DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prc and COL1A2

DIOPT Version :9

Sequence 1:	NP_524658.2	Gene:	prc / 43930	FlyBaseID:	FBgn0028573	Length:	1713	Species:	Drosophila melanogaster
Sequence 2:	NP_000080.2	Gene:	COL1A2 / 1278	HGNCID:	2198	Length:	1366	Species:	Homo sapiens

Alignment Length:	1493	Identity:	456/1493 - (30%)
Similarity:	573/1493 - (38%)	Gaps:	291/1493 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GDQPGVGTQPGVGQPGYGSQPGIGGQTG-AGQPGYGSQPGIGGQTGAGQPGYGSQPVVGAQTG-- 224
            ||:   |.:...|.||...:.|..|.|| .|.||....||:||...|...|.|    ||...|
Human    36 GDR---GPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKG----VGLGPGPM 93

  Fly   225 -----TGQPGYGAQPG-VGTQTGAGQPGYGSQPGIGGQTGARQPGYVTQPGVGAQTG-IGQPGYG 282
                 .|.||....|| .|.|..||:||   :||..|..|||.|  ...||...:.| .|:||..
Human    94 GLMGPRGPPGAAGAPGPQGFQGPAGEPG---EPGQTGPAGARGP--AGPPGKAGEDGHPGKPGRP 153

  Fly   283 AQPGILGQTGA----GQPGYGSQPGIGGQTG----AGQPGYGTQPGVGAQTGTGQPGYGAQPGVG 339
            .:.|::|..||    |.||.....||.|..|    .||||   .|||..:.|.  ||....||
Human   154 GERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPG---APGVKGEPGA--PGENGTPG-- 211

  Fly   340 TQTGA-GQPGYGSQPGIGGQTGA-GQPG-YGTQPGVGAQTGAGQPGYGAQPG-------VGAQTG 394
             |||| |.||...:.|..|..|| |..| .|.....|....||.||:...||       ||....
Human   212 -QTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGP 275

  Fly   395 AGQPGYGSQPGIGGQTG-AGQPGYGSQPGIGGQTGARQPGYGSQPGVGAQTGA-GQPGYGAQPG- 456
            ||..|...:.|:.|.:| .|.||   .||..|.|||:  |....|||   .|| |.||....||
Human   276 AGPAGPRGEVGLPGLSGPVGPPG---NPGANGLTGAK--GAAGLPGV---AGAPGLPGPRGIPGP 332

  Fly   457 VGAQTGAGQPGYGSQPGIGGQTGAGQPGYGSQPG-VGAQTGAGQPGYGAQPGVGAQTG-AGQPGY 519
            |||....|..|...:||..|  ..|:.|...:|| .|.|...|..|...:.|...:.| ||.||
Human   333 VGAAGATGARGLVGEPGPAG--SKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPG- 394

  Fly   520 GSQPGIGGQTGA-GQPGYGTQPGVGAQTGTGQPGYGAQPGVGTQTGAGQPGYGSQPGIGGQTG-A 582
              .||:.|..|: |.||...:.||     .|.||         ..||..|.     |:.|..| |
Human   395 --PPGLRGSPGSRGLPGADGRAGV-----MGPPG---------SRGASGPA-----GVRGPNGDA 438

  Fly   583 GQPGYGTQPGVGAQTG-TGQPGYGAQPGVGTQTGAGQPGYGSQPGYGTQPG-VGAQTGTGQPGYG 645
            |:||   :||:....| .|.||     .:|.   ||:.|....||...:|| :|.....|:||..
Human   439 GRPG---EPGLMGPRGLPGSPG-----NIGP---AGKEGPVGLPGIDGRPGPIGPAGARGEPGNI 492

  Fly   646 AQPGVGGQTGAGQPGYGTQPGIGGQTG-AGQPGYGSQPGIGGQTGG-GQPGYGSQIGGQTGAGQP 708
            ..||..|.||        .||..|..| ||..|....||..|..|. |.||
Human   493 GFPGPKGPTG--------DPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPG-------------- 535

