQTGAGQPGYGT 663
            ......::.|:..||  :..:.|:|.......|:||     ...|..|......::.||: .:|:
Human  1944 GSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQARSSAGE-RHGS 2007

  Fly   664 QPGIGGQTGAGQPGYGSQPGIGGQTGGGQPGY-GSQIGGQTGAGQPSYGSQPGVGAQNGAGQPGY 727
            ...:.....:...|.|...........|..|| |||.....|..:.|  ....|.||..||....
Human  2008 HHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDS--DTQSVSAQGKAGPHQQ 2070

  Fly   728 GTQPVIGGQTGAGQPGYGGQTGVGGSPGFLTQ-------PGIGGISGP-IGGKLG--------GG 776
            ..:....||:|...         |.|..||.|       ....|.|.| .||:.|        ..
Human  2071 SHKESARGQSGESS---------GRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSS 2126

  Fly   777 QSEAAKPGYWAQPGIGGPSRYGSQPGIGDQTGTGQSGYGG--------------QPGISG----- 822
            :..|::.|.....|..||||.|.| |...:....:||:.|              ..|.||
Human  2127 RHSASQEGQDTIRGHPGPSRGGRQ-GSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSAS 2190

  Fly   823 -------QTGGGQPGYG---------GQATISGLPGYGTQPGIGALTAVPGG------------- 858
                   |:|.|....|         ..::...|.|.|...  |..|:.|.|
Human  2191 RKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSS--GPRTSRPRGSSVSQDSDSEGHS 2253

  Fly   859 -------------HYG----------------YETQPGIG------GQTGTN--QPGFGGQPGIG 886
                         |:|                :|.:.|.|      .|:||:  :...|||....
Human  2254 EDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASS 2318

  Fly   887 GQTGAGQPG--YGFIGQ--------PGIG-GQTGTSGRQPGYGTQPGIGGQTAAGQPGYGSQT-- 938
            .:......|  :|...|        .||| ||..::.|..|:   .|..|..|:...|:...:
Human  2319 HEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGH---RGSSGSQASDSEGHSEDSDT 2380

  Fly   939 ---GVGGQIGAGQPGY-----GSQPGIGGQTGA---------------GQPGYGAQPGFGGQPGY 980
               ...||.|..|..:     |...|..|::|:               |:.|...    ||:.|.
Human  2381 QSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTST----GGRQGS 2441

  Fly   981 GNQPG----------VGGQTGAGQPGYGSQPGIGGQTG---------AGQPG-----------YG 1015
            .::..          .|..|..|.||..|    ||:.|         :|..|           ..
Human  2442 HHKQARDSSRHSTSQEGQDTIHGHPGSSS----GGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSD 2502

  Fly  1016 AQPGFGGQLGYGNQPGVGGQTGAGQPGYGSQ----PGVGGQTGAGQPGYGVIPG----------F 1066
            |..|..|......|.....|:|.|....||:    ......:|..|.|.|...|          |
Human  2503 ASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSF 2567

  Fly  1067 GGQPGIGGQT--------AAGKPGYGG------------------QPGIGGSPVYGTQQGTGGQS 1105
            .......|.:        :|.:..:|.                  :.|.|.|.....|.||....
Human  2568 SQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQ 2632

  Fly  1106 GISGGQPGYGTQPGQTGAGQPGYGS----------LPGTG-GQAT-----AGQPGYGPGSQPG-- 1152
            ..||||.....:..::.||: .:||          ..|.| |||:     :|..||. |||..
Human  2633 TSSGGQAASSHEQARSSAGE-RHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYS-GSQASDN 2695

  Fly  1153 ------IGGQTVGGHGGYGSQPGIGGAPVYGTQPGGGGQTGVIGGQPGQIGDRV----------G 1201
                  ...|:|..||..||..       ...|....|::|...|..|....:|          |
Human  2696 EGHSEDSDTQSVSAHGQAGSHQ-------QSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHG 2753

  Fly  1202 QPGYGTQTGQIGA-------PGRYT---DGSQTVPGAVGT--GG---------VVAAGTSGADDA 1245
            ..|..|: |:.|:       ..|::   ||..|:.|..|:  ||         |.::|.||:..:
Human  2754 WTGPSTR-GRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHS 2817

  Fly  1246 F--SQAESSIGDGQ-----ASASAQGKKNGGTAKTQVSGTYSSGGTFSASAMTSDADRAASAQVT 1303
            .  ||..|....||     ||.:.:.::..|      .|:..||.....::..:|..|
Human  2818 HTTSQGRSDASRGQSGSRSASRTTRNEEQSG------DGSRHSGSRHHEASTHADISR------- 2869

  Fly  1304 GNADGAVSQSQGSGGPAQSQAQVQVAKDGGTKASSQSGGIIQQSQSEVHANDK---GGLADAQSS 1365
                             .||| ||...:|..::..|...:.|.|.||.|:.|.   .|.|.....
Human  2870 -----------------HSQA-VQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHH 2916

