DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chm and SAMD1

DIOPT Version :9

Sequence 1:	NP_001260192.1	Gene:	chm / 43928	FlyBaseID:	FBgn0028387	Length:	811	Species:	Drosophila melanogaster
Sequence 2:	NP_612361.1	Gene:	SAMD1 / 90378	HGNCID:	17958	Length:	538	Species:	Homo sapiens

Alignment Length:	435	Identity:	85/435 - (19%)
Similarity:	136/435 - (31%)	Gaps:	134/435 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 STSGSTSSETGSSSDTDSSSATPEEKPSTNSSAKSQTQTQQQTNSGNAQRRKPVPAASEDKPKPS 80
            |..||.|....:........|||...|                   .|.|..|..||:. .|.|:
Human    86 SYKGSISYRNAARVQPPRRGATPPAPP-------------------RAPRGAPAAAAAA-APPPT 130

  Fly    81 VAPSSKKVNNPPKSKLSSDDDEYEDSAP------------------PAKKNSRAMGSSTVTAAAA 127
            .||.      ||.:.:::       :||                  ||:...||..::.:.|...
Human   131 PAPP------PPPAPVAA-------AAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPP 182

  Fly   128 ASAA----------RRKPPASV---NKPSNPANKPSNPTQR---------------------SAN 158
            |.||          ||.||.:|   ..|..|..:|..|.|:                     :|.
Human   183 APAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRAGGAAR 247

  Fly   159 NNTNRSL------ENGEGKRPSLSSSSNSTDDSMKIVKNGRKVPLKMASTVRPKQIR-GKLPPA- 215
            ..:.|.:      ..|.|.|.:........::  :....||....::.:...|:..| |:.|||
Human   248 PVSLREVVRYLGGSGGAGGRLTRGRVQGLLEE--EAAARGRLERTRLGALALPRGDRPGRAPPAA 310

  Fly   216 -------KKNGGGPVISSDGSSGSESGSNSGDESSSGSESEGSDSSNSYSSQPVKGGAKGKRSGP 273
                   |:.|...|:..:.....:...:..|:.|.|||...||.........: .|.:|.:|..
Human   311 SARPSRSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVPESDRPAGAQHHQL-NGERGPQSAK 374

  Fly   274 TKIQN------SDSEEERKDKA--NPMRKLTRSLSMRRTKQQPKQET--DSESDGDLEDDKIMIS 328
            .:::.      ...::|.:..|  :..|::....:|.:........|  ||.|...|
Human   375 ERVKEWTPCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVATGPDSPSPVPL-------- 431

  Fly   329 KSPAKKPAPSNLNASKSKVKREPIGISSGVLSSIKSRPVSPITQT 373
              |..|||....:.:       |.|...|    .|.:|..|:..|
Human   432 --PPGKPALPGADGT-------PFGCPPG----RKEKPSDPVEWT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chm	NP_001260192.1	zf-C2HC	376..402	CDD:279824
		NAT_SF	526..802	CDD:302625
		MOZ_SAS	584..766	CDD:280097
SAMD1	NP_612361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..247		36/187 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..458		39/197 (20%)
		SAM_Atherin-like	459..527	CDD:188982	2/5 (40%)
		SAM	459..525	CDD:197735	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900