  Fly   709 SYGSQPGVGAQNGAGQPGYGTQPVIGGQTGA-------------GQPGYGGQTGVGGSPGFLTQP 760
            ..|.|.|.|.|...|.||:...|...|..|.             |.||..|..|..|.||   :.
Human   536 PQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPG---ES 597

  Fly   761 GIGGISGPIG--GKLG--GGQSEAAKPGYWAQPGIGGPSRYGSQPGIGDQTG-TGQSGYGGQPGI 820
            |..|.:||||  |..|  |......:||.....|..|||.....||.....| .|..|..|:||:
Human   598 GAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGL 662

  Fly   821 SGQTGGGQPGYGGQATISGLPGYGTQPGIGALTAVPGGHYGYETQPGIGGQTGTNQPGFGGQPGI 885
            .|:.  |.||..|   ..|.||....||       |.|..|...:.|..|..|...|  .|.||.
Human   663 RGEI--GNPGRDG---ARGAPGAVGAPG-------PAGATGDRGEAGAAGPAGPAGP--RGSPGE 713

  Fly   886 GGQTGAGQPGYGFIGQPGIGGQTGTSGRQPGYGT--QPGIGGQT----AAGQPGYGSQTGVGGQI 944
            .|:.|...|. ||.|..|..||.|..|.:...|.  :.|:.|.|    |||..|.....|..|..
Human   714 RGEVGPAGPN-GFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSR 777

  Fly   945 G-AGQPGYGSQPGIGGQTGAGQPGYGAQPGFGGQPGYGNQPGVGGQTGAGQPGYGSQPGIG--GQ 1006
            | .|.||....||..|:||...|.     |..|.||   .||..|:.|...| .|.|..:|  |:
Human   778 GDGGPPGMTGFPGAAGRTGPPGPS-----GISGPPG---PPGPAGKEGLRGP-RGDQGPVGRTGE 833

  Fly  1007 TGA-GQPGYGAQPGFGGQLGYGNQPGVGGQTG-AGQPGYGSQPGVGGQTG-------AGQPGYGV 1062
            .|| |.||:..:.|..|:.|....||..|..| .|.||....||..|:.|       .|:||
Human   834 VGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPG--- 895

  Fly  1063 IP-GFGGQPGIGGQTAAGKPGYGGQPGIGGSPVYGTQQGTGGQSGISG--GQPGYGTQPGQTGAG 1124
             | |..|.||     |.|.||..|.||:.|:|      |..|:.|..|  |.||...|||.  .|
Human   896 -PLGIAGPPG-----ARGPPGAVGSPGVNGAP------GEAGRDGNPGNDGPPGRDGQPGH--KG 946

  Fly  1125 QPGYGSLPGT-GGQATAGQPG----YGPGSQPGIGGQTVGGHGGYGSQPGIGGAPVYGTQPGGGG 1184
            :.||   ||. |....||.||    .||..:.|..|:|       |....:|.|...|.: |..|
Human   947 ERGY---PGNIGPVGAAGAPGPHGPVGPAGKHGNRGET-------GPSGPVGPAGAVGPR-GPSG 1000

  Fly  1185 QTGVIG--GQPGQIGDRVGQPGYGTQTGQIGAPG-RYTDGSQTVPGAVGTGGVVA-AGTSG--AD 1243
            ..|:.|  |:||:.|.| |.||.....|..|.|| ....|.|..||:||..|... ||.||  ..
Human  1001 PQGIRGDKGEPGEKGPR-GLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGK 1064

  Fly  1244 DAFSQAESSIGDG--------QASASAQGKKNGGTAKTQVSGTYSSGGTFSASAMTSDADRAASA 1300
            |..:....::|..        |..|...|.. |......|||   .|..|........||:..||
Human  1065 DGRTGHPGTVGPAGIRGPQGHQGPAGPPGPP-GPPGPPGVSG---GGYDFGYDGDFYRADQPRSA 1125