  Fly  1366 GPGQTSSQAQIGFRPGQEANPIAANGGGQASSS--SGTHSSQSSSQIHGTSSFGVSYHGAAQSAS 1428
            |..|  .|.:.|.|..:......|..|..|.||  |||..:|:||.....||     |..|:|::
Human  2917 GSAQ--EQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASS-----HEQARSSA 2974

  Fly  1429 GTKEQVATYREANRELFNTISQFGNNANAVTDRADAVYSGPALTDESDRVPEAQLKSTKPKEEAE 1493
            |.:......:.|:....:.|.. |..::||.|.....|||...:|......::..:|.....:|.
Human  2975 GERHGSHHQQSADSSRHSGIGH-GQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAG 3038

  Fly  1494 QVVSKLDHPEPVQYDDEDEADPDEYDEDEYYEEKPVKLEESPKSSTIVAPTEATPRPKTYNQSSP 1558
            .  .:..|.|..:   ....:...:.....|:   |...|..:||              :..:.|
Human  3039 S--HQQSHQESAR---GRSGETSGHSGSFLYQ---VSTHEQSESS--------------HGWTGP 3081

  Fly  1559 -TQSQQTVVVPVPGEKYQVVQ-------KQNGKATINAEPSTTEAIPPGFRGTVNVEKKFHTKAL 1615
             |:.:|       |.:::..|       .|.|:.||...|.::.....|:....:|:...|:.:.
Human  3082 STRGRQ-------GSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSH 3139

  Fly  1616 ELHAPKGVEITPDTSDEGPVRGDKPLRRAPDSYVTVTKSVTGSMDNTKNPPQENKNFQSTYYTKS 1680
            ..|          |:.:|  |.|            .::..:||...::....|.::..|:.::.|
Human  3140 HSH----------TTSQG--RSD------------ASRGQSGSRSASRTTRNEEQSGDSSRHSVS 3180

Fly 1681 1680
Human 3181 3180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prc	NP_524658.2	Pericardin_rpt	159..191	CDD:284468	11/67 (16%)
		Pericardin_rpt	176..208	CDD:284468	12/67 (18%)
		Loricrin	216..534	CDD:292475	76/384 (20%)
		Pericardin_rpt	227..259	CDD:284468	10/44 (23%)
		Pericardin_rpt	244..276	CDD:284468	10/41 (24%)
		Pericardin_rpt	295..326	CDD:284468	6/30 (20%)
		Pericardin_rpt	312..344	CDD:284468	6/31 (19%)
		Pericardin_rpt	346..378	CDD:284468	8/43 (19%)
		Pericardin_rpt	363..395	CDD:284468	8/43 (19%)
		Pericardin_rpt	397..429	CDD:284468	7/34 (21%)
		Pericardin_rpt	431..463	CDD:284468	7/45 (16%)
		Pericardin_rpt	465..497	CDD:284468	7/31 (23%)
		Pericardin_rpt	482..514	CDD:284468	3/31 (10%)
		Pericardin_rpt	516..547	CDD:284468	9/42 (21%)
		Pericardin_rpt	533..565	CDD:284468	7/40 (18%)
		Pericardin_rpt	567..598	CDD:284468	3/30 (10%)
		Pericardin_rpt	584..616	CDD:284468	2/31 (6%)
		Pericardin_rpt	624..656	CDD:284468	7/36 (19%)
		Pericardin_rpt	641..673	CDD:284468	5/31 (16%)
		Pericardin_rpt	841..873	CDD:284468	12/79 (15%)
		Pericardin_rpt	893..929	CDD:284468	12/46 (26%)
		Glutenin_hmw	925..>1382	CDD:281191	132/616 (21%)
		Pericardin_rpt	948..992	CDD:284468	12/73 (16%)
		Pericardin_rpt	977..1009	CDD:284468	10/50 (20%)
FLG	NP_002007.1	S-100	2..88	CDD:238131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..3971		425/2080 (20%)
		Filaggrin	388..428	CDD:281510
		Filaggrin	712..753	CDD:281510
		Filaggrin	915..955	CDD:281510
		Filaggrin	1036..1077	CDD:281510
		Filaggrin	1239..1279	CDD:281510	3/10 (30%)
		Filaggrin	1360..1401	CDD:281510	11/48 (23%)
		Filaggrin	1563..1603	CDD:281510	8/40 (20%)
		Filaggrin	1684..1725	CDD:281510	5/40 (13%)
		Filaggrin	2009..2050	CDD:281510	8/40 (20%)
		Filaggrin	2212..2252	CDD:281510	7/41 (17%)
		Filaggrin	2333..2374	CDD:281510	11/43 (26%)
		Filaggrin	2657..2698	CDD:281510	11/41 (27%)
		Filaggrin	2981..3022	CDD:281510	10/41 (24%)
		Filaggrin	3305..3346	CDD:281510
		Filaggrin	3629..3670	CDD:281510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BNT3
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900