  Fly  1301 QVTGNADGAVSQSQGSGGPAQSQAQVQVAKDGGTKASSQSGGIIQQSQSEVHAN------DKGGL 1359
            ......|..|..:..|   ..:|.:..:..:|..|..:::...::.|..|..:.      ::|..
Human  1126 PSLRPKDYEVDATLKS---LNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCT 1187

  Fly  1360 ADA----QSSGPGQTSSQAQ-------IGFRPGQEANPI----AANGGGQAS-SSSGTHSSQSSS 1408
            .||    .....|:|..:||       ..:|..::...:    ..|.|.|.. :..|..|.:.::
Human  1188 MDAIKVYCDFSTGETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMAT 1252

  Fly  1409 Q------IHGTSSFGVSYHGAAQSASGTKEQVATYREANRELFNTISQFGNNANAVTDRADAVYS 1467
            |      :...:|..::||        .|..:|...|....|...:...|:|...:....::.::
Human  1253 QLAFMRLLANYASQNITYH--------CKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFT 1309

  Fly  1468 GPALTDESDRVPEAQLKSTKPKEEAEQVVS-KLDHPEPVQYDDEDEADPDEYDEDEYYEEKPV 1529
            ...|.|..         |.|..|..:.::. |.:.|..:.:.|....|....|::.:.:..||
Human  1310 YTVLVDGC---------SKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPV 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prc	NP_524658.2	Pericardin_rpt	159..191	CDD:284468	10/28 (36%)
		Pericardin_rpt	176..208	CDD:284468	13/32 (41%)
		Loricrin	216..534	CDD:292475	126/350 (36%)
		Pericardin_rpt	227..259	CDD:284468	13/32 (41%)
		Pericardin_rpt	244..276	CDD:284468	12/32 (38%)
		Pericardin_rpt	295..326	CDD:284468	13/34 (38%)
		Pericardin_rpt	312..344	CDD:284468	13/31 (42%)
		Pericardin_rpt	346..378	CDD:284468	10/33 (30%)
		Pericardin_rpt	363..395	CDD:284468	11/39 (28%)
		Pericardin_rpt	397..429	CDD:284468	11/32 (34%)
		Pericardin_rpt	431..463	CDD:284468	14/33 (42%)
		Pericardin_rpt	465..497	CDD:284468	10/32 (31%)
		Pericardin_rpt	482..514	CDD:284468	9/33 (27%)
		Pericardin_rpt	516..547	CDD:284468	11/31 (35%)
		Pericardin_rpt	533..565	CDD:284468	7/31 (23%)
		Pericardin_rpt	567..598	CDD:284468	10/31 (32%)
		Pericardin_rpt	584..616	CDD:284468	9/32 (28%)
		Pericardin_rpt	624..656	CDD:284468	12/32 (38%)
		Pericardin_rpt	641..673	CDD:284468	11/32 (34%)
		Pericardin_rpt	841..873	CDD:284468	9/31 (29%)
		Pericardin_rpt	893..929	CDD:284468	13/41 (32%)
		Glutenin_hmw	925..>1382	CDD:281191	154/511 (30%)
		Pericardin_rpt	948..992	CDD:284468	15/43 (35%)
		Pericardin_rpt	977..1009	CDD:284468	11/33 (33%)
COL1A2	NP_000080.2	Collagen	115..174	CDD:189968	24/63 (38%)
		Collagen	148..207	CDD:189968	24/63 (38%)
		Collagen	187..246	CDD:189968	26/66 (39%)
		Collagen	268..327	CDD:189968	26/66 (39%)
		Collagen	436..497	CDD:189968	24/71 (34%)
		Collagen	469..528	CDD:189968	23/66 (35%)
		Collagen	580..649	CDD:189968	25/71 (35%)
		Collagen	919..973	CDD:189968	24/64 (38%)
		Collagen	955..1013	CDD:189968	20/65 (31%)
		COLFI	1134..1365	CDD:279718	42/250 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000